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Gene Information

Gene symbol: MAA

Gene name: microphthalmia or anophthalmia and associated anomalies

HGNC ID: 6755

Related Genes

#	Gene Symbol	Number of hits
1	AIRE	1 hits
2	ANKRD36B	1 hits
3	CD4	1 hits
4	CD8A	1 hits
5	HLA-A	1 hits
6	MAPK1	1 hits
7	MLANA	1 hits
8	SILV	1 hits
9	TRNAP2	1 hits

Related Sentences

#	PMID	Sentence
1	8811494	Analysis of expression of the melanoma-associated antigens MART-1 and gp100 in metastatic melanoma cell lines and in in situ lesions.
2	8811494	MART-1 and gp100 melanoma associated antigens (MAA) are expressed by cells of the melanocytic lineage and are recognized by the majority of HLA-A2 restricted tumor-infiltrating lymphocytes.
3	8811494	One cell line did not express MART-1 or gp100.
4	8811494	None of the nonmelanoma cancer lines tested stained for MART-1 or gp100.
5	8811494	Analysis of melanoma lesions by immunohistochemistry showed significant heterogeneity of expression of both MART-1 and gp100 MAA either as a percentage of cells expressing MAA or as intensity of expression.
6	9220317	In 6/6 HLA A*0201-expressing melanoma patients tested, the virally driven expression of MART-1/Melan A MAA by DC was sufficient to generate CD8+ T lymphocytes that could recognize naturally processed epitopes on tumor cells.
7	11863419	We developed a polyvalent melanoma gene vaccine using a plasmid vector to deliver the immunogenic human melanoma-associated antigens (MAAs) gp100 and TRP-2.
8	11863419	Although both i.m. and i.n. immunization induced Th1 (T helper) and Th2 cell responses to gp100 and TRP2, the i.m. route induced a better Th1 response.
9	12944117	Six of these loci were found to differ between MAA and MAP in the number of tandem repeat motifs occurring at each MIRU locus.
10	14502218	The aim of the present study is to demonstrate the predominance of ex vivo genetic DC manipulation using AdRGD in improving the efficacy of DC-based immunotherapy targeting gp100, a melanoma-associated antigen (MAA).
11	14502218	Furthermore, in vivo depletion analysis demonstrated that CD8(+) CTLs and NK cells were the predominant effector cells responsible for the anti-B16BL6 immunity induced by vaccination with AdRGD-gp100/mBM-DCs, and that helper function of CD4(+) T cells was necessary for sufficiently eliciting effector activity.
12	21375556	While tolerance to MAA in the CD8(+) T cell compartment is well characterized, it is still not the case for the CD4(+) T cell compartment.
13	21375556	In total, our study demonstrates the existence of low avidity MAA-specific CD4(+) T cells escaping by ignorance central and peripheral tolerance, but valuable in the context of vaccination against melanoma.
14	22506061	Similarly, the enlarged T cell repertoire in AIRE(-/-) mice enables them to mount anti-MAA and anti-melanoma responses as shown by increased anti-melanoma antibodies, and enhanced CD4(+) and MAA-specific CD8(+) T cell responses after melanoma challenge.
15	22506061	We show that thymic expression of gp100 is under the control of AIRE, leading to increased gp100-specific CD8(+) T cell frequencies in AIRE(-/-) mice.
16	22506061	TRP-2 (tyrosinase-related protein), on the other hand, is absent from TECs and consequently TRP-2 specific CD8(+) T cells were found in both AIRE(-/-) and AIRE(+/+) mice.