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Gene Information
Gene symbol: IKBKG
Gene name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
HGNC ID: 5961
Synonyms: IKK-gamma, NEMO, Fip3p, FIP-3, FIP3, ZC2HC9
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CYBB | 1 hits |
| 2 | IFNGR1 | 1 hits |
| 3 | IFNGR2 | 1 hits |
| 4 | IKBKB | 1 hits |
| 5 | IL10 | 1 hits |
| 6 | IL12B | 1 hits |
| 7 | IL12RB1 | 1 hits |
| 8 | IRAK4 | 1 hits |
| 9 | IRF8 | 1 hits |
| 10 | ISG15 | 1 hits |
| 11 | NFKB1 | 1 hits |
| 12 | STAT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14763335 | The aim of this review is to describe 3 new syndromes with a genetic predisposition of infectious diseases: IL-12-IFN gamma axis deficiency (Mendelian susceptibility to mycobacterial disease), STAT1 deficiency (predisposition to viral disease) and NEMO and IRAK-4 deficiencies (predisposition to infections caused by pyogenic bacteria). |
| 2 | 14963119 | Mice treated intranasally with interleukin-10 or with a specific cell-permeable peptide that blocks the association of the catalytic subunit IKKbeta with the regulatory protein NEMO showed a striking reduction of lung NF-kappaB DNA binding activity, chemokine gene expression, and airway inflammation in response to RSV infection. |
| 3 | 16426002 | Tumor necrosis factor (TNF) production in PBMC supernatants was measured by an enzyme-linked immunosorbent assay after TLR ligand stimulation and was dependent on gene transcription and NF-kappaB activation. |
| 4 | 16426002 | Finally, three patients with a mutation in the IKBKG gene, encoding the NF-kappaB essential modulator (NEMO) protein, were evaluated as disease controls and were almost uniformly below the standard deviation of healthy donors for all ligands tested. |
| 5 | 16950813 | IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease. |
| 6 | 25453225 | Since 1996, nine MSMD-causing genes, including seven autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1, ISG15, and IRF8) and two X-linked (NEMO, and CYBB) genes have been discovered. |
| 7 | 25453225 | These disorders impair the production of (IL12B, IL12RB1, IRF8, ISG15, NEMO) or the response to (IFNGR1, IFNGR2, STAT1, IRF8, CYBB) IFN-γ. |
| 8 | 25453225 | Since 1996, nine MSMD-causing genes, including seven autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1, ISG15, and IRF8) and two X-linked (NEMO, and CYBB) genes have been discovered. |
| 9 | 25453225 | These disorders impair the production of (IL12B, IL12RB1, IRF8, ISG15, NEMO) or the response to (IFNGR1, IFNGR2, STAT1, IRF8, CYBB) IFN-γ. |