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Gene Information
Gene symbol: MAPK4
Gene name: mitogen-activated protein kinase 4
HGNC ID: 6878
Synonyms: Erk3-related, Erk4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MAP3K5 | 1 hits |
| 2 | MAPK3 | 1 hits |
| 3 | MAPK8 | 1 hits |
| 4 | MAPK9 | 1 hits |
| 5 | TNFRSF9 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15181282 | CD137 (4-1BB), is an inducible T-cell costimulatory receptor and a member of the tumor necrosis factor receptor (TNFR) superfamily. |
| 2 | 15181282 | The natural counter receptor for CD137 is 4-1BB ligand, a member of the TNF superfamily that is weakly expressed on naïve or resting B cells, macrophages, and DCs. |
| 3 | 15181282 | In T cells CD137-induced signals lead to the recruitment of TRAF family members and activation of several kinases, including ASK-1, MKK, MAPK3/ MAPK4, p38, and JNK/SAPK. |
| 4 | 15181282 | Kinase activation is then followed by the activation and nuclear translocation of several transcription factors, including ATF-2, Jun, and NF-kappaB. |
| 5 | 15181282 | In addition to augmenting suboptimal TCR-induced proliferation, CD137-mediated signaling protects T cells, and in particular, CD8+ T cells from activation-induced cell death (AICD). |