Ignet

Gene Information

Gene symbol: HPD

Gene name: 4-hydroxyphenylpyruvate dioxygenase

HGNC ID: 5147

Synonyms: 4-HPPD, 4HPPD, GLOD3

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	CD4	1 hits
3	CD69	1 hits
4	CD79A	1 hits
5	CD8A	1 hits
6	CFP	1 hits
7	IFNG	1 hits
8	IL2	1 hits
9	IL4	1 hits
10	LBR	1 hits
11	LIF	1 hits
12	MERTK	1 hits
13	MLC1	1 hits
14	TBC1D1	1 hits
15	TBP	1 hits
16	TST	1 hits
17	VWS	1 hits

Related Sentences

#	PMID	Sentence
1	133010	B-cell deficiencies such as hypogammaglobulinaemia, have normal PPD and PHA induced LIF production, whilst some patients with ataxia-telangiectasia have defective PPD LIF activity, their PHA LIF activity being only minimally depressed.
2	137880	After 6 months of treatment, all lymphocyte samples from an individual were recovered and tested for DNA synthesis after stimulation with PHA, PWM, Con A, PPD and MLC.
3	137880	Of the assays employed, the MLC and PPD tests appear to be the most useful as monitors of clinical status and response to therapy.
4	137880	After 6 months of treatment, all lymphocyte samples from an individual were recovered and tested for DNA synthesis after stimulation with PHA, PWM, Con A, PPD and MLC.
5	137880	Of the assays employed, the MLC and PPD tests appear to be the most useful as monitors of clinical status and response to therapy.
6	553113	However, there was a decreased responsiveness to PHA and PPD with continuing treatment with MER-BCG.
7	770312	Both MER and PPD enhanced the in vitro immune response of Balb/C mice to SRBC and to TNP (trinitrophenyl) hapten.
8	770312	MER, LPS and PPD enhanced the immune response of nude spleen cells to SRBC in vitro.
9	770312	Both MER and PPD enhanced the in vitro immune response of Balb/C mice to SRBC and to TNP (trinitrophenyl) hapten.
10	770312	MER, LPS and PPD enhanced the immune response of nude spleen cells to SRBC in vitro.
11	1069547	The pretreatment immunoresponsiveness of these 98 patients was suppressed, as measured by the following immunologic parameters: T-cell subpopulation in the peripheral blood, stimulation index of PHA, and skin tests to DNCB, KLH, PPD, and PHA.
12	5523576	The effect of PHA, PPD, allogeneic cells, and sheep erythrocytes on albumin gradient-fractionated mouse spleen cell populations.
13	6489488	Activation of lymphocytes by PPD and PHA is promoted by exudate from BCG-induced pleurisy.
14	6489488	Cell-free pleural exudate (PE) obtained from guinea pigs with BCG-induced pleurisy was tested for influence on in vitro activation of lymphocytes by PHA and PPD.
15	6489488	Thus, in the presence of PE, lymphocytes derived from the pleural exudate were always activated in vitro by PHA and PPD.
16	6489488	Activation of lymphocytes by PPD and PHA is promoted by exudate from BCG-induced pleurisy.
17	6489488	Cell-free pleural exudate (PE) obtained from guinea pigs with BCG-induced pleurisy was tested for influence on in vitro activation of lymphocytes by PHA and PPD.
18	6489488	Thus, in the presence of PE, lymphocytes derived from the pleural exudate were always activated in vitro by PHA and PPD.
19	6489488	Activation of lymphocytes by PPD and PHA is promoted by exudate from BCG-induced pleurisy.
20	6489488	Cell-free pleural exudate (PE) obtained from guinea pigs with BCG-induced pleurisy was tested for influence on in vitro activation of lymphocytes by PHA and PPD.
21	6489488	Thus, in the presence of PE, lymphocytes derived from the pleural exudate were always activated in vitro by PHA and PPD.
22	6880746	The addition of PPD or PHA lymphokines to the peritoneal cells from BCG injected mice depressed the chemotactic response, but increased unstimulated migration.
23	6969625	Among the immune parameters, only in vitro blastogenic responses to PHA and PPD rose significantly in the BCG group compared with the controls.
24	7140874	Low in vitro response to PPD and PHA in lymphocytes from BCG-induced pleurisy in guinea pigs.
25	7140874	Pleural lymphocytes sampled on the third post-induction day did not respond to PPD or PHA stimulation.
26	7140874	Low in vitro response to PPD and PHA in lymphocytes from BCG-induced pleurisy in guinea pigs.
27	7140874	Pleural lymphocytes sampled on the third post-induction day did not respond to PPD or PHA stimulation.
28	7142369	The majority of PPD-induced IgA synthesis was by cells lacking surface membrane IgD, similar to PPD-reactive IgG secretors.
29	7346040	Immunological examinations before vaccination showed that the numbers of white blood cells, percentages of lymphocytes, levels of immunoglobulins and responses to skin tests with DNCB, PPD, PHA and varicella antigen were within normal ranges in most of these children.
30	9129985	Only those cocultures with non-adherent cells from TBP PPD+ patients treated with anergic sera, inhibited the LT response induced by PPD, whereas sera adsorption with BCG eliminated the inhibitory effect.
31	12191514	We have assessed the optimal conditions in terms of dose and kinetics of those cytokines which are released early (TNF-alpha, IL6 and TGF-beta, IL10) or (interferon [IFN]-gamma and IL5) in WB cultures stimulated with mitogens and mycobacterial antigens.
32	12191514	Using unpaired Student's t-tests, pulmonary tuberculosis patients (P.TB; n=11), in response to CFP, showed higher monocyte-derived IL6 (p=0.023) and IL10 (p=0.042) compared to endemic controls (EC; n=13), and significantly suppressed T-cell-derived IFN-gamma (p=0.028) and IL5 (p=0.012) secretion but increased IL10 (p=0.047) on day 5, indicating that CFP is a strong stimulus for IL10 secretion in pulmonary TB patients.
33	12191514	Extrapulmonary TB patients (E.TB; n=6) showed no elevation of early monocyte-derived cytokines to either PPD or CFP, but showed a marked suppression of the T-cell-derived cytokines IFN-gamma (PPD, p=0.015; CFP, p=0.05) and IL5 (PPD, p=0.05; CFP, p=0.015).
34	17049309	The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD.
35	17049309	PPD-stimulated peripheral leukocytes expressing CD4, CD69, cutaneous lymphocyte-associated antigen (CLA) and intracellular IFN-gamma were enumerated in whole blood and compared with the size of in vivo PPD-induced induration and IFN-gamma production levels as measured by ELISA in supernatants of PPD-stimulated peripheral blood mononuclear cells.
36	17049309	The reactivity to the tuberculin skin test (TST) was associated with markedly increased frequencies of PPD-responsive activated (CD69+) and IFN-gamma-producing CD4+T cells.
37	17049309	Detection of PPD-specific IFN-gamma producing leukocytes was restricted to CD4+T cells and a subset of these cells was shown to express the skin homing molecule CLA.
38	17049309	Multiple linear regression modeling of responses to PPD showed the highest association between skin test indurations and frequencies of PPD-responsive IFN-gamma-producing CD4+CD69+ T cells.
39	17049309	The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD.
40	17049309	PPD-stimulated peripheral leukocytes expressing CD4, CD69, cutaneous lymphocyte-associated antigen (CLA) and intracellular IFN-gamma were enumerated in whole blood and compared with the size of in vivo PPD-induced induration and IFN-gamma production levels as measured by ELISA in supernatants of PPD-stimulated peripheral blood mononuclear cells.
41	17049309	The reactivity to the tuberculin skin test (TST) was associated with markedly increased frequencies of PPD-responsive activated (CD69+) and IFN-gamma-producing CD4+T cells.
42	17049309	Detection of PPD-specific IFN-gamma producing leukocytes was restricted to CD4+T cells and a subset of these cells was shown to express the skin homing molecule CLA.
43	17049309	Multiple linear regression modeling of responses to PPD showed the highest association between skin test indurations and frequencies of PPD-responsive IFN-gamma-producing CD4+CD69+ T cells.
44	17049309	The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD.
45	17049309	PPD-stimulated peripheral leukocytes expressing CD4, CD69, cutaneous lymphocyte-associated antigen (CLA) and intracellular IFN-gamma were enumerated in whole blood and compared with the size of in vivo PPD-induced induration and IFN-gamma production levels as measured by ELISA in supernatants of PPD-stimulated peripheral blood mononuclear cells.
46	17049309	The reactivity to the tuberculin skin test (TST) was associated with markedly increased frequencies of PPD-responsive activated (CD69+) and IFN-gamma-producing CD4+T cells.
47	17049309	Detection of PPD-specific IFN-gamma producing leukocytes was restricted to CD4+T cells and a subset of these cells was shown to express the skin homing molecule CLA.
48	17049309	Multiple linear regression modeling of responses to PPD showed the highest association between skin test indurations and frequencies of PPD-responsive IFN-gamma-producing CD4+CD69+ T cells.
49	17049309	The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD.
50	17049309	PPD-stimulated peripheral leukocytes expressing CD4, CD69, cutaneous lymphocyte-associated antigen (CLA) and intracellular IFN-gamma were enumerated in whole blood and compared with the size of in vivo PPD-induced induration and IFN-gamma production levels as measured by ELISA in supernatants of PPD-stimulated peripheral blood mononuclear cells.
51	17049309	The reactivity to the tuberculin skin test (TST) was associated with markedly increased frequencies of PPD-responsive activated (CD69+) and IFN-gamma-producing CD4+T cells.
52	17049309	Detection of PPD-specific IFN-gamma producing leukocytes was restricted to CD4+T cells and a subset of these cells was shown to express the skin homing molecule CLA.
53	17049309	Multiple linear regression modeling of responses to PPD showed the highest association between skin test indurations and frequencies of PPD-responsive IFN-gamma-producing CD4+CD69+ T cells.
54	17049309	The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD.
55	17049309	PPD-stimulated peripheral leukocytes expressing CD4, CD69, cutaneous lymphocyte-associated antigen (CLA) and intracellular IFN-gamma were enumerated in whole blood and compared with the size of in vivo PPD-induced induration and IFN-gamma production levels as measured by ELISA in supernatants of PPD-stimulated peripheral blood mononuclear cells.
56	17049309	The reactivity to the tuberculin skin test (TST) was associated with markedly increased frequencies of PPD-responsive activated (CD69+) and IFN-gamma-producing CD4+T cells.
57	17049309	Detection of PPD-specific IFN-gamma producing leukocytes was restricted to CD4+T cells and a subset of these cells was shown to express the skin homing molecule CLA.
58	17049309	Multiple linear regression modeling of responses to PPD showed the highest association between skin test indurations and frequencies of PPD-responsive IFN-gamma-producing CD4+CD69+ T cells.
59	18023944	The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo.
60	18023944	TST alone significantly induced PPD-specific IFN-gamma producing cells.
61	18023944	The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo.
62	18023944	TST alone significantly induced PPD-specific IFN-gamma producing cells.
63	18692540	We were also able to detect PPD-specific IFN-gamma release during short term culture of blood from a number of humans with active TB indicating that this test may have wider application and is potentially useful for the rapid diagnosis of disease in humans.
64	20805423	TCR repertoire, clonal dominance, and pulmonary trafficking of mycobacterium-specific CD4+ and CD8+ T effector cells in immunity against tuberculosis.
65	20805423	Clonal responses of Mycobacterium tuberculosis-specific CD4(+) or CD8(+) T effector cells producing antituberculosis cytokine IFN-γ in the context of immune protection against tuberculosis remain poorly characterized in humans.
66	20805423	We found that while PPD-specific CD4(+) and CD8(+) T effector clones employed diverse TCR Vβ repertoires, 30-33% of IFN-γ(+)CD4(+) T cell clones from three M. tuberculosis-infected macaques expressed TCR bearing a conserved residue leucine in CDR3.
67	20805423	Many Ag-specific IFN-γ(+) CD4(+) and few CD8(+) T effector cells emerged as dominant clones during mycobacterial infections and underwent major recall expansion after pulmonary M. tuberculosis infection of BCG-vaccinated macaques.
68	22342709	BCG vaccination did not significantly modulate the levels of serum IFN-γ and the frequency of splenic PPD-reactive IFN-γ-secreting T cells, but significantly decreased the levels of serum TNF-α and PPD-specific IL-4 responses at 3 weeks post challenge.
69	24039703	Interferon (IFN)-γ and interleukin (IL)-2 producing PPD-specific CD4 T cells were analysed longitudinally before each instillation using a rapid flow-cytometric whole blood immunoassay.
70	24471299	Other mandatory examinations include chest radiography, PPD and TBC serology using interferon gamma release test (IGRA).
71	24992314	The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy indian adolescents.