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PMID |
Sentence |
1 |
14722266
|
Poxviruses and gamma-2 herpesviruses share the K3 family of viral immune evasion proteins that inhibit the surface expression of glycoproteins such as major histocompatibility complex class I (MHC-I), B7.2, ICAM-1, and CD95(Fas).
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2 |
14722266
|
K3 family proteins contain an amino-terminal PHD/LAP or RING-CH domain followed by two transmembrane domains.
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3 |
14722266
|
Two closely related proteins, MARCH-IV and MARCH-IX, reduced surface expression of MHC-I molecules.
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4 |
14722266
|
In the presence of MARCH-IV or MARCH-IX, MHC-I was ubiquitinated and rapidly internalized by endocytosis, whereas MHC-I molecules lacking lysines in their cytoplasmic tail were resistant to downregulation.
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5 |
14722266
|
Poxviruses and gamma-2 herpesviruses share the K3 family of viral immune evasion proteins that inhibit the surface expression of glycoproteins such as major histocompatibility complex class I (MHC-I), B7.2, ICAM-1, and CD95(Fas).
|
6 |
14722266
|
K3 family proteins contain an amino-terminal PHD/LAP or RING-CH domain followed by two transmembrane domains.
|
7 |
14722266
|
Two closely related proteins, MARCH-IV and MARCH-IX, reduced surface expression of MHC-I molecules.
|
8 |
14722266
|
In the presence of MARCH-IV or MARCH-IX, MHC-I was ubiquitinated and rapidly internalized by endocytosis, whereas MHC-I molecules lacking lysines in their cytoplasmic tail were resistant to downregulation.
|