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Gene Information
Gene symbol: IL2RG
Gene name: interleukin 2 receptor, gamma
HGNC ID: 6010
Synonyms: CD132
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ERBB2 | 1 hits |
| 2 | IL2 | 1 hits |
| 3 | IL2RA | 1 hits |
| 4 | JAK3 | 1 hits |
| 5 | RAG2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23250629 | Total 20 mutations in interleukin-2 receptor subunit gamma (IL2RG) were identified in 22 patients, including 11 novel mutations. |
| 2 | 23772419 | Protective immune responses were orchestrated by T cells and their cytokines, and effected by antibodies against HER-2 gene product p185. |
| 3 | 23772419 | The availability of cancer-prone mice carrying a human HER-2 transgene is now fostering the design of novel vaccines against human p185. |
| 4 | 23772419 | A further bridge toward human cancer was recently provided by novel immunodeficient models, like Rag2(-/-);Il2rg(-/-) mice, which are permissive for metastatic spread of human HER-2+ cancer cells and can be engrafted with a functional human immune system, allowing for the first time the study of vaccines against oncoantigens to elicit human immune responses against human cancer cells in vivo. |
| 5 | 24481607 | Out of five male infants with T-B+NK- SCID phenotype, mutation analysis revealed interleukin-2 (common) gamma-chain receptor (IL2RG) mutations in 3 with positive X-linked family history, and Janus-kinase (JAK)-3 gene defects in the other two. |
| 6 | 24481607 | Six patients had T-B-NK+ SCID phenotype and further 6 features of OS, 11 of which had recombinase-activating gene (RAG1or RAG2) and 1 Artemis gene mutations. |