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Gene Information

Gene symbol: KIR2DL2

Gene name: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2

HGNC ID: 6330

Related Genes

# Gene Symbol Number of hits
1 HLA-A 1 hits
2 HLA-C 1 hits
3 IL15 1 hits
4 KIR2DL1 1 hits
5 KIR2DL3 1 hits
6 KIR2DL5A 1 hits
7 KIR2DS1 1 hits
8 KIR2DS2 1 hits
9 KIR2DS3 1 hits
10 KIR2DS4 1 hits
11 KIR2DS5 1 hits
12 KIR3DL1 1 hits

Related Sentences

# PMID Sentence
1 23594113 Our data showed that the inhibitory gene frequency of genes KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5 and KIR2DL2 was 0.930, 0.889, 0.789, 0.206 and 0.095, respectively, and the activating gene frequency of KIR2DS4, KIR3DS1, KIR2DS1, KIR2DS5, KIR2DS2 and KIR2DS3 was 0.795, 0.218, 0.196, 0.165, 0.095 and 0.087, respectively.
2 26453750 Human cells expressing HLA class I ligands for inhibitory receptors KIR2DL1, KIR2DL2/3, or CD94-NKG2A were transfected with IL-15Rα.
3 26453750 Proliferation of primary NK cells in response to transpresented IL-15 was reduced by engagement of either KIR2DL1 or KIR2DL2/3 by cognate HLA-C ligands.
4 26453750 Inhibitory KIR-HLA-C interactions did not reduce the proliferation induced by soluble IL-15.
5 26453750 Therefore, transpresentation of IL-15 is subject to downregulation by MHC class I-specific inhibitory receptors.
6 26453750 Similarly, proliferation of the NKG2A(+) cell line NKL induced by IL-15 transpresentation was inhibited by HLA-E.
7 26453750 Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.
8 26453750 Human cells expressing HLA class I ligands for inhibitory receptors KIR2DL1, KIR2DL2/3, or CD94-NKG2A were transfected with IL-15Rα.
9 26453750 Proliferation of primary NK cells in response to transpresented IL-15 was reduced by engagement of either KIR2DL1 or KIR2DL2/3 by cognate HLA-C ligands.
10 26453750 Inhibitory KIR-HLA-C interactions did not reduce the proliferation induced by soluble IL-15.
11 26453750 Therefore, transpresentation of IL-15 is subject to downregulation by MHC class I-specific inhibitory receptors.
12 26453750 Similarly, proliferation of the NKG2A(+) cell line NKL induced by IL-15 transpresentation was inhibited by HLA-E.
13 26453750 Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.