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Gene Information
Gene symbol: IFNR
Gene name: interferon production regulator
HGNC ID: 5447
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNAR2 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL10 | 1 hits |
| 4 | IL12A | 1 hits |
| 5 | IL12RB2 | 1 hits |
| 6 | IL15 | 1 hits |
| 7 | IL6 | 1 hits |
| 8 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16704888 | The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. |
| 2 | 16704888 | Poly (I:C), a TLR3 ligand, has shown promise as a vaccine adjuvant to CD8(+) T cell responses. |
| 3 | 16704888 | Poly (I:C) treatment was associated with a rapid induction of inflammatory cytokines in the serum, including IL-6, IL-10, MCP-1, TNF-alpha, IFN-alpha, and IFN-gamma, and selective increases in the numbers of NK (NK1.1(+)CD11b(+)) cells and Mvarphi (NK1.1(-)CD11b(+)), but not NK T (CD3(+)NK1.1(+)) cells. |
| 4 | 16704888 | Poly (I:C) treatment in TNF-alpha, type I IFNR, IFN-gamma, IL-6, IL-12Rbeta2, or IL-15 gene-deficient mice revealed a reciprocal interaction and interdependence in the induction of these cytokines, where the absence of one cytokine impacted on the production of others. |
| 5 | 16704888 | Further, the adjuvant effects of poly (I:C) were dependent on the endogenous levels of type I IFNs, TNF-alpha, IFN-gamma, IL-12, and IL-15. |
| 6 | 16704888 | IFN-alpha and IFN-beta, but not TNF-alpha or IL-6, were able to mimic the adjuvant effects of poly (I:C). |
| 7 | 23508902 | Peripheral blood lymphocyte counts indicated lymphopenia and inverted ratios of CD4(+) to CD8(+) cells. |
| 8 | 23508902 | Cytokine analysis showed that the levels of serum IL-6, IL-10, and IFN-r continued to increase, whereas the levels of IL-12 and TNFs decreased during the clinical course. |
| 9 | 23508902 | MCP-1 and IP-10 remained at a high level after infection. |
| 10 | 25043151 | The high levels of IFN-r and IL-10 showed the VP1 protein induced a mixed Th1 and Th2 immune response. |