Ignet

Gene Information

Gene symbol: KLRC2

Gene name: killer cell lectin-like receptor subfamily C, member 2

HGNC ID: 6375

Synonyms: NKG2-C, CD159c

Related Genes

#	Gene Symbol	Number of hits
1	B3GAT1	1 hits
2	CCR7	1 hits
3	CD27	1 hits
4	CXCR6	1 hits
5	KIR2DS2	1 hits
6	KIR3DL1	1 hits
7	KLRK1	1 hits
8	NCAM1	1 hits
9	NCR1	1 hits
10	NCR2	1 hits
11	SELL	1 hits

Related Sentences

#	PMID	Sentence
1	17462078	Differential induction of CD94 and NKG2 in CD4 helper T cells.
2	17462078	In this study we investigated CD94 and NKG2 gene expression in memory CD4 T-cell clones established from the spleens of C57BL/10 (H-2(b)) and BALB/c (H-2(d)) mice infected with influenza A virus (H3N2).
3	17462078	CD94 and NKG2A/C/E proteins form heterodimeric membrane receptors that are involved in virus recognition.
4	17462078	CD94 and NKG2 expression have been well characterized in natural killer (NK) and cytotoxic T cells.
5	17462078	Despite CD94 being potentially an important marker for Th1 cells involved in virus infection, however, there has been little investigation of its expression or function in the CD4 T-cell lineage and no studies have looked at in-vivo-generated Th cells or memory cells.
6	17462078	We show in this study that in-vivo-generated CD4 Th1 cells, but not Th2 cells, exhibited full-length CD94 and NKG2A gene expression following activation with viral peptide.
7	17462078	Another member of the NK receptor family, NKG2D, but not NKG2C or E, was also differentially expressed in Th1 cells.
8	17462078	We show here that CD94 and NKG2A may exist as multiple isoforms with the potential to distinguish helper T-cell subsets.
9	25781472	In the absence of significant changes in other NK cell markers (CD45RO, NKp44, CXCR6, CD57, NKG2C, CCR7, CD62L and CD27), influenza vaccines induced memory NK cells with the distinct feature of intracellular NKp46 expression.
10	25855356	NK cells contribute to postvaccination immune responses after activation by IL-2 from Ag-specific memory T cells or by cross-linking of the low-affinity IgG receptor, CD16, by Ag-Ab immune complexes.
11	25855356	CD56(dim)CD57(+) NK cells are less responsive to IL-2 and produce less IFN-γ in response to T cell-mediated activation than do CD56(bright) or CD56(dim)CD57(-) NK cells.
12	25855356	Human CMV (HCMV), a highly prevalent herpes virus causing lifelong, usually latent, infections, drives the expansion of the CD56(dim)CD57(+)NKG2C(+) NK cell population, skewing the NK cell repertoire in favor of cytotoxic responses at the expense of cytokine-driven responses.
13	25855356	Higher expression of CD57/NKG2C and lower expression of IL-18Rα on NK cells from HCMV seropositive subjects do not fully explain these impaired responses, which are likely the result of multiple receptor-ligand interactions.
14	25855356	NK cells contribute to postvaccination immune responses after activation by IL-2 from Ag-specific memory T cells or by cross-linking of the low-affinity IgG receptor, CD16, by Ag-Ab immune complexes.
15	25855356	CD56(dim)CD57(+) NK cells are less responsive to IL-2 and produce less IFN-γ in response to T cell-mediated activation than do CD56(bright) or CD56(dim)CD57(-) NK cells.
16	25855356	Human CMV (HCMV), a highly prevalent herpes virus causing lifelong, usually latent, infections, drives the expansion of the CD56(dim)CD57(+)NKG2C(+) NK cell population, skewing the NK cell repertoire in favor of cytotoxic responses at the expense of cytokine-driven responses.
17	25855356	Higher expression of CD57/NKG2C and lower expression of IL-18Rα on NK cells from HCMV seropositive subjects do not fully explain these impaired responses, which are likely the result of multiple receptor-ligand interactions.
18	26055301	Previously, we reported an increase of natural killer (NK) cells expressing NKG2C, CD57, and inhibitory killer cell immunoglobulin-like receptors (KIRs) in response to CMV reactivation after HCT.
19	26055301	This cohort was utilized to evaluate CMV-dependent increases in KIR-expressing NK cells exhibiting an adaptive phenotype (NKG2C(+)CD57(+)).
20	26055301	Previously, we reported an increase of natural killer (NK) cells expressing NKG2C, CD57, and inhibitory killer cell immunoglobulin-like receptors (KIRs) in response to CMV reactivation after HCT.
21	26055301	This cohort was utilized to evaluate CMV-dependent increases in KIR-expressing NK cells exhibiting an adaptive phenotype (NKG2C(+)CD57(+)).