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Gene Information
Gene symbol: IRAK4
Gene name: interleukin-1 receptor-associated kinase 4
HGNC ID: 17967
Synonyms: NY-REN-64
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IKBKG | 1 hits |
| 2 | IL1A | 1 hits |
| 3 | IL1B | 1 hits |
| 4 | IL1R1 | 1 hits |
| 5 | IL1RAPL2 | 1 hits |
| 6 | IRAK1 | 1 hits |
| 7 | STAT1 | 1 hits |
| 8 | TLR7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14763335 | The aim of this review is to describe 3 new syndromes with a genetic predisposition of infectious diseases: IL-12-IFN gamma axis deficiency (Mendelian susceptibility to mycobacterial disease), STAT1 deficiency (predisposition to viral disease) and NEMO and IRAK-4 deficiencies (predisposition to infections caused by pyogenic bacteria). |
| 2 | 16950813 | IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease. |
| 3 | 24596024 | Fatal pneumococcal meningitis in a 7-year-old girl with interleukin-1 receptor activated kinase deficiency (IRAK-4) despite prophylactic antibiotic and IgG responses to Streptococcus pneumoniae vaccines. |
| 4 | 25555811 | As a pivotal signaling mediator of toll-like receptor (TLR) and interleukin (IL)-1 receptor (IL-1R) signaling cascades, the IL-1R-associated kinase 4 (IRAK4) is engaged in the activation of host immunity. |
| 5 | 25737587 | We also showed that the RLR pathway was dampened by the activities of interleukin-1 receptor-associated kinases 1 and 4 (IRAK1 and IRAK4), which are downstream effectors of the TLR7 pathway, suggesting that both kinases play opposing roles downstream of specific PRRs. |