Ignet

Gene Information

Gene symbol: MIRN221

Gene name: microRNA 221

HGNC ID: 31601

Related Genes

#	Gene Symbol	Number of hits
1	BCL2L11	1 hits
2	CDKN1C	1 hits
3	IFNG	1 hits
4	IL6	1 hits
5	MARCH8	1 hits
6	NFKB1	1 hits
7	SOCS1	1 hits
8	STAT1	1 hits
9	STAT3	1 hits

Related Sentences

#	PMID	Sentence
1	23845179	IL4 and IFNalpha generation of dendritic cells reveals great migratory potential and NFkB and cJun expression in IL4DCs.
2	23845179	Dendritic cells (DCs) recently revealed as a potent tumor vaccine component, are commonly differentiated from monocytes by cultivation with IL-4 and GM-CSF.
3	23845179	The aim of this study was to compare the functionality and phenotypic characterization of monocyte-derived DC generated by IL-4 (IL4DC) and IFNalpha (IFNalphaDC) modified protocols.
4	23845179	We herein investigated the molecular mechanism underlying the parameters previously described, as the relative expression of NF-kB p65, c-fos and c-jun, transcription factors.
5	23845179	Our results demonstrated that IL4DC presented a stable phenotype, an increase in migratory capacity and NF-KB activation, in addition to lower levels of miR-146 a and miR-221.
6	26090579	IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment.
7	26090579	We report that IFN-α downregulates miR-221 in both DC subsets via inhibition of STAT3.
8	26090579	We validated proapoptotic proteins BCL2L11 and CDKN1C as miR-221 targets suggesting that IFN-α can induce DC apoptosis via miR-221 downregulation.
9	26090579	In addition, we validated another miR-221 target, SOCS1, which is known to be a negative regulator of JAK/STAT signaling.
10	26090579	Consistent with this, miR-221 overexpression in mDCs enhanced the secretion of proinflammatory cytokines IL-6 and TNF-α.
11	26090579	In peripheral blood mononuclear cells (PBMCs) of HIV-1/HCV co-infected individuals undergoing IFN-α-based treatment the baseline miR-221 expression was lower in non-responders compared with responders; and miR-221 expression directly correlated with DC frequency and IL-6/TNF-α secretion.
12	26090579	IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment.
13	26090579	We report that IFN-α downregulates miR-221 in both DC subsets via inhibition of STAT3.
14	26090579	We validated proapoptotic proteins BCL2L11 and CDKN1C as miR-221 targets suggesting that IFN-α can induce DC apoptosis via miR-221 downregulation.
15	26090579	In addition, we validated another miR-221 target, SOCS1, which is known to be a negative regulator of JAK/STAT signaling.
16	26090579	Consistent with this, miR-221 overexpression in mDCs enhanced the secretion of proinflammatory cytokines IL-6 and TNF-α.
17	26090579	In peripheral blood mononuclear cells (PBMCs) of HIV-1/HCV co-infected individuals undergoing IFN-α-based treatment the baseline miR-221 expression was lower in non-responders compared with responders; and miR-221 expression directly correlated with DC frequency and IL-6/TNF-α secretion.
18	26090579	IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment.
19	26090579	We report that IFN-α downregulates miR-221 in both DC subsets via inhibition of STAT3.
20	26090579	We validated proapoptotic proteins BCL2L11 and CDKN1C as miR-221 targets suggesting that IFN-α can induce DC apoptosis via miR-221 downregulation.
21	26090579	In addition, we validated another miR-221 target, SOCS1, which is known to be a negative regulator of JAK/STAT signaling.
22	26090579	Consistent with this, miR-221 overexpression in mDCs enhanced the secretion of proinflammatory cytokines IL-6 and TNF-α.
23	26090579	In peripheral blood mononuclear cells (PBMCs) of HIV-1/HCV co-infected individuals undergoing IFN-α-based treatment the baseline miR-221 expression was lower in non-responders compared with responders; and miR-221 expression directly correlated with DC frequency and IL-6/TNF-α secretion.
24	26090579	IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment.
25	26090579	We report that IFN-α downregulates miR-221 in both DC subsets via inhibition of STAT3.
26	26090579	We validated proapoptotic proteins BCL2L11 and CDKN1C as miR-221 targets suggesting that IFN-α can induce DC apoptosis via miR-221 downregulation.
27	26090579	In addition, we validated another miR-221 target, SOCS1, which is known to be a negative regulator of JAK/STAT signaling.
28	26090579	Consistent with this, miR-221 overexpression in mDCs enhanced the secretion of proinflammatory cytokines IL-6 and TNF-α.
29	26090579	In peripheral blood mononuclear cells (PBMCs) of HIV-1/HCV co-infected individuals undergoing IFN-α-based treatment the baseline miR-221 expression was lower in non-responders compared with responders; and miR-221 expression directly correlated with DC frequency and IL-6/TNF-α secretion.
30	26090579	IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment.
31	26090579	We report that IFN-α downregulates miR-221 in both DC subsets via inhibition of STAT3.
32	26090579	We validated proapoptotic proteins BCL2L11 and CDKN1C as miR-221 targets suggesting that IFN-α can induce DC apoptosis via miR-221 downregulation.
33	26090579	In addition, we validated another miR-221 target, SOCS1, which is known to be a negative regulator of JAK/STAT signaling.
34	26090579	Consistent with this, miR-221 overexpression in mDCs enhanced the secretion of proinflammatory cytokines IL-6 and TNF-α.
35	26090579	In peripheral blood mononuclear cells (PBMCs) of HIV-1/HCV co-infected individuals undergoing IFN-α-based treatment the baseline miR-221 expression was lower in non-responders compared with responders; and miR-221 expression directly correlated with DC frequency and IL-6/TNF-α secretion.
36	26090579	IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment.
37	26090579	We report that IFN-α downregulates miR-221 in both DC subsets via inhibition of STAT3.
38	26090579	We validated proapoptotic proteins BCL2L11 and CDKN1C as miR-221 targets suggesting that IFN-α can induce DC apoptosis via miR-221 downregulation.
39	26090579	In addition, we validated another miR-221 target, SOCS1, which is known to be a negative regulator of JAK/STAT signaling.
40	26090579	Consistent with this, miR-221 overexpression in mDCs enhanced the secretion of proinflammatory cytokines IL-6 and TNF-α.
41	26090579	In peripheral blood mononuclear cells (PBMCs) of HIV-1/HCV co-infected individuals undergoing IFN-α-based treatment the baseline miR-221 expression was lower in non-responders compared with responders; and miR-221 expression directly correlated with DC frequency and IL-6/TNF-α secretion.