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Gene Information
Gene symbol: MPL
Gene name: myeloproliferative leukemia virus oncogene
HGNC ID: 7217
Synonyms: CD110, TPOR
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CD8A | 1 hits |
| 3 | GFPT1 | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | IL2 | 1 hits |
| 6 | MUC1 | 1 hits |
| 7 | MYD88 | 1 hits |
| 8 | PDB1 | 1 hits |
| 9 | TICAM1 | 1 hits |
| 10 | TLR4 | 1 hits |
| 11 | VWS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8882734 | Immunization with PC, PS-liposomes containing unconjugated Gfpt1 and MPL stimulated the highest titers observed, thereby effectively preventing tumor growth in Balbc nu/nu-mice challenged with human small cell lung cancer cells. |
| 2 | 11553536 | Mice immunized with PdB in MPL plus AlPO4 were also significantly better protected than mice that received PdB in AlPO4 alone. |
| 3 | 11566599 | LPS, MPL, CpG DNA, which activate cells of the innate immune system. |
| 4 | 12455401 | LPS, MPL, CpG DNA, which activate cells of the innate immune system. |
| 5 | 12782048 | LPS, MPL and CpG DNA, which activate cells of the innate immune system. |
| 6 | 15046255 | LPS, MPL, CpG DNA, which activate cells of the innate immune system. |
| 7 | 17032239 | We found the ratio of IgG2b/IgG1 and the secretion of interferon (IFN)-gamma in the mice vaccinated with the new protein with adjuvant MPL and TDM were higher than the mice immunized with fusion protein Ag85B-ESAT-6, which have been reported and could induce levels of protective immunity similar to BCG in the mouse model of tuberculosis (TB) infection. |
| 8 | 21449154 | The first is composed of viral-like particles of HPV 16, 18 and a complex of two adjuvants (aluminum salts and MPL [TLR-4 agonist]). |
| 9 | 23297218 | Whereas wild-type Escherichia coli LPS provokes strong inflammatory MyD88 (myeloid differentiation primary response gene 88)-mediated TLR4 signaling, MPL preferentially induces less inflammatory TRIF (TIR-domain-containing adaptor-inducing IFN-β)-mediated responses. |
| 10 | 24378623 | The data suggested that DDA/MPL-adjuvant MUC-1 VPP vaccine may be developed into effective tumor vaccines for melanomas and possibly for other tumors expressing MUC1 protein. |
| 11 | 24877765 | CAF09 was superior in its ability to induce antigen-specific CD8+ T cells as compared to other previously described CTL-inducing adjuvants, CAF05 (DDA/trehalose dibehenate (TDB)/Poly(I:C)), Aluminium/monophosphoryl lipid-A (MPL) and Montanide/CpG/IL-2. |
| 12 | 24877765 | The CD4+ T cells induced by CAF09 were mainly of an effector-memory-like phenotype and the CD8+ T cells were highly cytotoxic. |
| 13 | 24951867 | A mechanistic study provides evidence that activation of dendritic cells by the toll-like receptor 4 agonist MPL in the AS04 adjuvant was associated with interferon-γ producing CD4 T cell responses. |