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Gene Information
Gene symbol: MAGIX
Gene name: MAGI family member, X-linked
HGNC ID: 30006
Synonyms: PDZX, JM10, FLJ21687
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BAK1 | 1 hits |
| 2 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26234678 | E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60. |
| 2 | 26234678 | Tat-interacting protein of 60 kDa (TIP60) is an essential lysine acetyltransferase implicated in transcription, DNA damage response and apoptosis. |
| 3 | 26234678 | In cervical cancers, human papillomavirus (HPV) E6 oncogene targets cellular p53, Bak and some of the PDZ domain-containing proteins for proteasome-mediated degradation through E6AP ligase. |
| 4 | 26234678 | Our proteomic analyses revealed EDD1 (E3 identified by differential display), an E3 ligase generally overexpressed in cancers as a novel interacting partner of TIP60. |
| 5 | 26234678 | Strikingly, HPV E6 uses this function of EDD1 to destabilize TIP60. |
| 6 | 26234678 | Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro. |