Ignet

Gene Information

Gene symbol: LTB

Gene name: lymphotoxin beta (TNF superfamily, member 3)

HGNC ID: 6711

Synonyms: p33, TNFSF3

Related Genes

#	Gene Symbol	Number of hits
1	ALDH3A2	1 hits
2	ARHGEF2	1 hits
3	ATP6V0D1	1 hits
4	ATP6V1E1	1 hits
5	CCL2	1 hits
6	CCL5	1 hits
7	CD4	1 hits
8	CFB	1 hits
9	CLSTN2	1 hits
10	CORO1A	1 hits
11	CTBS	1 hits
12	CXCL1	1 hits
13	DCTN5	1 hits
14	GCY	1 hits
15	HSPA1A	1 hits
16	IFNG	1 hits
17	IL12A	1 hits
18	IL9	1 hits
19	LTA	1 hits
20	MYOZ3	1 hits
21	PSMC5	1 hits
22	SAFB	1 hits
23	SILV	1 hits
24	SLC22A7	1 hits
25	SULT1A3	1 hits
26	TP73	1 hits
27	UBASH3B	1 hits

Related Sentences

#	PMID	Sentence
1	2423607	Hepatitis B surface antigen (HBsAg) particles are composed of a major polypeptide, p25, and additional polypeptides of higher m.w., namely p33 and p39, are variably present.
2	7868230	Conversely, expression of an mRNA encoding the p40 subunit of IL-12 was not detected in control animals but was dramatically upregulated in immunized mice.
3	7868230	By using semiquantitative reverse transcription-PCR (RT-PCR) followed by competitive RT-PCR, differences in the magnitude of IL-12 p40 mRNA expression were quantified.
4	7868230	Six hours after oral immunization with the Salmonella construct, mice had 12.1- and 8.4-fold increases in expression of IL-12 p40 mRNA in the Peyer's patches and mesenteric lymph nodes, respectively, compared with control mice receiving only saline.
5	7868230	Oral immunization with LT-B alone also stimulated IL-12 p40 mRNA expression, but to a lesser extent.
6	7868230	The constitutive expression of IL-12 p35 mRNA at these mucosal sites coupled with a rapid and dramatic induction of IL-12 p40 mRNA following immunization with wild-type or attenuated strains of S. dublin is consistent with other investigations which support a role for IL-12 in modulating cell-mediated immune responses against intracellular pathogens.
7	9382733	Epitope analysis of the CS3 fimbrial subunit of human enterotoxigenic Escherichia coli and the construction of novel CS3::ST and CS3::LT-B immunogens.
8	10752686	However, since these molecules are toxic and cannot be used in human vaccines, it is important to study whether their non-toxic mucosa-binding B subunits, CTB and LTB, can be used as alternative safe mucosal adjuvants and/or carrier molecules.
9	10752686	We have as a model protein antigen used human gammaglobulin (HGG) for admixture with or chemical conjugation to recombinantly produced CTB and LTB, respectively, and measured antigen-specific local secretory IgA antibodies in saponin extracts from intestine and lung tissue by ELISA following intra-nasal (i.n.) or per-oral (p.o.) immunization.
10	10752686	However, since these molecules are toxic and cannot be used in human vaccines, it is important to study whether their non-toxic mucosa-binding B subunits, CTB and LTB, can be used as alternative safe mucosal adjuvants and/or carrier molecules.
11	10752686	We have as a model protein antigen used human gammaglobulin (HGG) for admixture with or chemical conjugation to recombinantly produced CTB and LTB, respectively, and measured antigen-specific local secretory IgA antibodies in saponin extracts from intestine and lung tissue by ELISA following intra-nasal (i.n.) or per-oral (p.o.) immunization.
12	11179323	These hybrid toxins were purified, and the composition and assembly of CT A subunit (CT-A)-LT B subunit (LT-B) and LT A subunit (LT-A)-CT B subunit (CT-B) were confirmed.
13	11179323	Specifically, LT-A-CT-B was able to augment the levels of antigen-specific gamma interferon (IFN-gamma) and interleukin 5 to levels comparable to those achieved with native LT, while CT-A-LT-B and native CT both produced lower levels of antigen-specific IFN-gamma.
14	11985274	The genetic determinants encoding CS3 and LT-B/ST fusion toxin were manipulated so that these important antigens are expressed simultaneously in attenuated Salmonella typhimurium oral vaccine strain X4072.
15	12496431	Previous studies have shown that nCT as mucosal adjuvant requires IL-4 and induces CD4-positive (CD4+) Th2-type responses, while nLT up-regulates Th1 cell production of IFN-gamma and IL-4-independent Th2-type responses.
16	12496431	To address the relative importance of the A or B subunits in CD4+ Th cell subset responses, chimeras of CT-A/LT-B and LT-A/CT-B were constructed.
17	12496431	Mice nasally immunized with CT-A/LT-B or LT-A/CT-B and the weak immunogen OVA developed OVA-specific, plasma IgG Abs titers similar to those induced by either nCT or nLT.
18	12496431	Both CT-A/LT-B and LT-A/CT-B promoted secretory IgA anti-OVA Ab, which established their retention of mucosal adjuvant activity.
19	12496431	The CT-A/LT-B chimera, like nLT, induced OVA-specific mucosal and peripheral CD4+ T cells secreting IFN-gamma and IL-4-independent Th2-type responses, with plasma IgG2a anti-OVA Abs.
20	12496431	Further, LT-A/CT-B, like nCT, promoted plasma IgG1 more than IgG2a and IgE Abs with OVA-specific CD4+ Th2 cells secreting high levels of IL-4, but not IFN-gamma.
21	12496431	The LT-A/CT-B chimera and nCT, but not the CT-A/LT-B chimera or nLT, suppressed IL-12R expression and IFN-gamma production by activated T cells.
22	12496431	Previous studies have shown that nCT as mucosal adjuvant requires IL-4 and induces CD4-positive (CD4+) Th2-type responses, while nLT up-regulates Th1 cell production of IFN-gamma and IL-4-independent Th2-type responses.
23	12496431	To address the relative importance of the A or B subunits in CD4+ Th cell subset responses, chimeras of CT-A/LT-B and LT-A/CT-B were constructed.
24	12496431	Mice nasally immunized with CT-A/LT-B or LT-A/CT-B and the weak immunogen OVA developed OVA-specific, plasma IgG Abs titers similar to those induced by either nCT or nLT.
25	12496431	Both CT-A/LT-B and LT-A/CT-B promoted secretory IgA anti-OVA Ab, which established their retention of mucosal adjuvant activity.
26	12496431	The CT-A/LT-B chimera, like nLT, induced OVA-specific mucosal and peripheral CD4+ T cells secreting IFN-gamma and IL-4-independent Th2-type responses, with plasma IgG2a anti-OVA Abs.
27	12496431	Further, LT-A/CT-B, like nCT, promoted plasma IgG1 more than IgG2a and IgE Abs with OVA-specific CD4+ Th2 cells secreting high levels of IL-4, but not IFN-gamma.
28	12496431	The LT-A/CT-B chimera and nCT, but not the CT-A/LT-B chimera or nLT, suppressed IL-12R expression and IFN-gamma production by activated T cells.
29	12496431	Previous studies have shown that nCT as mucosal adjuvant requires IL-4 and induces CD4-positive (CD4+) Th2-type responses, while nLT up-regulates Th1 cell production of IFN-gamma and IL-4-independent Th2-type responses.
30	12496431	To address the relative importance of the A or B subunits in CD4+ Th cell subset responses, chimeras of CT-A/LT-B and LT-A/CT-B were constructed.
31	12496431	Mice nasally immunized with CT-A/LT-B or LT-A/CT-B and the weak immunogen OVA developed OVA-specific, plasma IgG Abs titers similar to those induced by either nCT or nLT.
32	12496431	Both CT-A/LT-B and LT-A/CT-B promoted secretory IgA anti-OVA Ab, which established their retention of mucosal adjuvant activity.
33	12496431	The CT-A/LT-B chimera, like nLT, induced OVA-specific mucosal and peripheral CD4+ T cells secreting IFN-gamma and IL-4-independent Th2-type responses, with plasma IgG2a anti-OVA Abs.
34	12496431	Further, LT-A/CT-B, like nCT, promoted plasma IgG1 more than IgG2a and IgE Abs with OVA-specific CD4+ Th2 cells secreting high levels of IL-4, but not IFN-gamma.
35	12496431	The LT-A/CT-B chimera and nCT, but not the CT-A/LT-B chimera or nLT, suppressed IL-12R expression and IFN-gamma production by activated T cells.
36	15618162	Serum antibodies generated against LTB and CfaB demonstrated antitoxin and agglutination activities, respectively.
37	15618162	These results suggest that CfaB and LTB expressed in SC608 retain important conformational epitopes that are required for the generation of antibodies that have functional activities.
38	15618162	Serum antibodies generated against LTB and CfaB demonstrated antitoxin and agglutination activities, respectively.
39	15618162	These results suggest that CfaB and LTB expressed in SC608 retain important conformational epitopes that are required for the generation of antibodies that have functional activities.
40	15948247	Construction of a novel Shigella live-vector strain co-expressing CS3 and LTB/STm of enterotoxigenic E.coli.
41	16157421	We have shown that FITC-labeled nLT is taken up by human dendritic cells (hDC) in vitro and in mouse skin, and induces maturation and activation of hDC in vitro. hDC matured with nLT enhanced nonspecific melanoma antigen uptake and presentation to autologous CD8+ T cells.
42	16157421	In mouse in vivo studies, nLT or LTB were applied on the skin either mixed with recombinant gp100 or genetically fused with a multiepitope polypeptide (MEP).
43	16426008	Eight M. suis-specific antigens (p33, p40, p45, p57, p61, p70, p73, and p83) were identified as targets of the immunoglobulin G (IgG) antibody response during experimental infection, with p40, p45, and p70 being the preferentially recognized M. suis antigens.
44	18198938	In contrast with maize-expressed LTB, the DT50 for bacterially produced LTB and CTB was less than 4 d both in pond water and soil.
45	19050273	Our results demonstrate that protection of wild-type mice immunized with cell-free Ags from H. capsulatum against histoplasmosis was associated with increased LTB(4) and IFN-gamma production as well as recruitment of memory T cells into the lungs.
46	19269688	On the other hand, the role of their non-toxic B-subunits, CTB or LTB, in enhancing mucosal immune response is not clear.
47	19443238	Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti.
48	19443238	In this study, we investigated the immunological effects of bovine heat shock protein 70 (HSP70) on the major Theileria sergenti surface protein (p33).
49	19443238	The gene encoding p33 was expressed as a fusion protein with bovine HSP70 from a plasmid vector.
50	19443238	The adjuvant function of HSP70 on p33 was evaluated with regard to antibody response, cytokine production, and a challenge experiment in mice or cattle.
51	19443238	The HSP adjuvant activity toward p33 was also possible to detect in the inoculated cattle.
52	19443238	Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti.
53	19443238	In this study, we investigated the immunological effects of bovine heat shock protein 70 (HSP70) on the major Theileria sergenti surface protein (p33).
54	19443238	The gene encoding p33 was expressed as a fusion protein with bovine HSP70 from a plasmid vector.
55	19443238	The adjuvant function of HSP70 on p33 was evaluated with regard to antibody response, cytokine production, and a challenge experiment in mice or cattle.
56	19443238	The HSP adjuvant activity toward p33 was also possible to detect in the inoculated cattle.
57	19443238	Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti.
58	19443238	In this study, we investigated the immunological effects of bovine heat shock protein 70 (HSP70) on the major Theileria sergenti surface protein (p33).
59	19443238	The gene encoding p33 was expressed as a fusion protein with bovine HSP70 from a plasmid vector.
60	19443238	The adjuvant function of HSP70 on p33 was evaluated with regard to antibody response, cytokine production, and a challenge experiment in mice or cattle.
61	19443238	The HSP adjuvant activity toward p33 was also possible to detect in the inoculated cattle.
62	19443238	Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti.
63	19443238	In this study, we investigated the immunological effects of bovine heat shock protein 70 (HSP70) on the major Theileria sergenti surface protein (p33).
64	19443238	The gene encoding p33 was expressed as a fusion protein with bovine HSP70 from a plasmid vector.
65	19443238	The adjuvant function of HSP70 on p33 was evaluated with regard to antibody response, cytokine production, and a challenge experiment in mice or cattle.
66	19443238	The HSP adjuvant activity toward p33 was also possible to detect in the inoculated cattle.
67	19443238	Adjuvant effect of bovine heat shock protein 70 on piroplasm surface protein, p33, of Theileria sergenti.
68	19443238	In this study, we investigated the immunological effects of bovine heat shock protein 70 (HSP70) on the major Theileria sergenti surface protein (p33).
69	19443238	The gene encoding p33 was expressed as a fusion protein with bovine HSP70 from a plasmid vector.
70	19443238	The adjuvant function of HSP70 on p33 was evaluated with regard to antibody response, cytokine production, and a challenge experiment in mice or cattle.
71	19443238	The HSP adjuvant activity toward p33 was also possible to detect in the inoculated cattle.
72	21085949	Protection of mice against enterotoxigenic E. coli by immunization with a polyvalent enterotoxin comprising a combination of LTB, STa, and STb.
73	21085949	In this study, we genetically constructed a trivalent enterotoxin fusion protein (STa-LTB-STb, abbreviated to SLS) in an effort to develop a single toxoid containing these three enterotoxins for vaccination against ETEC.
74	21085949	Mutagenesis at one disulfide-bridge-forming cysteine in STa led to a dramatic reduction in the STa toxicity of SLS; however, the fusion peptide retained the STb-associated toxicity.
75	21085949	Immunization of mice with SLS protein elicited significant antibody responses to LTB, STa, and STb.
76	21085949	Protection of mice against enterotoxigenic E. coli by immunization with a polyvalent enterotoxin comprising a combination of LTB, STa, and STb.
77	21085949	In this study, we genetically constructed a trivalent enterotoxin fusion protein (STa-LTB-STb, abbreviated to SLS) in an effort to develop a single toxoid containing these three enterotoxins for vaccination against ETEC.
78	21085949	Mutagenesis at one disulfide-bridge-forming cysteine in STa led to a dramatic reduction in the STa toxicity of SLS; however, the fusion peptide retained the STb-associated toxicity.
79	21085949	Immunization of mice with SLS protein elicited significant antibody responses to LTB, STa, and STb.
80	21994354	The development of such strains has culminated in the testing of a three-strain-combination live attenuated vaccine known as ACE527, comprised of strains ACAM2025 expressing colonization factor antigen I (CFA/I) and LTB; ACAM2022, expressing CS5, CS6, and LTB; and ACAM2027, expressing CS1, CS2, CS3, and LTB.
81	21994354	Similarly, strong immune responses to LTB and to CFs expressed on all three constituent strains were induced, with at least 50% of subjects in the high-dose group responding to LTB, CFA/I, CS3, and CS6.
82	21994354	The development of such strains has culminated in the testing of a three-strain-combination live attenuated vaccine known as ACE527, comprised of strains ACAM2025 expressing colonization factor antigen I (CFA/I) and LTB; ACAM2022, expressing CS5, CS6, and LTB; and ACAM2027, expressing CS1, CS2, CS3, and LTB.
83	21994354	Similarly, strong immune responses to LTB and to CFs expressed on all three constituent strains were induced, with at least 50% of subjects in the high-dose group responding to LTB, CFA/I, CS3, and CS6.
84	22009111	The appropriate size of the LTB(4)/CFAgs-loaded MS (smaller than 10μm) enabled the efficient uptake by BMDM and also induced TNF-α, CXCL1/KC, CCL2/MCP-1, CCL5/RANTES and nitrite oxide release by these cells.
85	22053005	The expression of CfaB and LTB in BI was verified by electrophoretic analysis.
86	22053005	These results suggest that expressing CfaB and LTB in BI provides a probiotic system with immunogenic properties.
87	22053005	The expression of CfaB and LTB in BI was verified by electrophoretic analysis.
88	22053005	These results suggest that expressing CfaB and LTB in BI provides a probiotic system with immunogenic properties.
89	22727726	Japanese herbal medicines may be excellent adjuvants for oral Lactobacillus-based vaccines and oral immunization of LacE7, HET and LTB may have the potential to elicit extremely high E7-specific mucosal cytotoxic immune response to HPV-associated neoplastic lesions.
90	23306362	Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein.
91	25203447	We have recently identified the two major determinants of the glycoprotein G of the viral hemorrhagic septicaemia rhabdovirus (gpGVHSV), peptides p31 and p33 implicated in triggering the host type I IFN antiviral response associated to these rhabdoviral antigens.
92	25203447	In addition, a plasmid construct encoding both sequences p31 and p33 (pMCV1.4-p31+p33) was also designed.
93	25203447	We have recently identified the two major determinants of the glycoprotein G of the viral hemorrhagic septicaemia rhabdovirus (gpGVHSV), peptides p31 and p33 implicated in triggering the host type I IFN antiviral response associated to these rhabdoviral antigens.
94	25203447	In addition, a plasmid construct encoding both sequences p31 and p33 (pMCV1.4-p31+p33) was also designed.
95	26305793	Taken together, these data support the inclusion of both LT-A and LT-B in prospective vaccines against ETEC.