Ignet

Gene Information

Gene symbol: LEP

Gene name: leptin

HGNC ID: 6553

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	CD28	1 hits
3	CD4	1 hits
4	CRP	1 hits
5	CTLA4	1 hits
6	DPP4	1 hits
7	EPHB6	1 hits
8	FGF7	1 hits
9	GCG	1 hits
10	GHRL	1 hits
11	GZMB	1 hits
12	IGF1	1 hits
13	IL10	1 hits
14	IL1B	1 hits
15	IL2	1 hits
16	IL7	1 hits
17	INS	1 hits
18	LEPR	1 hits
19	MSTN	1 hits
20	PPARG	1 hits
21	PTPN1	1 hits
22	STAT3	1 hits
23	TGFB1	1 hits
24	TNF	1 hits
25	TRA	1 hits
26	TSLP	1 hits

Related Sentences

#	PMID	Sentence
1	3351484	The Pasteur strain used for the preparation of human rabies vaccine, the Flury high and low egg passage stains (HEP, LEP) used for animal vaccines, and the challenge virus standard (CVS) strain were also assayed.
2	4828510	Proceedings: Preliminary evaluation of pathogenic and immunogenic properties of the Flury LEP and HEP strains of rabies virus multiplied in chick embryo fibroblasts.
3	12042449	This study was designed to test whether breast-feeding attenuates reductions in energy intake associated with a mild immunologic stimulus and to assess poststimulus relationships among putative reductions in energy intake and serum interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and leptin concentrations.
4	12042449	Increases in leptin are associated with reductions in energy consumption in the postimmunization period in FF infants and postimmunization changes in IL-1beta concentrations likely are related to reductions in energy intake in response to immunologic stimuli.
5	12042449	This study was designed to test whether breast-feeding attenuates reductions in energy intake associated with a mild immunologic stimulus and to assess poststimulus relationships among putative reductions in energy intake and serum interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and leptin concentrations.
6	12042449	Increases in leptin are associated with reductions in energy consumption in the postimmunization period in FF infants and postimmunization changes in IL-1beta concentrations likely are related to reductions in energy intake in response to immunologic stimuli.
7	15080873	Insulin-like growth factor-1 (IGF-1) mediates many of the actions of GH, but has proved to be of more use as a growth reporter/selection marker in pigs, than as a viable treatment.
8	15080873	Leptin, adiponectin and myostatin were discovered through the study of genetically obese, or double-muscled animals.
9	15255186	Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice.
10	15255186	We assessed changes of the enzyme dipeptidyl peptidase IV (DPP IV, CD26) in the context of leptin or leptin receptor deficiency.
11	15255186	C57BL/6 mice, Leptin-deficient mice (ob/ob mice, B6.V-Lep<ob>) and Leptin-receptor-deficient mice (db/db mice, B6.Cg-m+/+Lepr) were infected with B.
12	15255186	The expression of DPP IV/CD26 on splenocytes was higher in ob/ob mice than in wild-type animals, and lower in db/db mice, and decreased upon stimulation with BCG in ob/ob mice only.
13	15255186	Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice.
14	15255186	We assessed changes of the enzyme dipeptidyl peptidase IV (DPP IV, CD26) in the context of leptin or leptin receptor deficiency.
15	15255186	C57BL/6 mice, Leptin-deficient mice (ob/ob mice, B6.V-Lep<ob>) and Leptin-receptor-deficient mice (db/db mice, B6.Cg-m+/+Lepr) were infected with B.
16	15255186	The expression of DPP IV/CD26 on splenocytes was higher in ob/ob mice than in wild-type animals, and lower in db/db mice, and decreased upon stimulation with BCG in ob/ob mice only.
17	16785512	In endotoxin-stressed mice, however, leptin prevented LPS-induced thymus weight loss and stimulated TCRalpha gene rearrangement.
18	17215847	It can be used to deliver protein drugs such as glucagon-like peptide 1 (GLP-1), leptin or transforming growth factor beta (TGF-beta).
19	20038483	IL-7 protects both B and T lymphocytes, but IL-2, IL-10, keratinocyte growth factor, thymic stromal lymphopoietin, as well as leptin and growth hormone also have a stimulatory effect on thymopoiesis.
20	22829612	At 130 d, serum leptin concentrations were similar in all groups, whereas IGF-I concentration was less in SC (P ≤ 0.002) than in the other groups.
21	22829612	Feed restriction had no effect on leptin or IGF-I concentrations in IC pigs.
22	22829612	At 130 d, serum leptin concentrations were similar in all groups, whereas IGF-I concentration was less in SC (P ≤ 0.002) than in the other groups.
23	22829612	Feed restriction had no effect on leptin or IGF-I concentrations in IC pigs.
24	23087691	Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection.
25	23087691	Our studies in this area have focused on gastric CD4(+) T(reg) in vaccinated mice, and raised the hypothesis that adipokines in particular leptin are involved the establishment of a protective gastric immune response.
26	23087691	Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection.
27	23087691	Our studies in this area have focused on gastric CD4(+) T(reg) in vaccinated mice, and raised the hypothesis that adipokines in particular leptin are involved the establishment of a protective gastric immune response.
28	24360890	We found a strong correlation between leptin concentration and BMI (r=0.55, p<0.0001), but no association with hemagglutination antibody inhibition (HAI), B-cell, or granzyme B responses.
29	24360890	We found eight SNPs in the LEP/LEPR/GHRL genes that were associated with leptin levels and four SNPs in the PTPN1/LEPR/STAT3 genes associated with peripheral blood TREC levels (p<0.05).
30	24360890	We also found eight SNPs in the LEP/PPARG/CRP genes associated with variations in influenza-specific HAI and B-cell responses (p<0.05).
31	24360890	We found a strong correlation between leptin concentration and BMI (r=0.55, p<0.0001), but no association with hemagglutination antibody inhibition (HAI), B-cell, or granzyme B responses.
32	24360890	We found eight SNPs in the LEP/LEPR/GHRL genes that were associated with leptin levels and four SNPs in the PTPN1/LEPR/STAT3 genes associated with peripheral blood TREC levels (p<0.05).
33	24360890	We also found eight SNPs in the LEP/PPARG/CRP genes associated with variations in influenza-specific HAI and B-cell responses (p<0.05).
34	24360890	We found a strong correlation between leptin concentration and BMI (r=0.55, p<0.0001), but no association with hemagglutination antibody inhibition (HAI), B-cell, or granzyme B responses.
35	24360890	We found eight SNPs in the LEP/LEPR/GHRL genes that were associated with leptin levels and four SNPs in the PTPN1/LEPR/STAT3 genes associated with peripheral blood TREC levels (p<0.05).
36	24360890	We also found eight SNPs in the LEP/PPARG/CRP genes associated with variations in influenza-specific HAI and B-cell responses (p<0.05).
37	24556090	Activated T cells show induced expression of, among other things, Glucose Transporter 1 and several glycolytic enzymes, including ADP-Dependent Glucokinase and the low affinity isoform Pyruvate Kinase-M2 (which promote glycolytic flux), as well Glutamine Transporters and Glycerol-3-phosphate Dehydrogenase 2 which make available glutamate and glycerol-3-phosphate as mitochondrial energy sources.
38	24556090	Unlike effector CD4(+) and CD8(+) T cells, Tregs and memory T cells oxidize fatty acids for fuel.
39	24556090	Upon activation, T cells express the insulin and leptin receptors on their surface and become sensitive to insulin signaling and nutrient availability and show changes in differentiation.