Ignet

Gene Information

Gene symbol: IL20RB

Gene name: interleukin 20 receptor beta

HGNC ID: 6004

Synonyms: DIRS1, IL-20R2, MGC34923

Related Genes

#	Gene Symbol	Number of hits
1	CD28	1 hits
2	CD4	1 hits
3	CD8A	1 hits
4	IFNG	1 hits
5	IL10	1 hits
6	IL2	1 hits
7	IL20RA	1 hits
8	IL22RA1	1 hits

Related Sentences

#	PMID	Sentence
1	19124723	The recently described cytokines IL-19, IL-20, and IL-24 share structural homology with IL-10 and are therefore classified as members of the IL-10 family of cytokines.
2	19124723	Although it has long been speculated that signaling by their heterodimeric receptor complexes (IL-20R1/IL-20R2 and IL-22R/IL-20R2) influences immunological processes, the target cells for this group of cytokines are still unclear.
3	19124723	By generating a knockout mouse strain deficient for the common IL-20R beta-chain (IL-20R2), we show that IFN-gamma and IL-2 secretion is significantly elevated after stimulation of IL-20R2-/--deficient CD8 and CD4 T cells with Con A or anti-CD3/CD28 in vitro.
4	19124723	IL-10 secretion by activated IL-20R2-/- CD4 cells was diminished.
5	19124723	Consistent with our in vitro results, significantly more Ag-specific CD8 IFN-gamma+ and CD4 IFN-gamma+ T cells developed to locally applied DNA vaccines in IL-20R2-deficient mice.
6	19124723	Thus, IL-20R2 signaling directly regulates CD8 and CD4 T cell answers in vitro and in vivo.
7	19124723	For the first time, we provide evidence that IL-19, IL-20, and IL-24 are part of a signaling network that normally down-modulates T cell responses in mice.
8	19124723	The recently described cytokines IL-19, IL-20, and IL-24 share structural homology with IL-10 and are therefore classified as members of the IL-10 family of cytokines.
9	19124723	Although it has long been speculated that signaling by their heterodimeric receptor complexes (IL-20R1/IL-20R2 and IL-22R/IL-20R2) influences immunological processes, the target cells for this group of cytokines are still unclear.
10	19124723	By generating a knockout mouse strain deficient for the common IL-20R beta-chain (IL-20R2), we show that IFN-gamma and IL-2 secretion is significantly elevated after stimulation of IL-20R2-/--deficient CD8 and CD4 T cells with Con A or anti-CD3/CD28 in vitro.
11	19124723	IL-10 secretion by activated IL-20R2-/- CD4 cells was diminished.
12	19124723	Consistent with our in vitro results, significantly more Ag-specific CD8 IFN-gamma+ and CD4 IFN-gamma+ T cells developed to locally applied DNA vaccines in IL-20R2-deficient mice.
13	19124723	Thus, IL-20R2 signaling directly regulates CD8 and CD4 T cell answers in vitro and in vivo.
14	19124723	For the first time, we provide evidence that IL-19, IL-20, and IL-24 are part of a signaling network that normally down-modulates T cell responses in mice.
15	19124723	The recently described cytokines IL-19, IL-20, and IL-24 share structural homology with IL-10 and are therefore classified as members of the IL-10 family of cytokines.
16	19124723	Although it has long been speculated that signaling by their heterodimeric receptor complexes (IL-20R1/IL-20R2 and IL-22R/IL-20R2) influences immunological processes, the target cells for this group of cytokines are still unclear.
17	19124723	By generating a knockout mouse strain deficient for the common IL-20R beta-chain (IL-20R2), we show that IFN-gamma and IL-2 secretion is significantly elevated after stimulation of IL-20R2-/--deficient CD8 and CD4 T cells with Con A or anti-CD3/CD28 in vitro.
18	19124723	IL-10 secretion by activated IL-20R2-/- CD4 cells was diminished.
19	19124723	Consistent with our in vitro results, significantly more Ag-specific CD8 IFN-gamma+ and CD4 IFN-gamma+ T cells developed to locally applied DNA vaccines in IL-20R2-deficient mice.
20	19124723	Thus, IL-20R2 signaling directly regulates CD8 and CD4 T cell answers in vitro and in vivo.
21	19124723	For the first time, we provide evidence that IL-19, IL-20, and IL-24 are part of a signaling network that normally down-modulates T cell responses in mice.
22	19124723	The recently described cytokines IL-19, IL-20, and IL-24 share structural homology with IL-10 and are therefore classified as members of the IL-10 family of cytokines.
23	19124723	Although it has long been speculated that signaling by their heterodimeric receptor complexes (IL-20R1/IL-20R2 and IL-22R/IL-20R2) influences immunological processes, the target cells for this group of cytokines are still unclear.
24	19124723	By generating a knockout mouse strain deficient for the common IL-20R beta-chain (IL-20R2), we show that IFN-gamma and IL-2 secretion is significantly elevated after stimulation of IL-20R2-/--deficient CD8 and CD4 T cells with Con A or anti-CD3/CD28 in vitro.
25	19124723	IL-10 secretion by activated IL-20R2-/- CD4 cells was diminished.
26	19124723	Consistent with our in vitro results, significantly more Ag-specific CD8 IFN-gamma+ and CD4 IFN-gamma+ T cells developed to locally applied DNA vaccines in IL-20R2-deficient mice.
27	19124723	Thus, IL-20R2 signaling directly regulates CD8 and CD4 T cell answers in vitro and in vivo.
28	19124723	For the first time, we provide evidence that IL-19, IL-20, and IL-24 are part of a signaling network that normally down-modulates T cell responses in mice.
29	19124723	The recently described cytokines IL-19, IL-20, and IL-24 share structural homology with IL-10 and are therefore classified as members of the IL-10 family of cytokines.
30	19124723	Although it has long been speculated that signaling by their heterodimeric receptor complexes (IL-20R1/IL-20R2 and IL-22R/IL-20R2) influences immunological processes, the target cells for this group of cytokines are still unclear.
31	19124723	By generating a knockout mouse strain deficient for the common IL-20R beta-chain (IL-20R2), we show that IFN-gamma and IL-2 secretion is significantly elevated after stimulation of IL-20R2-/--deficient CD8 and CD4 T cells with Con A or anti-CD3/CD28 in vitro.
32	19124723	IL-10 secretion by activated IL-20R2-/- CD4 cells was diminished.
33	19124723	Consistent with our in vitro results, significantly more Ag-specific CD8 IFN-gamma+ and CD4 IFN-gamma+ T cells developed to locally applied DNA vaccines in IL-20R2-deficient mice.
34	19124723	Thus, IL-20R2 signaling directly regulates CD8 and CD4 T cell answers in vitro and in vivo.
35	19124723	For the first time, we provide evidence that IL-19, IL-20, and IL-24 are part of a signaling network that normally down-modulates T cell responses in mice.