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Gene Information
Gene symbol: MUC3B
Gene name: mucin 3B, cell surface associated
HGNC ID: 13384
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
15000151
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There are two structurally and functionally distinct classes of mucins: secreted gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC17), although the products of some MUC genes do not fit well into either class (MUC7, MUC8, MUC9, MUC13, MUC15, MUC16).
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2 |
15000151
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Expression of MUC2 secreted gel-forming mucin is generally decreased in colorectal adenocarcinoma, but preserved in mucinous carcinomas, a distinct subtype of colon cancer associated with microsatellite instability.
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3 |
15000151
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Another secreted gel-forming mucin, MUC5AC, a product of normal gastric mucosa, is absent from normal colon, but frequently present in colorectal adenomas and colon cancers.
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4 |
15000151
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The endogenous galactoside-binding protein galectin-3, which is expressed at higher levels in colon cancers than normal colon, binds to colon cancer mucin as well as other glycoproteins.
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5 |
15000151
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Interference of the binding of selectins and galectin-3 to mucin may show therapeutic or preventative promise for colon cancer.
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6 |
23827311
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Interaction of this protozoan parasite with the intestine is mediated through the binding of the trophozoite stage to intestinal mucin and epithelium via a galactose and N-acetyl-d-galactosamine (Gal/GalNAc) lectin comprised of a disulfide linked heavy (ca. 180 kDa) and light chain (ca. 35 kDa) and a noncovalently bound intermediate subunit (ca. 150 kDa).
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7 |
24478066
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EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin.
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