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Gene Information
Gene symbol: LGALS2
Gene name: lectin, galactoside-binding, soluble, 2
HGNC ID: 6562
Synonyms: HL14
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCND2 | 1 hits |
| 2 | LGALS1 | 1 hits |
| 3 | LGALS3 | 1 hits |
| 4 | LGALS9 | 1 hits |
| 5 | MUC1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15000151 | There are two structurally and functionally distinct classes of mucins: secreted gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC17), although the products of some MUC genes do not fit well into either class (MUC7, MUC8, MUC9, MUC13, MUC15, MUC16). |
| 2 | 15000151 | Expression of MUC2 secreted gel-forming mucin is generally decreased in colorectal adenocarcinoma, but preserved in mucinous carcinomas, a distinct subtype of colon cancer associated with microsatellite instability. |
| 3 | 15000151 | Another secreted gel-forming mucin, MUC5AC, a product of normal gastric mucosa, is absent from normal colon, but frequently present in colorectal adenomas and colon cancers. |
| 4 | 15000151 | The endogenous galactoside-binding protein galectin-3, which is expressed at higher levels in colon cancers than normal colon, binds to colon cancer mucin as well as other glycoproteins. |
| 5 | 15000151 | Interference of the binding of selectins and galectin-3 to mucin may show therapeutic or preventative promise for colon cancer. |
| 6 | 16310777 | Here, we show that galectin-3, a multifunctional beta-galactoside binding lectin present mainly in the cytoplasm of inflammatory cells and also present on the cell surface, can recognize mycobacterial mycolic acids. |
| 7 | 19155521 | Additionally, there was up-regulation of probesets associated with cytotoxic (GZMB, TNFSF10) and regulatory (INDO, CTLA4) activities. |
| 8 | 19155521 | The strongest correlations with neutralizing Ab titers were found for cyclin D2 (CCND2) and galectin (LGALS2). |
| 9 | 25760439 | In recent years, a critical role for β-galactoside-binding protein, Galectin-9 (Gal-9) has emerged in infectious disease, autoimmunity, and cancer. |
| 10 | 25760439 | It is a ligand for T cell immunoglobulin mucin domain 3 (Tim-3), a type-I glycoprotein that is persistently expressed on dysfunctional T cells during chronic viral infections. |
| 11 | 25760439 | Interaction of soluble Gal-9 with Tim-3 expressed on the surface of activated CD4+ T cells renders them less susceptible to HIV-1 infection, while enhanced HIV infection occurs when Gal-9 interacts with a different receptor than Tim-3. |
| 12 | 25556664 | The TFag has been shown to interact with Galectin-3 (Gal-3), one in a family of β-galactoside binding proteins. |
| 13 | 25556664 | Galectins have a variety of cellular functions, and Gal-3 has been shown to be the sole galectin with anti-apoptotic activity. |