Gene name: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
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PMID |
Sentence |
1 |
23594113
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Our data showed that the inhibitory gene frequency of genes KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5 and KIR2DL2 was 0.930, 0.889, 0.789, 0.206 and 0.095, respectively, and the activating gene frequency of KIR2DS4, KIR3DS1, KIR2DS1, KIR2DS5, KIR2DS2 and KIR2DS3 was 0.795, 0.218, 0.196, 0.165, 0.095 and 0.087, respectively.
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2 |
26453750
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Human cells expressing HLA class I ligands for inhibitory receptors KIR2DL1, KIR2DL2/3, or CD94-NKG2A were transfected with IL-15Rα.
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3 |
26453750
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Proliferation of primary NK cells in response to transpresented IL-15 was reduced by engagement of either KIR2DL1 or KIR2DL2/3 by cognate HLA-C ligands.
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4 |
26453750
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Inhibitory KIR-HLA-C interactions did not reduce the proliferation induced by soluble IL-15.
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5 |
26453750
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Therefore, transpresentation of IL-15 is subject to downregulation by MHC class I-specific inhibitory receptors.
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6 |
26453750
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Similarly, proliferation of the NKG2A(+) cell line NKL induced by IL-15 transpresentation was inhibited by HLA-E.
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7 |
26453750
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Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.
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8 |
26453750
|
Human cells expressing HLA class I ligands for inhibitory receptors KIR2DL1, KIR2DL2/3, or CD94-NKG2A were transfected with IL-15Rα.
|
9 |
26453750
|
Proliferation of primary NK cells in response to transpresented IL-15 was reduced by engagement of either KIR2DL1 or KIR2DL2/3 by cognate HLA-C ligands.
|
10 |
26453750
|
Inhibitory KIR-HLA-C interactions did not reduce the proliferation induced by soluble IL-15.
|
11 |
26453750
|
Therefore, transpresentation of IL-15 is subject to downregulation by MHC class I-specific inhibitory receptors.
|
12 |
26453750
|
Similarly, proliferation of the NKG2A(+) cell line NKL induced by IL-15 transpresentation was inhibited by HLA-E.
|
13 |
26453750
|
Coengagement of inhibitory receptors, either KIR2DL1 or CD94-NKG2A, did not inhibit phosphorylation of Stat5 but inhibited selectively phosphorylation of Akt and S6 ribosomal protein.
|