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Gene Information
Gene symbol: INSR
Gene name: insulin receptor
HGNC ID: 6091
Synonyms: CD220
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CPE | 1 hits |
| 2 | EGF | 1 hits |
| 3 | EGFR | 1 hits |
| 4 | IGF1R | 1 hits |
| 5 | INSRR | 1 hits |
| 6 | MAPK1 | 1 hits |
| 7 | PECAM1 | 1 hits |
| 8 | PTPN6 | 1 hits |
| 9 | UBE2Q1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12687122 | I have detected hitherto unreported identity of HCG-beta sequence with tetrapeptides of PECAM-1, galactosyl transferase-associated protein kinase, insulin receptor-related receptor and carboxypeptidase E. |
| 2 | 12687122 | The last 30 residue stretch of CTP was found for the first time to have 61.4-65.4% homology with subsequences of autoantigens SP-100, PM-SCL, D1 (64 kDa), lupus KU (p86), small nuclear ribonucleoprotein-associated proteins N, B and B', major centromere autoantigen B, centromere protein C, and dihydrolipoamide acetyl transferase component E2 of pyruvate, respectively. |
| 3 | 15005518 | Specific inhibitors for tyrosine kinase receptors (such as EGF receptor) are currently used with success as anti-tumor drugs. |
| 4 | 15005518 | Three RTK have been identified in S. mansoni: an EGF receptor, an insulin receptor and a third receptor with an original structure probably belonging to a new class of RTK never identified. |
| 5 | 17001305 | The action of the insulin-like growth factor (IGF) system has been implicated in many malignancies, and recent data have demonstrated that the IGF-I receptor (IGF-IR) is required for in vitro growth of the KS-derived KSIMM cell line. |
| 6 | 17001305 | The expression of the insulin receptor (IR) was strongly induced in latently infected E-DMVEC, whereas the expression levels of the IGF-IR remained unchanged. |
| 7 | 25730798 | An extract of Perilla stem inhibits Src homology phosphatase-1 (SHP)-1 and influences insulin signaling. |
| 8 | 25730798 | Protein tyrosine phosphatases (PTPs) are enzymes that catalyze protein tyrosine dephosphorylation of which Src homology phosphatase-1 (SHP-1) is one of the best-validated, a widely distributed intracellular tyrosine phosphatase that contains two SH2 domains. |
| 9 | 25730798 | Down regulation of SHP-1 tyrosine phosphatases was significantly increased sensitivity to insulin in insulin signaling pathway. |
| 10 | 25730798 | Through in vitro enzymatic reaction kinetics experiment, we found that the extract of Perilla stem was a potential inhibitor to δSHP-1, the catalytic domain of SHP-1 protein tyrosine phosphatase, and its IC(50) was 4ug/ml, and was more sensitive towards SHP-1than other PTPs, which indicated that SHP-1 might be a target of the extract of Perilla stem. |
| 11 | 25730798 | It can strengthened the level of tyrosine phosphorylation of insulin receptor (IR) and extracellular signal-regulated protein kinase (ERK) in HepG2 cells, and then activated the insulin signaling pathway through inhibiting the protein phosphorylation of SHP-1. |
| 12 | 25730798 | These results demonstrated that the extract of Perilla stem could play an important role for diabetes treatment through inhibiting the level of SHP-1 in insulin signaling pathway. |