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Gene Information
Gene symbol: MTA1
Gene name: metastasis associated 1
HGNC ID: 7410
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL6 | 1 hits |
| 2 | MTA3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26460037 | Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3. |
| 2 | 26460037 | Mimicked acetylation of the Bcl6 middle domain (K379Q) in CD4 T cells results in significant reductions in Tfh differentiation in vivo. |
| 3 | 26460037 | Although Bcl6 K379Q still bound to the Prdm1 cis-regulatory elements in Tfh cells, Prdm1 expression was derepressed. |
| 4 | 26460037 | This was a result of the failure of Bcl6 K379Q to recruit metastasis-associated protein 3 (MTA3). |
| 5 | 26460037 | The loss of Bcl6 function in Bcl6 K379Q-expressing CD4 T cells could be partially rescued by abrogating Prdm1 expression. |
| 6 | 26460037 | In addition to Prdm1, we found that Bcl6 recruits MTA3 to multiple genes involved in Tfh cell biology, including genes important for cell migration, cell survival, and alternative differentiation pathways. |
| 7 | 26460037 | Thus, Bcl6 middle domain mediated repression is a major mechanism of action by which Bcl6 controls CD4 T-cell fate and function. |