Ignet

Gene Information

Gene symbol: ITK

Gene name: IL2-inducible T-cell kinase

HGNC ID: 6171

Synonyms: EMT, PSCTK2, LYK

Related Genes

#	Gene Symbol	Number of hits
1	CD4	1 hits
2	CD8A	1 hits
3	EGFR	1 hits
4	HAVCR2	1 hits
5	IFNG	1 hits
6	IL4	1 hits
7	LGALS9	1 hits
8	LIMS1	1 hits
9	MUC1	1 hits
10	TBX1	1 hits
11	TP53	1 hits

Related Sentences

#	PMID	Sentence
1	16547221	IL-4 production in itk(-/-) Th2s could be rescued by the expression of kinase-active Itk.
2	17579028	A key role for Itk in both IFN gamma and IL-4 production by NKT cells.
3	17579028	The tyrosine kinase Itk is activated downstream of the TCR, and its absence in CD4(+) T cells results in impaired Th2, but not Th1 responses.
4	17579028	In this study, we investigated NKT cell function in the absence of Itk as impaired type 2 responses in vivo could be manifest through IL-4 defects in a number of cell types.
5	17579028	We show that Itk-deficient NKT cells up-regulate IL-4 mRNA in the thymus and express constitutive IL-4 and IFN-gamma transcripts in peripheral organs.
6	17579028	Strikingly, unlike conventional CD4(+) T cells, Itk-deficient NKT cells also have profound defects in IFN-gamma production.
7	17579028	Furthermore, both IL-4 and IFN-gamma production were markedly impaired following in vivo challenge with alpha-galactosyl ceramide.
8	17579028	These results suggest that NKT cells are highly dependent on Itk for IL-4- and IFN-gamma-mediated effector function.
9	17579028	A key role for Itk in both IFN gamma and IL-4 production by NKT cells.
10	17579028	The tyrosine kinase Itk is activated downstream of the TCR, and its absence in CD4(+) T cells results in impaired Th2, but not Th1 responses.
11	17579028	In this study, we investigated NKT cell function in the absence of Itk as impaired type 2 responses in vivo could be manifest through IL-4 defects in a number of cell types.
12	17579028	We show that Itk-deficient NKT cells up-regulate IL-4 mRNA in the thymus and express constitutive IL-4 and IFN-gamma transcripts in peripheral organs.
13	17579028	Strikingly, unlike conventional CD4(+) T cells, Itk-deficient NKT cells also have profound defects in IFN-gamma production.
14	17579028	Furthermore, both IL-4 and IFN-gamma production were markedly impaired following in vivo challenge with alpha-galactosyl ceramide.
15	17579028	These results suggest that NKT cells are highly dependent on Itk for IL-4- and IFN-gamma-mediated effector function.
16	17579028	A key role for Itk in both IFN gamma and IL-4 production by NKT cells.
17	17579028	The tyrosine kinase Itk is activated downstream of the TCR, and its absence in CD4(+) T cells results in impaired Th2, but not Th1 responses.
18	17579028	In this study, we investigated NKT cell function in the absence of Itk as impaired type 2 responses in vivo could be manifest through IL-4 defects in a number of cell types.
19	17579028	We show that Itk-deficient NKT cells up-regulate IL-4 mRNA in the thymus and express constitutive IL-4 and IFN-gamma transcripts in peripheral organs.
20	17579028	Strikingly, unlike conventional CD4(+) T cells, Itk-deficient NKT cells also have profound defects in IFN-gamma production.
21	17579028	Furthermore, both IL-4 and IFN-gamma production were markedly impaired following in vivo challenge with alpha-galactosyl ceramide.
22	17579028	These results suggest that NKT cells are highly dependent on Itk for IL-4- and IFN-gamma-mediated effector function.
23	17579028	A key role for Itk in both IFN gamma and IL-4 production by NKT cells.
24	17579028	The tyrosine kinase Itk is activated downstream of the TCR, and its absence in CD4(+) T cells results in impaired Th2, but not Th1 responses.
25	17579028	In this study, we investigated NKT cell function in the absence of Itk as impaired type 2 responses in vivo could be manifest through IL-4 defects in a number of cell types.
26	17579028	We show that Itk-deficient NKT cells up-regulate IL-4 mRNA in the thymus and express constitutive IL-4 and IFN-gamma transcripts in peripheral organs.
27	17579028	Strikingly, unlike conventional CD4(+) T cells, Itk-deficient NKT cells also have profound defects in IFN-gamma production.
28	17579028	Furthermore, both IL-4 and IFN-gamma production were markedly impaired following in vivo challenge with alpha-galactosyl ceramide.
29	17579028	These results suggest that NKT cells are highly dependent on Itk for IL-4- and IFN-gamma-mediated effector function.
30	19237299	With a focus on Th2 cells and the kinase ITK, we review recent observations that point to differences between the signals needed for the initiation and implementation of cytokine programs in CD4+ T cells.
31	20446067	Current research investigating the biology of bladder cancer, including the role of p53, EMT, EGFR-related pathways, and anti-angiogenic pathways, may potentially impact the future development of novel agents targeting urothelial malignancies.
32	24125763	Previous studies have demonstrated that brachyury is a driver of the epithelial-mesenchymal transition (EMT), a process associated with cancer progression.
33	24125763	We demonstrate that human dendritic cells treated with recombinant yeast-brachyury can activate and expand brachyury-specific CD4+ and CD8+ T cells in vitro that, in turn, can effectively lyse human tumor cells expressing the brachyury protein.
34	24125763	Vaccination of mice with recombinant yeast-brachyury is also shown here to elicit brachyury-specific CD4+ and CD8+ T-cell responses, and to induce anti-tumor immunity in the absence of toxicity.
35	25279150	Induction of HLA-A*33-restricted cytotoxic lymphocytes against renal cell carcinoma targeting galectin 9 and PINCH.
36	25279150	Galectin 9, a ligand of T cell immunoglobulin and mucin domain 3 (TIM-3), and PINCH, an epithelial-to-mesenchymal transition (EMT)-promoting molecule, are expressed at much higher levels in cancerous lesions of clear cell type renal cell carcinoma (RCC) compared to normal renal tissues, and their expression levels are extremely low in normal tissues, except for galectin 9 in the spleen.
37	25279150	Galectin 9- and PINCH-derived peptides have previously been shown to induce human leukocyte antigen (HLA)-A2402-restricted and HLA-A0201-restricted cytotoxic lymphocytes (CTLs) with specific and highly cytotoxic activities toward RCC cells.
38	25567129	The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.
39	25567129	Here, we have examined the role of Itk, a tyrosine kinase critical for TcR signaling, in CD8(+) effector and memory T cell differentiation during Listeria monocytogenes infection.
40	25567129	We found that the reduced TcR signal strength in Itk deficient naïve CD8(+) T cells enhances the generation of memory T cells during infection.
41	25567129	Our data suggests that Itk-mediated signals control the expression of Eomesodermin and IL-7Rα, thus regulating the development of memory CD8(+) T cells, but not subsequent response of memory cells.
42	25567129	The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.
43	25567129	Here, we have examined the role of Itk, a tyrosine kinase critical for TcR signaling, in CD8(+) effector and memory T cell differentiation during Listeria monocytogenes infection.
44	25567129	We found that the reduced TcR signal strength in Itk deficient naïve CD8(+) T cells enhances the generation of memory T cells during infection.
45	25567129	Our data suggests that Itk-mediated signals control the expression of Eomesodermin and IL-7Rα, thus regulating the development of memory CD8(+) T cells, but not subsequent response of memory cells.
46	25567129	The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.
47	25567129	Here, we have examined the role of Itk, a tyrosine kinase critical for TcR signaling, in CD8(+) effector and memory T cell differentiation during Listeria monocytogenes infection.
48	25567129	We found that the reduced TcR signal strength in Itk deficient naïve CD8(+) T cells enhances the generation of memory T cells during infection.
49	25567129	Our data suggests that Itk-mediated signals control the expression of Eomesodermin and IL-7Rα, thus regulating the development of memory CD8(+) T cells, but not subsequent response of memory cells.
50	26130065	The nuclear transcription factor brachyury has previously been shown to be a strong mediator of the epithelial-to-mesenchymal transition (EMT) in human carcinoma cells and a strong negative prognostic factor in several tumor types.