Ignet

Gene Information

Gene symbol: MARCH1

Gene name: membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase

HGNC ID: 26077

Synonyms: FLJ20668, MARCH-I, RNF171

Related Genes

#	Gene Symbol	Number of hits
1	HLA-A	1 hits
2	IL10	1 hits
3	RNF123	1 hits
4	TLR3	1 hits
5	TOLLIP	1 hits

Related Sentences

#	PMID	Sentence
1	24384074	An in vitro model of antigen presentation showed that ligands for TLR-9, 7, 4 and 1/2 increased the ability of APCs to present antigen-85B of BCG to CD4 T cells, which correlated with an increase in MHC-II expression.
2	24384074	TLR-activation led to a down-regulation of MARCH1 ubiquitin ligase which prevents the degradation of MHC-II and decreased IL-10 also contributed to an increase in MHC-II.
3	24384074	TLR-activation induced up-regulation of MHC-II was inhibited by the blockade of IRAK, NF-kB, and MAPKs.
4	24384074	TLR-7 and TLR-9 ligands had the most effective adjuvant like effect on MHC-II of APCs which allowed BCG vaccine mediated activation of CD4 T cells.
5	24600555	Here, we have addressed the effect of Tollip and MARCH1 on the regulation of MHC II trafficking and TLR signaling.
6	24600555	Our results show that MARCH1-deficient mice splenocytes are impaired in their capacity to produce pro-inflammatory cytokines in response to poly(I:C) and that TLR3 and MHC II molecules interact in the endocytic pathway.
7	24600555	Knocking down Tollip expression in human CIITA(+) HeLa cells increased expression of HLA-DR but reduced the proportion of MHC II molecules associated with the CLIP peptide.
8	24600555	While overexpression of Tollip did not affect HLA-DR levels, it antagonized the function of co-transfected MARCH1.
9	24600555	We found that Tollip strongly reduced MARCH1 protein levels and that the two molecules appear to compete for binding to MHC II molecules.
10	24600555	Altogether, our results demonstrate that Tollip regulates MHC class II trafficking and that MARCH1 may represent a new Tollip target.
11	24600555	Here, we have addressed the effect of Tollip and MARCH1 on the regulation of MHC II trafficking and TLR signaling.
12	24600555	Our results show that MARCH1-deficient mice splenocytes are impaired in their capacity to produce pro-inflammatory cytokines in response to poly(I:C) and that TLR3 and MHC II molecules interact in the endocytic pathway.
13	24600555	Knocking down Tollip expression in human CIITA(+) HeLa cells increased expression of HLA-DR but reduced the proportion of MHC II molecules associated with the CLIP peptide.
14	24600555	While overexpression of Tollip did not affect HLA-DR levels, it antagonized the function of co-transfected MARCH1.
15	24600555	We found that Tollip strongly reduced MARCH1 protein levels and that the two molecules appear to compete for binding to MHC II molecules.
16	24600555	Altogether, our results demonstrate that Tollip regulates MHC class II trafficking and that MARCH1 may represent a new Tollip target.
17	24600555	Here, we have addressed the effect of Tollip and MARCH1 on the regulation of MHC II trafficking and TLR signaling.
18	24600555	Our results show that MARCH1-deficient mice splenocytes are impaired in their capacity to produce pro-inflammatory cytokines in response to poly(I:C) and that TLR3 and MHC II molecules interact in the endocytic pathway.
19	24600555	Knocking down Tollip expression in human CIITA(+) HeLa cells increased expression of HLA-DR but reduced the proportion of MHC II molecules associated with the CLIP peptide.
20	24600555	While overexpression of Tollip did not affect HLA-DR levels, it antagonized the function of co-transfected MARCH1.
21	24600555	We found that Tollip strongly reduced MARCH1 protein levels and that the two molecules appear to compete for binding to MHC II molecules.
22	24600555	Altogether, our results demonstrate that Tollip regulates MHC class II trafficking and that MARCH1 may represent a new Tollip target.
23	24600555	Here, we have addressed the effect of Tollip and MARCH1 on the regulation of MHC II trafficking and TLR signaling.
24	24600555	Our results show that MARCH1-deficient mice splenocytes are impaired in their capacity to produce pro-inflammatory cytokines in response to poly(I:C) and that TLR3 and MHC II molecules interact in the endocytic pathway.
25	24600555	Knocking down Tollip expression in human CIITA(+) HeLa cells increased expression of HLA-DR but reduced the proportion of MHC II molecules associated with the CLIP peptide.
26	24600555	While overexpression of Tollip did not affect HLA-DR levels, it antagonized the function of co-transfected MARCH1.
27	24600555	We found that Tollip strongly reduced MARCH1 protein levels and that the two molecules appear to compete for binding to MHC II molecules.
28	24600555	Altogether, our results demonstrate that Tollip regulates MHC class II trafficking and that MARCH1 may represent a new Tollip target.
29	24600555	Here, we have addressed the effect of Tollip and MARCH1 on the regulation of MHC II trafficking and TLR signaling.
30	24600555	Our results show that MARCH1-deficient mice splenocytes are impaired in their capacity to produce pro-inflammatory cytokines in response to poly(I:C) and that TLR3 and MHC II molecules interact in the endocytic pathway.
31	24600555	Knocking down Tollip expression in human CIITA(+) HeLa cells increased expression of HLA-DR but reduced the proportion of MHC II molecules associated with the CLIP peptide.
32	24600555	While overexpression of Tollip did not affect HLA-DR levels, it antagonized the function of co-transfected MARCH1.
33	24600555	We found that Tollip strongly reduced MARCH1 protein levels and that the two molecules appear to compete for binding to MHC II molecules.
34	24600555	Altogether, our results demonstrate that Tollip regulates MHC class II trafficking and that MARCH1 may represent a new Tollip target.