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Gene Information
Gene symbol: MAP2K3
Gene name: mitogen-activated protein kinase kinase 3
HGNC ID: 6843
Synonyms: MEK3, MKK3, MAPKK3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDC2 | 1 hits |
| 2 | FOXM1 | 1 hits |
| 3 | MAPK1 | 1 hits |
| 4 | PLK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20023695 | The Ras oncogene is known to activate three major MAPK pathways, ERK, JNK, p38 and exert distinct cellular phenotypes, that is, apoptosis and invasion through the Ras-MKK3-p38-signaling cascade. |
| 2 | 20023695 | Stable transfection of NIH3T3 fibroblasts with MKK3(act) cDNA construct revealed similar p38-dependent in vitro characteristics observed in Ha-Ras(EJ)-transformed NIH3T3 cells, including enhanced invasiveness and anchorage-independent growth correlating with p38 phosphorylation status. |
| 3 | 20023695 | Using this phenotype-assisted approach combined with system level protein-interaction network analysis, we identified FOXM1, PLK1 and CDK1 to be differentially regulated in invasive Ha-Ras(EJ)-NIH3T3 and MKK3(act)-NIH3T3 cells. |
| 4 | 20023695 | The Ras oncogene is known to activate three major MAPK pathways, ERK, JNK, p38 and exert distinct cellular phenotypes, that is, apoptosis and invasion through the Ras-MKK3-p38-signaling cascade. |
| 5 | 20023695 | Stable transfection of NIH3T3 fibroblasts with MKK3(act) cDNA construct revealed similar p38-dependent in vitro characteristics observed in Ha-Ras(EJ)-transformed NIH3T3 cells, including enhanced invasiveness and anchorage-independent growth correlating with p38 phosphorylation status. |
| 6 | 20023695 | Using this phenotype-assisted approach combined with system level protein-interaction network analysis, we identified FOXM1, PLK1 and CDK1 to be differentially regulated in invasive Ha-Ras(EJ)-NIH3T3 and MKK3(act)-NIH3T3 cells. |
| 7 | 20937847 | The regulation of Th1 responses by the p38 MAPK. |
| 8 | 20937847 | IL-12 production was also increased in macrophages treated with small interfering RNA to limit p38α expression, and in macrophages deficient in MKK3, a kinase upstream of p38. |
| 9 | 20937847 | The increase in IL-12 production following MAPK/p38 inhibition appears to be due to enhanced IL-12 (p40) mRNA stability. |