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Gene Information
Gene symbol: MT2A
Gene name: metallothionein 2A
HGNC ID: 7406
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CDKN1A | 1 hits |
| 3 | MT1A | 1 hits |
| 4 | MT3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8349820 | Sera obtained prior to boosting had undetectable HIV-1-specific IgG and neutralizing activity, and did not block HIV-1 from binding or fusing to CD4+ MT-2 cells. 14 d after boosting, sera from each volunteer contained HIV-1-specific IgG titers of 1:40 to 1:1,280. |
| 2 | 14520699 | Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2. |
| 3 | 14520699 | Tax transfection resulted in enhanced expression of p21 protein in T and fibroblastoid cells. |
| 4 | 14520699 | Similarly, Tax-expressing cells have higher amounts of endogenous p21 protein and RNA. |
| 5 | 14520699 | However, neither Tax-negative, HTLV-1 transformed cells or HTLV-1-negative T cell lines had detectable levels of p21 protein and RNA. |
| 6 | 14520699 | CREB/ATF defective Tax mutant (M47) activated the p21 promoter significantly less efficiently. |
| 7 | 14520699 | Tax activated wild type (wt) p21 promoter in p53-negative Jurkat and p53-positive A301cells, irrespective of endogenous p53 status, and activated a mutant p21 promoter containing a p53 responsive element (p53RE) deletion as strongly as wt promoter. |
| 8 | 14520699 | Of importance, cdk2 activity was almost completely abolished in Tax-induced p21-expressing MT-2 cells, suggesting that Tax-induced p21 predominantly affects the activity of cdk2, a late G1 and S phase kinase. |
| 9 | 14520699 | Taken together, these findings suggest that HTLV-1 Tax activates p21/Waf1/Cip1, a cell growth inhibitor, in a p53-independent mechanism through CREB/ATF-related transcription factors, and inhibits cdk2. |
| 10 | 19357975 | MT-1 and MT-3 mRNAs were expressed in the cerebellum in a dose-dependent manner. |
| 11 | 19357975 | In the cerebrum, little MT-1 protein was detected at 10 and 24 h, and there were no peaks of MT-2 protein in the cerebrum. |
| 12 | 19357975 | In conclusion, MT-1 and MT-3 mRNAs but not MT-2 mRNA are easily expressed in the cerebellum rather than in the cerebrum by the injection of low-dose thimerosal. |
| 13 | 19357975 | MT-1 and MT-3 mRNAs were expressed in the cerebellum in a dose-dependent manner. |
| 14 | 19357975 | In the cerebrum, little MT-1 protein was detected at 10 and 24 h, and there were no peaks of MT-2 protein in the cerebrum. |
| 15 | 19357975 | In conclusion, MT-1 and MT-3 mRNAs but not MT-2 mRNA are easily expressed in the cerebellum rather than in the cerebrum by the injection of low-dose thimerosal. |