Ignet

Gene Information

Gene symbol: HSPA5

Gene name: heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

HGNC ID: 5238

Synonyms: BiP

Related Genes

#	Gene Symbol	Number of hits
1	ANXA6	1 hits
2	ATF4	1 hits
3	ATF6	1 hits
4	BAX	1 hits
5	BCL2	1 hits
6	CALR	1 hits
7	CANX	1 hits
8	CASP3	1 hits
9	CD8A	1 hits
10	CYCS	1 hits
11	DDIT3	1 hits
12	DNAJB9	1 hits
13	EIF2AK3	1 hits
14	EIF2S1	1 hits
15	GLI2	1 hits
16	GRP	1 hits
17	GTF2A1	1 hits
18	HLA-A	1 hits
19	HSP90B1	1 hits
20	HSPA1A	1 hits
21	HYOU1	1 hits
22	IL24	1 hits
23	MCL1	1 hits
24	PDIA2	1 hits
25	PPP1R15A	1 hits
26	TUBA1B	1 hits
27	XBP1	1 hits

Related Sentences

#	PMID	Sentence
1	10725457	So far, four classes of heat shock proteins (HSPs) preparation: gp96, HSP90 (hsp86, hsp84), HSP70 (hsc70, hsp70) and calreticulin have been used successfully.
2	10725457	We report here that hsp40, hsp60, hsc70, hsp70, hsp84, hsp86, and gp96 (grp94) but not BiP (grp78) and calreticulin can be separated from a single tumor sample in one step using heparin-agarose chromatography.
3	11566370	Glucose Regulated Protein (GRP78), a member of the 70 kDa heat-shock protein family was identified and characterised.
4	11602760	Unfolded or partially folded E1 bound to the endoplasmic reticulum chaperones calnexin and (with lower efficiency) calreticulin, whereas no binding to BiP/GRP78 or GRP94 could be detected.
5	11602760	Release from calnexin and calreticulin was used to assess formation of mature E1.
6	12000658	The recently cloned glucose regulated protein 78 (GRP78) of Leishmania donovani has been suggested as a new and promising Leishmania vaccine candidate.
7	20219895	Pull-down and MALDI-TOF MS experiments identified three host-cell proteins, Grp 78/Bip, alpha-tubulin and heat-shock protein 90 (HSP90), and the latter was investigated further.
8	20628775	By comparing with the known structure of the Hsp70:J complex, we further concluded that the interaction of Grp78 and E2s could interrupt binding of Grp78 with the J domain, and in turn diminish or even eliminate the binding ability of the Grp78 substrate binding domain.
9	20957756	Thus, a well-characterized HER-2/neu oncogene-driven mammary carcinogenesis model was analysed by various profiling strategies following "triplex" vaccination to identify new candidate targets for breast cancer immunoprevention. 2-DE-based proteomic profiling of preneoplastic and tumour lesions versus normal and aged mammary tissue demonstrated that tumour progression was associated with an up-regulation of molecular chaperones including glucose-regulated protein (GRP)78 and of proteins favouring cell motility, which was in line with the corresponding transcriptomic profiling data.
10	20957756	The distinct expression patterns for annexin A6 and GRP78 during tumour progression were further verified by western blot and/or immunoprecipitation.
11	21339366	However, contrary to other ER-resident heat shock proteins such as gp96, calreticulin, and ORP150, it is not clear whether tumor-derived BiP plays a role in inducing antitumor immunity.
12	21339366	In this study, we show that the tumor-derived secreted form of BiP is capable of inducing antitumor CD8(+) T cell responses.
13	21339366	We show that this secreted BiP is taken up by bone marrow-derived dendritic cells, and thereafter BiP-associated Ag peptide is cross-presented in association with MHC class I molecules, resulting in elicitation of an Ag-specific CD8(+) T cell response and antitumor effect.
14	21339366	However, contrary to other ER-resident heat shock proteins such as gp96, calreticulin, and ORP150, it is not clear whether tumor-derived BiP plays a role in inducing antitumor immunity.
15	21339366	In this study, we show that the tumor-derived secreted form of BiP is capable of inducing antitumor CD8(+) T cell responses.
16	21339366	We show that this secreted BiP is taken up by bone marrow-derived dendritic cells, and thereafter BiP-associated Ag peptide is cross-presented in association with MHC class I molecules, resulting in elicitation of an Ag-specific CD8(+) T cell response and antitumor effect.
17	21339366	However, contrary to other ER-resident heat shock proteins such as gp96, calreticulin, and ORP150, it is not clear whether tumor-derived BiP plays a role in inducing antitumor immunity.
18	21339366	In this study, we show that the tumor-derived secreted form of BiP is capable of inducing antitumor CD8(+) T cell responses.
19	21339366	We show that this secreted BiP is taken up by bone marrow-derived dendritic cells, and thereafter BiP-associated Ag peptide is cross-presented in association with MHC class I molecules, resulting in elicitation of an Ag-specific CD8(+) T cell response and antitumor effect.
20	25614217	Quantitative gene expression analysis of PDI, BiP, bZIP60, SKP1, 26Sα proteasome and PR1a, and the detection of ubiquitinated CTB polypeptides revealed that N-glycosylation significantly relieved ER stress and hypersensitive response, and facilitated the folding/assembly of CTB.
21	25633898	Finally, we discovered the over-expression of GRP78, ATF4, ATF6, PERK, eIF2α, CHOP, and cytochrome c (Cyt-c) but not IRE1, xbp-1, and caspase-3 in B.suis.S2 (HK)-attacked and B.suis.S2-infected cells, suggesting that the molecular mechanism of ER stress sensor activation by B.suis.S2 is basically concomitant with that by B.suis.S2 (HK) and that ER stress, especially the PERK pathway, plays an important role in the process of B.suis.S2 infecting EEC, which may, in part, explain the role of the uterus in the pathogenesis of B.suis.S2.
22	26225923	Interleukin-24 (IL-24), a member of the IL-10 cytokine gene family, causes growth suppression and apoptosis in various solid tumor cells.
23	26225923	In addition, IL-24 expression could significantly induce apoptosis of the THP-1 cells.
24	26225923	Ad.RGD-IL-24 had a potent effect on the up-regulation of the expression of GRP78/Bip, GADD34 and Bax, down-regulation of the expression of Bcl-2 and Mcl-1, and induced the activation of Caspase-3, which may be responsible for its apoptosis-inducing effect on THP-1 cells.
25	24339776	In this study, B. melitensis infection up regulated expression of the UPR target genes BiP, CHOP, and ERdj4, and induced XBP1 mRNA splicing in murine macrophages.
26	24339776	However, up regulation of CHOP, and ERdj4 was completely MyD88 independent.
27	24339776	Heat killed Brucella stimulated significantly less BiP, CHOP, and ERdj4 expression, but induced XBP1 splicing.
28	24339776	Although a Brucella VirB mutant showed relatively intact UPR induction, a TcpB mutant had significantly compromised BiP, CHOP and ERdj4 expression.
29	24339776	In this study, B. melitensis infection up regulated expression of the UPR target genes BiP, CHOP, and ERdj4, and induced XBP1 mRNA splicing in murine macrophages.
30	24339776	However, up regulation of CHOP, and ERdj4 was completely MyD88 independent.
31	24339776	Heat killed Brucella stimulated significantly less BiP, CHOP, and ERdj4 expression, but induced XBP1 splicing.
32	24339776	Although a Brucella VirB mutant showed relatively intact UPR induction, a TcpB mutant had significantly compromised BiP, CHOP and ERdj4 expression.
33	24339776	In this study, B. melitensis infection up regulated expression of the UPR target genes BiP, CHOP, and ERdj4, and induced XBP1 mRNA splicing in murine macrophages.
34	24339776	However, up regulation of CHOP, and ERdj4 was completely MyD88 independent.
35	24339776	Heat killed Brucella stimulated significantly less BiP, CHOP, and ERdj4 expression, but induced XBP1 splicing.
36	24339776	Although a Brucella VirB mutant showed relatively intact UPR induction, a TcpB mutant had significantly compromised BiP, CHOP and ERdj4 expression.