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Gene Information
Gene symbol: INTS1
Gene name: integrator complex subunit 1
HGNC ID: 24555
Synonyms: DKFZp586J0619, KIAA1440, INT1, NET28
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HLA-A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15705910 | Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccine. |
| 2 | 15705910 | A phase I clinical trial with granulocyte-macrophage colony-stimulating factor tumor cell vaccines in patients with metastatic renal cell carcinoma (RCC) showed immune cell infiltration at vaccine sites and delayed-type hypersensitivity (DTH) responses to autologous tumor cells indicative of T-cell immunity. |
| 3 | 15705910 | A third line recognized a unique HLA-A*0101-restricted RCC antigen derived from a mutated KIAA1440 gene specific to the tumor. |
| 4 | 15705910 | In addition, two independent CTL lines and three clones were also generated from patient 26 and they recognized autologous tumor cells restricted through HLA-A*0205, HLA-A/B/C, and HLA-B/C. |
| 5 | 15705910 | These results show that paracrine granulocyte-macrophage colony-stimulating factor tumor vaccines may generate a diverse repertoire of tumor-reactive CD8+ T-cell responses and emphasize the importance of polyvalency in the design of cancer immunotherapies. |