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Gene Information
Gene symbol: IL17RB
Gene name: interleukin 17 receptor B
HGNC ID: 18015
Synonyms: IL17RH1, EVI27, CRL4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CD8A | 1 hits |
| 3 | CXCR5 | 1 hits |
| 4 | PDCD1 | 1 hits |
| 5 | TNFRSF4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20392496 | IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo. |
| 2 | 20392496 | While IL-4 directs CD4 T cells to produce Th2 cytokines (including IL-4, IL-13, IL-5) in vitro it has been shown that production of these cytokines can be induced in vivo in the absence of IL-4/IL-13/STAT-6 signaling. |
| 3 | 20392496 | The present report shows that CD8 as well as CD4 T cells activated through their TCR, in vitro upregulate the Th2-features - IL-4, IL-13, IL-5, and GATA-3. |
| 4 | 20392496 | However, in vivo while alum-precipitated antigen strongly and selectively induces these Th2-features in CD4 T cells, CD8 T cells mount a markedly different response to this antigen. |
| 5 | 20392496 | This CD8 response is associated with strong proliferation and production of IFN-gamma, but no Th2-features are induced. |
| 6 | 20392496 | Alum-protein formulations are widely used in human vaccines and typically induce strong antibody responses characterized by the differentiation of IL-4-producing CD4 T cells and immunoglobulin class switching to IgG1. |
| 7 | 20392496 | Analysis of the in vivo response to alum-precipitated protein shows that while subsets of CD4 T cells strongly upregulate Th2 and follicular helper T cell features including the surface markers OX40, CXCR5, PD-1, IL-17RB and the transcription factor c-Maf, CD8 T cells do not. |
| 8 | 20392496 | These discrete differences between responding CD4 and CD8 T cells provide further insight into the differences between Th2 polarization of CD4 T cells directed by IL-4 in vitro and the induction of IL-4 production by CD4 T cells in vivo in response to alum-precipitated protein. |