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Gene Information
Gene symbol: IL20RA
Gene name: interleukin 20 receptor, alpha
HGNC ID: 6003
Synonyms: ZCYTOR7, IL-20R1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL20RB | 1 hits |
| 2 | IL22RA1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19124723 | The recently described cytokines IL-19, IL-20, and IL-24 share structural homology with IL-10 and are therefore classified as members of the IL-10 family of cytokines. |
| 2 | 19124723 | Although it has long been speculated that signaling by their heterodimeric receptor complexes (IL-20R1/IL-20R2 and IL-22R/IL-20R2) influences immunological processes, the target cells for this group of cytokines are still unclear. |
| 3 | 19124723 | By generating a knockout mouse strain deficient for the common IL-20R beta-chain (IL-20R2), we show that IFN-gamma and IL-2 secretion is significantly elevated after stimulation of IL-20R2-/--deficient CD8 and CD4 T cells with Con A or anti-CD3/CD28 in vitro. |
| 4 | 19124723 | IL-10 secretion by activated IL-20R2-/- CD4 cells was diminished. |
| 5 | 19124723 | Consistent with our in vitro results, significantly more Ag-specific CD8 IFN-gamma+ and CD4 IFN-gamma+ T cells developed to locally applied DNA vaccines in IL-20R2-deficient mice. |
| 6 | 19124723 | Thus, IL-20R2 signaling directly regulates CD8 and CD4 T cell answers in vitro and in vivo. |
| 7 | 19124723 | For the first time, we provide evidence that IL-19, IL-20, and IL-24 are part of a signaling network that normally down-modulates T cell responses in mice. |