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Gene Information

Gene symbol: IL28RA

Gene name: interleukin 28 receptor, alpha (interferon, lambda receptor)

HGNC ID: 18584

Related Genes

#	Gene Symbol	Number of hits
1	IFNG	1 hits
2	IL28B	1 hits

Related Sentences

#	PMID	Sentence
1	19304955	Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity.
2	19304955	IL-28B belongs to the newly described interferon lambda (IFNlambda) family of cytokines, and has not yet been assessed for its potential ability to influence adaptive immune responses or act as a vaccine adjuvant.
3	19304955	We show here that IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity.
4	19304955	We also show that IL-28B, unlike IL-12, is able to increase the percentage of splenic CD8(+) T cells in vaccinated animals, and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.
5	25503988	IL-28B, a member of the interferon (IFN)-λ family, has variable expression due to single nucleotide polymorphisms (SNPs).
6	25503988	While type-I IFNs are well known to modulate adaptive immunity, the impact of IL-28B on B- and T-cell vaccine responses is unclear.
7	25503988	In vitro, recombinant IL-28B increased Th1-cytokines (e.g.
8	25503988	IL-4, IL-5, and IL-13), H1N1-stimulated B-cell proliferation (reduced 70%), and IgG-production (reduced>70%).
9	25503988	Since IL-28B inhibited B-cell responses, we designed antagonistic peptides to block the IL-28 receptor α-subunit (IL28RA).
10	26038748	Common single nucleotide polymorphisms (SNPs) in the IFNL3, IFNL4 and the IFNL receptor α-subunit genes have been strongly associated with IFN-α-based treatment of chronic hepatitis C virus infection.