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Gene Information

Gene symbol: KHDRBS1

Gene name: KH domain containing, RNA binding, signal transduction associated 1

HGNC ID: 18116

Synonyms: Sam68, p62, FLJ34027

Related Genes

#	Gene Symbol	Number of hits
1	APP	1 hits
2	C1QBP	1 hits
3	CCNH	1 hits
4	EIF2AK2	1 hits
5	GTF2H2	1 hits
6	IRF9	1 hits
7	MAPK1	1 hits
8	PSEN1	1 hits
9	PSMC5	1 hits
10	TM9SF2	1 hits

Related Sentences

#	PMID	Sentence
1	11447174	Seven proteins, p76, p62, p48, p45, p41, p37, and p32, were identified as targets of the humoral response during natural infection.
2	11447174	Most of the other immunodominant proteins, including p48 and p45, were localized to the inner membrane.
3	21543505	NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.
4	21543505	Its NSs protein has previously been identified as a major virulence factor that suppresses host defense through three distinct mechanisms: it directly inhibits beta interferon (IFN-β) promoter activity, it promotes the degradation of double-stranded RNA-dependent protein kinase (PKR), and it suppresses host transcription by disrupting the assembly of the basal transcription factor TFIIH through sequestration of its p44 subunit.
5	21543505	Here, we report that in addition to PKR, NSs also promotes the degradation of the TFIIH subunit p62.
6	21543505	These data suggest that the RVFV NSs protein is able to interact with the TFIIH subunit p62 inside infected cells and promotes its degradation, which can occur directly in the nucleus.
7	21543505	NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.
8	21543505	Its NSs protein has previously been identified as a major virulence factor that suppresses host defense through three distinct mechanisms: it directly inhibits beta interferon (IFN-β) promoter activity, it promotes the degradation of double-stranded RNA-dependent protein kinase (PKR), and it suppresses host transcription by disrupting the assembly of the basal transcription factor TFIIH through sequestration of its p44 subunit.
9	21543505	Here, we report that in addition to PKR, NSs also promotes the degradation of the TFIIH subunit p62.
10	21543505	These data suggest that the RVFV NSs protein is able to interact with the TFIIH subunit p62 inside infected cells and promotes its degradation, which can occur directly in the nucleus.
11	21543505	NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.
12	21543505	Its NSs protein has previously been identified as a major virulence factor that suppresses host defense through three distinct mechanisms: it directly inhibits beta interferon (IFN-β) promoter activity, it promotes the degradation of double-stranded RNA-dependent protein kinase (PKR), and it suppresses host transcription by disrupting the assembly of the basal transcription factor TFIIH through sequestration of its p44 subunit.
13	21543505	Here, we report that in addition to PKR, NSs also promotes the degradation of the TFIIH subunit p62.
14	21543505	These data suggest that the RVFV NSs protein is able to interact with the TFIIH subunit p62 inside infected cells and promotes its degradation, which can occur directly in the nucleus.
15	26254061	Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice.
16	26254061	In this study, we first demonstrated that oral vaccination with rAAV/Aß decreased the p62 level and up-regulated the LC3B-II/LC3B-I ratio in APP/PS1 mouse brain, suggesting enhanced autophagy.
17	26254061	Further, inhibition of the Akt/mTOR pathway may account for autophagy enhancement.
18	26254061	We also found increased anti-Aß antibodies in the sera of APP/PS1 mice with oral vaccination, accompanied by elevation of complement factors C1q and C3 levels in the brain.