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Gene Information
Gene symbol: ITPR1
Gene name: inositol 1,4,5-trisphosphate receptor, type 1
HGNC ID: 6180
Synonyms: Insp3r1, IP3R1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IPPK | 1 hits |
| 2 | RYR1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16835063 | Transcriptional and immunocytochemical analyses show that murine myeloid immature DCs (IDCs) and mature DCs (MDCs) express inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) Ca2+ channels, known targets of THI. |
| 2 | 16835063 | IDCs express the RyR1 isoform in a punctate distribution that is densest near plasma membranes and within dendritic processes, whereas IP3Rs are more generally distributed. |
| 3 | 16835063 | THI and Ry, in combination, produced additive effects leading to uncoupling of IP3R and RyR1 signals. |
| 4 | 16835063 | THI altered ATP-mediated interleukin-6 secretion, initially enhancing the rate of cytokine secretion but suppressing cytokine secretion overall in DCs.DCs are exquisitely sensitive to THI, with one mechanism involving the uncoupling of positive and negative regulation of Ca2+ signals contributed by RyR1. |
| 5 | 16835063 | Transcriptional and immunocytochemical analyses show that murine myeloid immature DCs (IDCs) and mature DCs (MDCs) express inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) Ca2+ channels, known targets of THI. |
| 6 | 16835063 | IDCs express the RyR1 isoform in a punctate distribution that is densest near plasma membranes and within dendritic processes, whereas IP3Rs are more generally distributed. |
| 7 | 16835063 | THI and Ry, in combination, produced additive effects leading to uncoupling of IP3R and RyR1 signals. |
| 8 | 16835063 | THI altered ATP-mediated interleukin-6 secretion, initially enhancing the rate of cytokine secretion but suppressing cytokine secretion overall in DCs.DCs are exquisitely sensitive to THI, with one mechanism involving the uncoupling of positive and negative regulation of Ca2+ signals contributed by RyR1. |
| 9 | 16835063 | Transcriptional and immunocytochemical analyses show that murine myeloid immature DCs (IDCs) and mature DCs (MDCs) express inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) Ca2+ channels, known targets of THI. |
| 10 | 16835063 | IDCs express the RyR1 isoform in a punctate distribution that is densest near plasma membranes and within dendritic processes, whereas IP3Rs are more generally distributed. |
| 11 | 16835063 | THI and Ry, in combination, produced additive effects leading to uncoupling of IP3R and RyR1 signals. |
| 12 | 16835063 | THI altered ATP-mediated interleukin-6 secretion, initially enhancing the rate of cytokine secretion but suppressing cytokine secretion overall in DCs.DCs are exquisitely sensitive to THI, with one mechanism involving the uncoupling of positive and negative regulation of Ca2+ signals contributed by RyR1. |