Ignet

Gene Information

Gene symbol: KLRD1

Gene name: killer cell lectin-like receptor subfamily D, member 1

HGNC ID: 6378

Related Genes

#	Gene Symbol	Number of hits
1	ABL2	1 hits
2	CCR5	1 hits
3	CD244	1 hits
4	CD27	1 hits
5	CD4	1 hits
6	CD8A	1 hits
7	CXCR3	1 hits
8	EOMES	1 hits
9	GNLY	1 hits
10	GZMA	1 hits
11	GZMB	1 hits
12	HLA-A	1 hits
13	HLA-E	1 hits
14	IFNG	1 hits
15	IL7R	1 hits
16	KLRC1	1 hits
17	LAMP1	1 hits
18	NCR1	1 hits
19	PRF1	1 hits
20	ZNF395	1 hits

Related Sentences

#	PMID	Sentence
1	12097371	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
2	12097371	Following acute infection of C57BL/6 and BALB/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8(+) T cells expressed CD94/NKG2.
3	12097371	Expression of CD94/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker.
4	12097371	By means of cell sorting and quantitative PCR, we found that NP118-specific CD8(+) T cells primarily express transcripts for inhibitory NKG2 receptor isoforms.
5	12097371	CD94/NKG2 expression was also observed on Ag-specific CD8(+) T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8(+) T cells following infection with viral or bacterial pathogens.
6	12097371	Expression of CD94/NKG2 on memory-specific CD8(+) T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance.
7	12097371	Furthermore, we found no evidence that CD94/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
8	12097371	Finally, down-regulation of CD94/NKG2 was found to occur only during chronic LCMV infection.
9	12097371	Altogether, this study suggests that CD94/NKG2 expression is not necessarily correlated with inhibition of T cell function.
10	12097371	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
11	12097371	Following acute infection of C57BL/6 and BALB/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8(+) T cells expressed CD94/NKG2.
12	12097371	Expression of CD94/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker.
13	12097371	By means of cell sorting and quantitative PCR, we found that NP118-specific CD8(+) T cells primarily express transcripts for inhibitory NKG2 receptor isoforms.
14	12097371	CD94/NKG2 expression was also observed on Ag-specific CD8(+) T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8(+) T cells following infection with viral or bacterial pathogens.
15	12097371	Expression of CD94/NKG2 on memory-specific CD8(+) T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance.
16	12097371	Furthermore, we found no evidence that CD94/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
17	12097371	Finally, down-regulation of CD94/NKG2 was found to occur only during chronic LCMV infection.
18	12097371	Altogether, this study suggests that CD94/NKG2 expression is not necessarily correlated with inhibition of T cell function.
19	12097371	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
20	12097371	Following acute infection of C57BL/6 and BALB/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8(+) T cells expressed CD94/NKG2.
21	12097371	Expression of CD94/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker.
22	12097371	By means of cell sorting and quantitative PCR, we found that NP118-specific CD8(+) T cells primarily express transcripts for inhibitory NKG2 receptor isoforms.
23	12097371	CD94/NKG2 expression was also observed on Ag-specific CD8(+) T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8(+) T cells following infection with viral or bacterial pathogens.
24	12097371	Expression of CD94/NKG2 on memory-specific CD8(+) T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance.
25	12097371	Furthermore, we found no evidence that CD94/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
26	12097371	Finally, down-regulation of CD94/NKG2 was found to occur only during chronic LCMV infection.
27	12097371	Altogether, this study suggests that CD94/NKG2 expression is not necessarily correlated with inhibition of T cell function.
28	12097371	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
29	12097371	Following acute infection of C57BL/6 and BALB/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8(+) T cells expressed CD94/NKG2.
30	12097371	Expression of CD94/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker.
31	12097371	By means of cell sorting and quantitative PCR, we found that NP118-specific CD8(+) T cells primarily express transcripts for inhibitory NKG2 receptor isoforms.
32	12097371	CD94/NKG2 expression was also observed on Ag-specific CD8(+) T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8(+) T cells following infection with viral or bacterial pathogens.
33	12097371	Expression of CD94/NKG2 on memory-specific CD8(+) T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance.
34	12097371	Furthermore, we found no evidence that CD94/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
35	12097371	Finally, down-regulation of CD94/NKG2 was found to occur only during chronic LCMV infection.
36	12097371	Altogether, this study suggests that CD94/NKG2 expression is not necessarily correlated with inhibition of T cell function.
37	12097371	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
38	12097371	Following acute infection of C57BL/6 and BALB/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8(+) T cells expressed CD94/NKG2.
39	12097371	Expression of CD94/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker.
40	12097371	By means of cell sorting and quantitative PCR, we found that NP118-specific CD8(+) T cells primarily express transcripts for inhibitory NKG2 receptor isoforms.
41	12097371	CD94/NKG2 expression was also observed on Ag-specific CD8(+) T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8(+) T cells following infection with viral or bacterial pathogens.
42	12097371	Expression of CD94/NKG2 on memory-specific CD8(+) T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance.
43	12097371	Furthermore, we found no evidence that CD94/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
44	12097371	Finally, down-regulation of CD94/NKG2 was found to occur only during chronic LCMV infection.
45	12097371	Altogether, this study suggests that CD94/NKG2 expression is not necessarily correlated with inhibition of T cell function.
46	12097371	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
47	12097371	Following acute infection of C57BL/6 and BALB/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8(+) T cells expressed CD94/NKG2.
48	12097371	Expression of CD94/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker.
49	12097371	By means of cell sorting and quantitative PCR, we found that NP118-specific CD8(+) T cells primarily express transcripts for inhibitory NKG2 receptor isoforms.
50	12097371	CD94/NKG2 expression was also observed on Ag-specific CD8(+) T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8(+) T cells following infection with viral or bacterial pathogens.
51	12097371	Expression of CD94/NKG2 on memory-specific CD8(+) T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance.
52	12097371	Furthermore, we found no evidence that CD94/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
53	12097371	Finally, down-regulation of CD94/NKG2 was found to occur only during chronic LCMV infection.
54	12097371	Altogether, this study suggests that CD94/NKG2 expression is not necessarily correlated with inhibition of T cell function.
55	12097371	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
56	12097371	Following acute infection of C57BL/6 and BALB/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8(+) T cells expressed CD94/NKG2.
57	12097371	Expression of CD94/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker.
58	12097371	By means of cell sorting and quantitative PCR, we found that NP118-specific CD8(+) T cells primarily express transcripts for inhibitory NKG2 receptor isoforms.
59	12097371	CD94/NKG2 expression was also observed on Ag-specific CD8(+) T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8(+) T cells following infection with viral or bacterial pathogens.
60	12097371	Expression of CD94/NKG2 on memory-specific CD8(+) T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance.
61	12097371	Furthermore, we found no evidence that CD94/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
62	12097371	Finally, down-regulation of CD94/NKG2 was found to occur only during chronic LCMV infection.
63	12097371	Altogether, this study suggests that CD94/NKG2 expression is not necessarily correlated with inhibition of T cell function.
64	12097371	CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
65	12097371	Following acute infection of C57BL/6 and BALB/cJ mice with lymphocytic choriomeningitis virus (LCMV), we observed that Ag-specific CD8(+) T cells expressed CD94/NKG2.
66	12097371	Expression of CD94/NKG2 was maintained for at least 1 year following LCMV infection, as was the NKT cell marker.
67	12097371	By means of cell sorting and quantitative PCR, we found that NP118-specific CD8(+) T cells primarily express transcripts for inhibitory NKG2 receptor isoforms.
68	12097371	CD94/NKG2 expression was also observed on Ag-specific CD8(+) T cells following infection with polyoma virus, influenza virus, and Listeria monocytogenes, suggesting that it may be a common characteristic of Ag-specific CD8(+) T cells following infection with viral or bacterial pathogens.
69	12097371	Expression of CD94/NKG2 on memory-specific CD8(+) T cells did not change following secondary challenge with LCMV clone 13 and did not inhibit viral clearance.
70	12097371	Furthermore, we found no evidence that CD94/NKG2 inhibits either the lytic function of LCMV-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.
71	12097371	Finally, down-regulation of CD94/NKG2 was found to occur only during chronic LCMV infection.
72	12097371	Altogether, this study suggests that CD94/NKG2 expression is not necessarily correlated with inhibition of T cell function.
73	12874227	Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2.
74	12874227	The MHC class Ib molecule HLA-E is the primary ligand for CD94/NKG2A-inhibitory receptors expressed on NK cells, and there is also evidence for TCR-mediated recognition of this molecule.
75	12874227	Experiments with HLA-E tetramers bearing peptides substituted at nonanchor positions demonstrated that P5 and P8 are primary contact residues for interaction with CD94/NKG2 receptors.
76	12874227	A conservative replacement of Arg for Lys at P5 completely abrogated binding to CD94/NKG2.
77	12874227	Despite conservation of peptide-binding specificity in HLA-E and Qa-1, cross-species tetramer-staining experiments demonstrated that the interaction surfaces on CD94/NKG2 and the class Ib ligands have diverged between primates and rodents.
78	12874227	Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2.
79	12874227	The MHC class Ib molecule HLA-E is the primary ligand for CD94/NKG2A-inhibitory receptors expressed on NK cells, and there is also evidence for TCR-mediated recognition of this molecule.
80	12874227	Experiments with HLA-E tetramers bearing peptides substituted at nonanchor positions demonstrated that P5 and P8 are primary contact residues for interaction with CD94/NKG2 receptors.
81	12874227	A conservative replacement of Arg for Lys at P5 completely abrogated binding to CD94/NKG2.
82	12874227	Despite conservation of peptide-binding specificity in HLA-E and Qa-1, cross-species tetramer-staining experiments demonstrated that the interaction surfaces on CD94/NKG2 and the class Ib ligands have diverged between primates and rodents.
83	12874227	Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2.
84	12874227	The MHC class Ib molecule HLA-E is the primary ligand for CD94/NKG2A-inhibitory receptors expressed on NK cells, and there is also evidence for TCR-mediated recognition of this molecule.
85	12874227	Experiments with HLA-E tetramers bearing peptides substituted at nonanchor positions demonstrated that P5 and P8 are primary contact residues for interaction with CD94/NKG2 receptors.
86	12874227	A conservative replacement of Arg for Lys at P5 completely abrogated binding to CD94/NKG2.
87	12874227	Despite conservation of peptide-binding specificity in HLA-E and Qa-1, cross-species tetramer-staining experiments demonstrated that the interaction surfaces on CD94/NKG2 and the class Ib ligands have diverged between primates and rodents.
88	12874227	Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2.
89	12874227	The MHC class Ib molecule HLA-E is the primary ligand for CD94/NKG2A-inhibitory receptors expressed on NK cells, and there is also evidence for TCR-mediated recognition of this molecule.
90	12874227	Experiments with HLA-E tetramers bearing peptides substituted at nonanchor positions demonstrated that P5 and P8 are primary contact residues for interaction with CD94/NKG2 receptors.
91	12874227	A conservative replacement of Arg for Lys at P5 completely abrogated binding to CD94/NKG2.
92	12874227	Despite conservation of peptide-binding specificity in HLA-E and Qa-1, cross-species tetramer-staining experiments demonstrated that the interaction surfaces on CD94/NKG2 and the class Ib ligands have diverged between primates and rodents.
93	12874227	Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2.
94	12874227	The MHC class Ib molecule HLA-E is the primary ligand for CD94/NKG2A-inhibitory receptors expressed on NK cells, and there is also evidence for TCR-mediated recognition of this molecule.
95	12874227	Experiments with HLA-E tetramers bearing peptides substituted at nonanchor positions demonstrated that P5 and P8 are primary contact residues for interaction with CD94/NKG2 receptors.
96	12874227	A conservative replacement of Arg for Lys at P5 completely abrogated binding to CD94/NKG2.
97	12874227	Despite conservation of peptide-binding specificity in HLA-E and Qa-1, cross-species tetramer-staining experiments demonstrated that the interaction surfaces on CD94/NKG2 and the class Ib ligands have diverged between primates and rodents.
98	16275895	Bovine natural killer (NK) cells were recently identified by positive selection of a NK cell-activating receptor p46 (NKp46)+ CD3- lymphocyte population, which expresses CD25 and CD8 and lyses tumor cell lines following stimulation with recombinant interleukin-2.
99	16275895	In the current work, we characterize the cytotoxic/effector potential of a CD3(-)CD8(-)CD11b- population isolated through negative selection of bovine peripheral blood leukocytes.
100	16275895	This population is CD25(lo)CD62(hi) when isolated and becomes CD25hiCD62L(lo) following cytokine stimulation.
101	16275895	Activated bovine NK cells increase expression of granulysin, interferon-gamma, and perforin and have cytotoxic activity against human tumor cells and Mycobacterium bovis bacillus Calmette-Guerin-infected alveolar and monocyte-derived macrophages.
102	16275895	Expression of a bovine homologue of the CD56 neural adhesion molecule expressed by human NK cells was detected in mRNA from brain tissue but was not detected in peripheral blood mononuclear cells or purified NK cell mRNA.
103	16275895	Analysis of mRNA from nonstimulated peripheral blood NK cells demonstrates the constitutive expression of homologues of human NK receptors NKp46, CD244, and CD94 and the granule proteins granulysin and perforin.
104	16275895	Phorbol ester-stimulated CD8+ T cells also expressed CD244 and CD94, and CD4+ T cells expressed CD94.
105	16275895	Bovine natural killer (NK) cells were recently identified by positive selection of a NK cell-activating receptor p46 (NKp46)+ CD3- lymphocyte population, which expresses CD25 and CD8 and lyses tumor cell lines following stimulation with recombinant interleukin-2.
106	16275895	In the current work, we characterize the cytotoxic/effector potential of a CD3(-)CD8(-)CD11b- population isolated through negative selection of bovine peripheral blood leukocytes.
107	16275895	This population is CD25(lo)CD62(hi) when isolated and becomes CD25hiCD62L(lo) following cytokine stimulation.
108	16275895	Activated bovine NK cells increase expression of granulysin, interferon-gamma, and perforin and have cytotoxic activity against human tumor cells and Mycobacterium bovis bacillus Calmette-Guerin-infected alveolar and monocyte-derived macrophages.
109	16275895	Expression of a bovine homologue of the CD56 neural adhesion molecule expressed by human NK cells was detected in mRNA from brain tissue but was not detected in peripheral blood mononuclear cells or purified NK cell mRNA.
110	16275895	Analysis of mRNA from nonstimulated peripheral blood NK cells demonstrates the constitutive expression of homologues of human NK receptors NKp46, CD244, and CD94 and the granule proteins granulysin and perforin.
111	16275895	Phorbol ester-stimulated CD8+ T cells also expressed CD244 and CD94, and CD4+ T cells expressed CD94.
112	17462078	Differential induction of CD94 and NKG2 in CD4 helper T cells.
113	17462078	In this study we investigated CD94 and NKG2 gene expression in memory CD4 T-cell clones established from the spleens of C57BL/10 (H-2(b)) and BALB/c (H-2(d)) mice infected with influenza A virus (H3N2).
114	17462078	CD94 and NKG2A/C/E proteins form heterodimeric membrane receptors that are involved in virus recognition.
115	17462078	CD94 and NKG2 expression have been well characterized in natural killer (NK) and cytotoxic T cells.
116	17462078	Despite CD94 being potentially an important marker for Th1 cells involved in virus infection, however, there has been little investigation of its expression or function in the CD4 T-cell lineage and no studies have looked at in-vivo-generated Th cells or memory cells.
117	17462078	We show in this study that in-vivo-generated CD4 Th1 cells, but not Th2 cells, exhibited full-length CD94 and NKG2A gene expression following activation with viral peptide.
118	17462078	Another member of the NK receptor family, NKG2D, but not NKG2C or E, was also differentially expressed in Th1 cells.
119	17462078	We show here that CD94 and NKG2A may exist as multiple isoforms with the potential to distinguish helper T-cell subsets.
120	17462078	Differential induction of CD94 and NKG2 in CD4 helper T cells.
121	17462078	In this study we investigated CD94 and NKG2 gene expression in memory CD4 T-cell clones established from the spleens of C57BL/10 (H-2(b)) and BALB/c (H-2(d)) mice infected with influenza A virus (H3N2).
122	17462078	CD94 and NKG2A/C/E proteins form heterodimeric membrane receptors that are involved in virus recognition.
123	17462078	CD94 and NKG2 expression have been well characterized in natural killer (NK) and cytotoxic T cells.
124	17462078	Despite CD94 being potentially an important marker for Th1 cells involved in virus infection, however, there has been little investigation of its expression or function in the CD4 T-cell lineage and no studies have looked at in-vivo-generated Th cells or memory cells.
125	17462078	We show in this study that in-vivo-generated CD4 Th1 cells, but not Th2 cells, exhibited full-length CD94 and NKG2A gene expression following activation with viral peptide.
126	17462078	Another member of the NK receptor family, NKG2D, but not NKG2C or E, was also differentially expressed in Th1 cells.
127	17462078	We show here that CD94 and NKG2A may exist as multiple isoforms with the potential to distinguish helper T-cell subsets.
128	17462078	Differential induction of CD94 and NKG2 in CD4 helper T cells.
129	17462078	In this study we investigated CD94 and NKG2 gene expression in memory CD4 T-cell clones established from the spleens of C57BL/10 (H-2(b)) and BALB/c (H-2(d)) mice infected with influenza A virus (H3N2).
130	17462078	CD94 and NKG2A/C/E proteins form heterodimeric membrane receptors that are involved in virus recognition.
131	17462078	CD94 and NKG2 expression have been well characterized in natural killer (NK) and cytotoxic T cells.
132	17462078	Despite CD94 being potentially an important marker for Th1 cells involved in virus infection, however, there has been little investigation of its expression or function in the CD4 T-cell lineage and no studies have looked at in-vivo-generated Th cells or memory cells.
133	17462078	We show in this study that in-vivo-generated CD4 Th1 cells, but not Th2 cells, exhibited full-length CD94 and NKG2A gene expression following activation with viral peptide.
134	17462078	Another member of the NK receptor family, NKG2D, but not NKG2C or E, was also differentially expressed in Th1 cells.
135	17462078	We show here that CD94 and NKG2A may exist as multiple isoforms with the potential to distinguish helper T-cell subsets.
136	17462078	Differential induction of CD94 and NKG2 in CD4 helper T cells.
137	17462078	In this study we investigated CD94 and NKG2 gene expression in memory CD4 T-cell clones established from the spleens of C57BL/10 (H-2(b)) and BALB/c (H-2(d)) mice infected with influenza A virus (H3N2).
138	17462078	CD94 and NKG2A/C/E proteins form heterodimeric membrane receptors that are involved in virus recognition.
139	17462078	CD94 and NKG2 expression have been well characterized in natural killer (NK) and cytotoxic T cells.
140	17462078	Despite CD94 being potentially an important marker for Th1 cells involved in virus infection, however, there has been little investigation of its expression or function in the CD4 T-cell lineage and no studies have looked at in-vivo-generated Th cells or memory cells.
141	17462078	We show in this study that in-vivo-generated CD4 Th1 cells, but not Th2 cells, exhibited full-length CD94 and NKG2A gene expression following activation with viral peptide.
142	17462078	Another member of the NK receptor family, NKG2D, but not NKG2C or E, was also differentially expressed in Th1 cells.
143	17462078	We show here that CD94 and NKG2A may exist as multiple isoforms with the potential to distinguish helper T-cell subsets.
144	17462078	Differential induction of CD94 and NKG2 in CD4 helper T cells.
145	17462078	In this study we investigated CD94 and NKG2 gene expression in memory CD4 T-cell clones established from the spleens of C57BL/10 (H-2(b)) and BALB/c (H-2(d)) mice infected with influenza A virus (H3N2).
146	17462078	CD94 and NKG2A/C/E proteins form heterodimeric membrane receptors that are involved in virus recognition.
147	17462078	CD94 and NKG2 expression have been well characterized in natural killer (NK) and cytotoxic T cells.
148	17462078	Despite CD94 being potentially an important marker for Th1 cells involved in virus infection, however, there has been little investigation of its expression or function in the CD4 T-cell lineage and no studies have looked at in-vivo-generated Th cells or memory cells.
149	17462078	We show in this study that in-vivo-generated CD4 Th1 cells, but not Th2 cells, exhibited full-length CD94 and NKG2A gene expression following activation with viral peptide.
150	17462078	Another member of the NK receptor family, NKG2D, but not NKG2C or E, was also differentially expressed in Th1 cells.
151	17462078	We show here that CD94 and NKG2A may exist as multiple isoforms with the potential to distinguish helper T-cell subsets.
152	17462078	Differential induction of CD94 and NKG2 in CD4 helper T cells.
153	17462078	In this study we investigated CD94 and NKG2 gene expression in memory CD4 T-cell clones established from the spleens of C57BL/10 (H-2(b)) and BALB/c (H-2(d)) mice infected with influenza A virus (H3N2).
154	17462078	CD94 and NKG2A/C/E proteins form heterodimeric membrane receptors that are involved in virus recognition.
155	17462078	CD94 and NKG2 expression have been well characterized in natural killer (NK) and cytotoxic T cells.
156	17462078	Despite CD94 being potentially an important marker for Th1 cells involved in virus infection, however, there has been little investigation of its expression or function in the CD4 T-cell lineage and no studies have looked at in-vivo-generated Th cells or memory cells.
157	17462078	We show in this study that in-vivo-generated CD4 Th1 cells, but not Th2 cells, exhibited full-length CD94 and NKG2A gene expression following activation with viral peptide.
158	17462078	Another member of the NK receptor family, NKG2D, but not NKG2C or E, was also differentially expressed in Th1 cells.
159	17462078	We show here that CD94 and NKG2A may exist as multiple isoforms with the potential to distinguish helper T-cell subsets.
160	17462078	Differential induction of CD94 and NKG2 in CD4 helper T cells.
161	17462078	In this study we investigated CD94 and NKG2 gene expression in memory CD4 T-cell clones established from the spleens of C57BL/10 (H-2(b)) and BALB/c (H-2(d)) mice infected with influenza A virus (H3N2).
162	17462078	CD94 and NKG2A/C/E proteins form heterodimeric membrane receptors that are involved in virus recognition.
163	17462078	CD94 and NKG2 expression have been well characterized in natural killer (NK) and cytotoxic T cells.
164	17462078	Despite CD94 being potentially an important marker for Th1 cells involved in virus infection, however, there has been little investigation of its expression or function in the CD4 T-cell lineage and no studies have looked at in-vivo-generated Th cells or memory cells.
165	17462078	We show in this study that in-vivo-generated CD4 Th1 cells, but not Th2 cells, exhibited full-length CD94 and NKG2A gene expression following activation with viral peptide.
166	17462078	Another member of the NK receptor family, NKG2D, but not NKG2C or E, was also differentially expressed in Th1 cells.
167	17462078	We show here that CD94 and NKG2A may exist as multiple isoforms with the potential to distinguish helper T-cell subsets.
168	22735807	We have previously shown that vaccination with the natural tumor peptide Melan-A-induced T cells with superior effector functions as compared with vaccination with the analog peptide optimized for enhanced HLA-A*0201 binding.
169	22735807	Here we found that natural peptide vaccination induced tumor-reactive CD8 T cells with frequent coexpression of both memory/homing-associated genes (CD27, IL7R, EOMES, CXCR3, and CCR5) and effector-related genes (IFNG, KLRD1, PRF1, and GZMB), comparable with protective Epstein-Barr virus-specific and cytomegalovirus-specific T cells.
170	24530576	Our data suggests that stimulation with VACV triggers a cytotoxic response by NK cells marked by an increase of NCRs: NKp30, NKp44, and NKp46 in infected (vaccinated and unvaccinated) subjects and in non-infected vaccinated patients, when compared with non-infected unvaccinated individuals.
171	24530576	We demonstrated that stimulation with VACV downregulates the percentage of expression of Perforin, Granzyme A, and CD107a, but upregulate CD94 in infected (vaccinated and unvaccinated) subjects and in non-infected vaccinated patients, when compared with non-infected unvaccinated individuals.
172	24530576	Our data suggest that the expression of NCRs NKp30, NKp44, NKp46 and cytokines by NK cells are important in the innate response against VACV.