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Gene Information
Gene symbol: IKBKB
Gene name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
HGNC ID: 5960
Synonyms: IKK2, NFKBIKB, IKK-beta, IKKB
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNG | 1 hits |
| 2 | IKBKG | 1 hits |
| 3 | IL10 | 1 hits |
| 4 | JAK1 | 1 hits |
| 5 | NFKB1 | 1 hits |
| 6 | TBK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14963119 | Mice treated intranasally with interleukin-10 or with a specific cell-permeable peptide that blocks the association of the catalytic subunit IKKbeta with the regulatory protein NEMO showed a striking reduction of lung NF-kappaB DNA binding activity, chemokine gene expression, and airway inflammation in response to RSV infection. |
| 2 | 20444990 | Vaccinia virus (VACV) encodes multiple proteins to evade host innate immunity, including B14, a virulence factor that binds to the inhibitor of kappaB kinase beta (IKKbeta) and blocks nuclear factor kappaB (NF-kappaB) activation. |
| 3 | 25390891 | We report that IFN inhibitors targeting components of the IFN response (TBK1, IKK2, JAK1) significantly increased virus replication. |
| 4 | 25390891 | More specifically, the JAK1/2 inhibitor Ruxolitinib enhances the growth of viruses that are sensitive to IFN due to (i) loss of function of the viral IFN antagonist (due to mutation or species-specific constraints) or (ii) mutations/host cell constraints that slow virus spread such that it can be controlled by the IFN response. |