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Gene Information
Gene symbol: MAP2K1
Gene name: mitogen-activated protein kinase kinase 1
HGNC ID: 6840
Synonyms: MEK1, MAPKK1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CAMP | 1 hits |
| 2 | MAPK1 | 1 hits |
| 3 | MAPK14 | 1 hits |
| 4 | MAPK3 | 1 hits |
| 5 | PIK3CA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16972797 | HABP cleaves kininogen in vitro, releasing the vasoactive peptide bradykinin, and activates plasminogen activators, suggesting a vascular cell-directed physiological function of this novel plasma protease. |
| 2 | 16972797 | On the one hand, HABP releases bradykinin from cell surface-bound or soluble kininogen and triggers a bradykinin B2-receptor-dependent mobilisation of intracellular Ca2+. |
| 3 | 16972797 | On the other hand, HABP activates the p44/42-dependent MAPK (ERK1/2) signalling cascade independent of the B2-receptor, but involving the fibroblast growth factor receptor-1 and basic fibroblast growth factor. |
| 4 | 16972797 | This signalling pathway leads to phosphorylation of the kinases Raf, MEK1/2 and ERK1/2. |
| 5 | 16972797 | The extracellular activity of HABP also affects the gene expression level through phosphorylation of two transcription factors, the cAMP-responsive element binding protein CREB and the proto-oncogene c-Myc. |
| 6 | 18579695 | Finally, inhibition of the MEK1/2 and p38 mitogen-activated protein kinase (MAPK) signaling pathways reduced M. bovis BCG-mediated LL-37 mRNA expression, a reduction that correlated with the observed high level of downregulation of LL-37 protein induction. |
| 7 | 18579695 | Thus, these results indicate that the MEK1/2 and p38 MAPK signaling pathways play a critical role in the regulation of inducible LL-37 gene expression in A549 cells infected with M. bovis BCG. |
| 8 | 18579695 | Finally, inhibition of the MEK1/2 and p38 mitogen-activated protein kinase (MAPK) signaling pathways reduced M. bovis BCG-mediated LL-37 mRNA expression, a reduction that correlated with the observed high level of downregulation of LL-37 protein induction. |
| 9 | 18579695 | Thus, these results indicate that the MEK1/2 and p38 MAPK signaling pathways play a critical role in the regulation of inducible LL-37 gene expression in A549 cells infected with M. bovis BCG. |
| 10 | 22722749 | PI3K- and Akt-specific inhibitors abrogated IDR-1002-induced adhesion and activation of β(1)-integrins, whereas p38 and MEK1 inhibitors did not affect, or moderately inhibited, adhesion, respectively. |
| 11 | 25241249 | Pharmacological inhibition of MEK1/2 through U0126 treatment of VERO cells blockades not only the YFV-stimulated ERK1/2 phosphorylation, but also inhibits YFV replication by ∼99%. |