Ignet

Gene Information

Gene symbol: KIR2DL1

Gene name: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1

HGNC ID: 6329

Synonyms: cl-42, nkat1, 47.11, p58.1, CD158A

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	HLA-A	1 hits
3	HLA-C	1 hits
4	ICT1	1 hits
5	IL15	1 hits
6	KIR2DL2	1 hits
7	KIR2DL3	1 hits
8	KIR2DL4	1 hits
9	KIR2DL5A	1 hits
10	KIR2DS1	1 hits
11	KIR2DS2	1 hits
12	KIR2DS3	1 hits
13	KIR2DS4	1 hits
14	KIR2DS5	1 hits
15	KIR3DL1	1 hits
16	KLRB1	1 hits
17	KLRC1	1 hits
18	LILRB1	1 hits
19	NCR1	1 hits
20	NCR2	1 hits

Related Sentences

#	PMID	Sentence
1	18524833	Here, we demonstrate that after influenza virus infection the binding of the two NK inhibitory receptors, KIR2DL1 and the LIR1, to the infected cells is specifically increased.
2	23594113	Our data showed that the inhibitory gene frequency of genes KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5 and KIR2DL2 was 0.930, 0.889, 0.789, 0.206 and 0.095, respectively, and the activating gene frequency of KIR2DS4, KIR3DS1, KIR2DS1, KIR2DS5, KIR2DS2 and KIR2DS3 was 0.795, 0.218, 0.196, 0.165, 0.095 and 0.087, respectively.
3	23784853	We decided to assess the levels of NK and NKT lymphocytes and the expression levels of different membrane receptors (NKp44, NKp46, NKG2A, killer cell immune-like receptor [KIR] 3DL1/DS1, KIR2DL1/DS1, and CD161) in peripheral blood samples of patients with influenza (n = 17) and healthy individuals immunized against this virus (seasonal and [H1N1]pdm2009 influenza vaccines; n = 15 and 12, respectively).
4	23784853	We found that the patients with severe influenza (n = 9) showed significant increases in the percentages of NKp46(+) NKp44(+) NK cells and the proportions of NK and NKT lymphocytes expressing KIR2DL1 and KIR3DL1 and reductions in the percentages of NKp46(+) NKp44(-) NK cells compared to those in the healthy controls (n = 27).
5	23784853	We decided to assess the levels of NK and NKT lymphocytes and the expression levels of different membrane receptors (NKp44, NKp46, NKG2A, killer cell immune-like receptor [KIR] 3DL1/DS1, KIR2DL1/DS1, and CD161) in peripheral blood samples of patients with influenza (n = 17) and healthy individuals immunized against this virus (seasonal and [H1N1]pdm2009 influenza vaccines; n = 15 and 12, respectively).
6	23784853	We found that the patients with severe influenza (n = 9) showed significant increases in the percentages of NKp46(+) NKp44(+) NK cells and the proportions of NK and NKT lymphocytes expressing KIR2DL1 and KIR3DL1 and reductions in the percentages of NKp46(+) NKp44(-) NK cells compared to those in the healthy controls (n = 27).
7	24682434	HLA class I, KIR, and genome-wide SNP diversity in the RV144 Thai phase 3 HIV vaccine clinical trial.
8	24682434	Human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptor (KIR) genes, as well as 96 genome-wide ancestry informative markers (AIMs) were genotyped in 450 placebo HIV-1-uninfected individuals to identify the immunogenetic diversity and population structure of this cohort.
9	24682434	Framework genes KIR2DL4, 3DL2, and 3DL3 were present in all samples, and KIR2DL1, 2DL3, 3DL1, 2DS4, and 2DP1 occurred at frequencies greater than 90 %.
10	26453750	Human cells expressing HLA class I ligands for inhibitory receptors KIR2DL1, KIR2DL2/3, or CD94-NKG2A were transfected with IL-15Rα.
11	26453750	Proliferation of primary NK cells in response to transpresented IL-15 was reduced by engagement of either KIR2DL1 or KIR2DL2/3 by cognate HLA-C ligands.
12	26453750	Inhibitory KIR-HLA-C interactions did not reduce the proliferation induced by soluble IL-15.
13	26453750	Therefore, transpresentation of IL-15 is subject to downregulation by MHC class I-specific inhibitory receptors.
14	26453750	Similarly, proliferation of the NKG2A(+) cell line NKL induced by IL-15 transpresentation was inhibited by HLA-E.
15	26453750	Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.
16	26453750	Human cells expressing HLA class I ligands for inhibitory receptors KIR2DL1, KIR2DL2/3, or CD94-NKG2A were transfected with IL-15Rα.
17	26453750	Proliferation of primary NK cells in response to transpresented IL-15 was reduced by engagement of either KIR2DL1 or KIR2DL2/3 by cognate HLA-C ligands.
18	26453750	Inhibitory KIR-HLA-C interactions did not reduce the proliferation induced by soluble IL-15.
19	26453750	Therefore, transpresentation of IL-15 is subject to downregulation by MHC class I-specific inhibitory receptors.
20	26453750	Similarly, proliferation of the NKG2A(+) cell line NKL induced by IL-15 transpresentation was inhibited by HLA-E.
21	26453750	Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.
22	26453750	Human cells expressing HLA class I ligands for inhibitory receptors KIR2DL1, KIR2DL2/3, or CD94-NKG2A were transfected with IL-15Rα.
23	26453750	Proliferation of primary NK cells in response to transpresented IL-15 was reduced by engagement of either KIR2DL1 or KIR2DL2/3 by cognate HLA-C ligands.
24	26453750	Inhibitory KIR-HLA-C interactions did not reduce the proliferation induced by soluble IL-15.
25	26453750	Therefore, transpresentation of IL-15 is subject to downregulation by MHC class I-specific inhibitory receptors.
26	26453750	Similarly, proliferation of the NKG2A(+) cell line NKL induced by IL-15 transpresentation was inhibited by HLA-E.
27	26453750	Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.