Ignet

Gene Information

Gene symbol: HHLA2

Gene name:

HGNC ID:

Related Genes

#	Gene Symbol	Number of hits
1	CD276	1 hits
2	CD28	1 hits
3	CD4	1 hits
4	CD8A	1 hits
5	IL10	1 hits
6	IL13	1 hits
7	IL17A	1 hits
8	IL17D	1 hits
9	IL5	1 hits
10	VTCN1	1 hits

Related Sentences

#	PMID	Sentence
1	23716685	HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
2	23716685	Here we describe HERV-H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and phylogenetically forms a subfamily with B7x and B7-H3 within the family.
3	23716685	HHLA2 is expressed in humans but not in mice, which is unique within the B7 and CD28 families.
4	23716685	HHLA2 does not interact with other known members of the CD28 family or the B7 family, but does bind a putative receptor that is constitutively expressed not only on resting and activated CD4 and CD8 T cells but also on antigen-presenting cells.
5	23716685	HHLA2 inhibits proliferation of both CD4 and CD8 T cells in the presence of T-cell receptor signaling.
6	23716685	In addition, HHLA2 significantly reduces cytokine production by T cells including IFN-γ, TNF-α, IL-5, IL-10, IL-13, IL-17A, and IL-22.
7	23716685	Thus, we have identified a unique B7 pathway that is able to inhibit human CD4 and CD8 T-cell proliferation and cytokine production.
8	23716685	HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
9	23716685	Here we describe HERV-H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and phylogenetically forms a subfamily with B7x and B7-H3 within the family.
10	23716685	HHLA2 is expressed in humans but not in mice, which is unique within the B7 and CD28 families.
11	23716685	HHLA2 does not interact with other known members of the CD28 family or the B7 family, but does bind a putative receptor that is constitutively expressed not only on resting and activated CD4 and CD8 T cells but also on antigen-presenting cells.
12	23716685	HHLA2 inhibits proliferation of both CD4 and CD8 T cells in the presence of T-cell receptor signaling.
13	23716685	In addition, HHLA2 significantly reduces cytokine production by T cells including IFN-γ, TNF-α, IL-5, IL-10, IL-13, IL-17A, and IL-22.
14	23716685	Thus, we have identified a unique B7 pathway that is able to inhibit human CD4 and CD8 T-cell proliferation and cytokine production.
15	23716685	HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
16	23716685	Here we describe HERV-H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and phylogenetically forms a subfamily with B7x and B7-H3 within the family.
17	23716685	HHLA2 is expressed in humans but not in mice, which is unique within the B7 and CD28 families.
18	23716685	HHLA2 does not interact with other known members of the CD28 family or the B7 family, but does bind a putative receptor that is constitutively expressed not only on resting and activated CD4 and CD8 T cells but also on antigen-presenting cells.
19	23716685	HHLA2 inhibits proliferation of both CD4 and CD8 T cells in the presence of T-cell receptor signaling.
20	23716685	In addition, HHLA2 significantly reduces cytokine production by T cells including IFN-γ, TNF-α, IL-5, IL-10, IL-13, IL-17A, and IL-22.
21	23716685	Thus, we have identified a unique B7 pathway that is able to inhibit human CD4 and CD8 T-cell proliferation and cytokine production.
22	23716685	HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
23	23716685	Here we describe HERV-H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and phylogenetically forms a subfamily with B7x and B7-H3 within the family.
24	23716685	HHLA2 is expressed in humans but not in mice, which is unique within the B7 and CD28 families.
25	23716685	HHLA2 does not interact with other known members of the CD28 family or the B7 family, but does bind a putative receptor that is constitutively expressed not only on resting and activated CD4 and CD8 T cells but also on antigen-presenting cells.
26	23716685	HHLA2 inhibits proliferation of both CD4 and CD8 T cells in the presence of T-cell receptor signaling.
27	23716685	In addition, HHLA2 significantly reduces cytokine production by T cells including IFN-γ, TNF-α, IL-5, IL-10, IL-13, IL-17A, and IL-22.
28	23716685	Thus, we have identified a unique B7 pathway that is able to inhibit human CD4 and CD8 T-cell proliferation and cytokine production.
29	23716685	HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
30	23716685	Here we describe HERV-H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and phylogenetically forms a subfamily with B7x and B7-H3 within the family.
31	23716685	HHLA2 is expressed in humans but not in mice, which is unique within the B7 and CD28 families.
32	23716685	HHLA2 does not interact with other known members of the CD28 family or the B7 family, but does bind a putative receptor that is constitutively expressed not only on resting and activated CD4 and CD8 T cells but also on antigen-presenting cells.
33	23716685	HHLA2 inhibits proliferation of both CD4 and CD8 T cells in the presence of T-cell receptor signaling.
34	23716685	In addition, HHLA2 significantly reduces cytokine production by T cells including IFN-γ, TNF-α, IL-5, IL-10, IL-13, IL-17A, and IL-22.
35	23716685	Thus, we have identified a unique B7 pathway that is able to inhibit human CD4 and CD8 T-cell proliferation and cytokine production.
36	23716685	HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
37	23716685	Here we describe HERV-H LTR-associating protein 2 (HHLA2) as a member of the B7 family that shares 10-18% amino acid identity and 23-33% similarity to other human B7 proteins and phylogenetically forms a subfamily with B7x and B7-H3 within the family.
38	23716685	HHLA2 is expressed in humans but not in mice, which is unique within the B7 and CD28 families.
39	23716685	HHLA2 does not interact with other known members of the CD28 family or the B7 family, but does bind a putative receptor that is constitutively expressed not only on resting and activated CD4 and CD8 T cells but also on antigen-presenting cells.
40	23716685	HHLA2 inhibits proliferation of both CD4 and CD8 T cells in the presence of T-cell receptor signaling.
41	23716685	In addition, HHLA2 significantly reduces cytokine production by T cells including IFN-γ, TNF-α, IL-5, IL-10, IL-13, IL-17A, and IL-22.
42	23716685	Thus, we have identified a unique B7 pathway that is able to inhibit human CD4 and CD8 T-cell proliferation and cytokine production.