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Gene Information

Gene symbol: HBD

Gene name: hemoglobin, delta

HGNC ID: 4829

Related Genes

#	Gene Symbol	Number of hits
1	IL8	1 hits

Related Sentences

#	PMID	Sentence
1	20213311	Treponema denticola suppresses expression of human beta-defensin-2 in gingival epithelial cells through inhibition of TNFalpha production and TLR2 activation.
2	20213311	We previously reported that Treponema denticola, a periodontal pathogen, suppressed the expression of human beta-defensins (HBDs) and IL-8 in human gingival epithelial cells.
3	20213311	Time courses of suppression revealed that T. denticola suppressed HBD-2 expression only at late time points, which was accompanied with the suppression of TNFalpha production.
4	20213311	Neutralization of TNFalpha with an antibody abrogated the suppressive effect of T. denticola on HBD-2.
5	20213311	Knock-down of toll-like receptor (TLR) 2 via RNA interference reversed the suppressive effect of T. denticola on the expression of HBD-3, but not on the production of TNFalpha.
6	20213311	Collectively, T. denticola suppresses the expression of HBD-2 in gingival epithelial cells by inhibiting the TLR2 axis and TNFalpha production, which may contribute to the pathogenesis of periodontitis by T. denticola.