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Gene Information
Gene symbol: IKBKE
Gene name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
HGNC ID: 14552
Synonyms: IKKE, IKK-i, KIAA0151
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EGR1 | 1 hits |
| 2 | IL2 | 1 hits |
| 3 | IL6 | 1 hits |
| 4 | IRAK2 | 1 hits |
| 5 | MAPK8 | 1 hits |
| 6 | MYC | 1 hits |
| 7 | NFKB1 | 1 hits |
| 8 | NFKBIA | 1 hits |
| 9 | PRKDC | 1 hits |
| 10 | TICAM1 | 1 hits |
| 11 | TLR2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21424379 | The major alleles of coding SNPs in the TLR2 (rs3804100) and TLR4 (rs5030710) genes were associated with a dose-related increase (660 vs. 892 mIU/ml, p = 0.002) and a dose-related decrease (2,209 vs. 830 mIU/ml, p = 0.001) in measles-specific antibodies, respectively. |
| 2 | 21424379 | We observed an additional 12 associations (p < 0.01) between coding (nonsynonymous and synonymous) polymorphisms within the TLRs (TLR2, 7, and 8), IKBKE, TICAM1, NFKBIA, IRAK2, and KIAA1542 genes and variations in measles-specific IL-2, IL-6, IFN-α, IFN-γ, IFNλ-1, and TNF-α secretion levels. |
| 3 | 23533581 | Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells. |
| 4 | 23533581 | CpG-ODN activates the TLR9/MyD88/TRAF6 cascade leading to activation of IKK-NF-κB and JNK, which are critical for production of pro-inflammatory cytokines. |
| 5 | 23533581 | DNA-PKcs-deficient DCs exhibited a defect in the IL-6 and IL-12 response to CpG-ODN in a dose- and time-dependent manner. |
| 6 | 23533581 | Loss of DNA-PKcs impaired phosphorylation of IKK, IκBα, NF-κB and JNK in response to CpG-ODN. |
| 7 | 25324841 | The 24-h network featured a small number of key hub and bottleneck gene nodes, including IKBKE, MYC, NFKB1, and EGR1 that differentiated the macrophage response to virulent and attenuated M. bovis strains, possibly via the modulation of host cell death mechanisms. |