Ignet

Gene Information

Gene symbol: MUC5AC

Gene name: mucin 5AC, oligomeric mucus/gel-forming

HGNC ID: 7515

Synonyms: MUC5

Related Genes

#	Gene Symbol	Number of hits
1	CGB	1 hits
2	ERBB2	1 hits
3	FOLH1	1 hits
4	HLA-A	1 hits
5	IL1B	1 hits
6	IL8	1 hits
7	MAPK1	1 hits
8	MAPK14	1 hits
9	MUC1	1 hits
10	MUC12	1 hits
11	MUC13	1 hits
12	MUC15	1 hits
13	MUC16	1 hits
14	MUC17	1 hits
15	MUC2	1 hits
16	MUC3A	1 hits
17	MUC3B	1 hits
18	MUC4	1 hits
19	MUC5B	1 hits
20	MUC6	1 hits
21	MUC7	1 hits
22	MUC8	1 hits
23	NFKB1	1 hits
24	STN	1 hits
25	TACSTD1	1 hits
26	TLR2	1 hits
27	TNF	1 hits
28	VCAN	1 hits

Related Sentences

#	PMID	Sentence
1	396619	Mice were challenged intraperitoneally with P haemolytica in gastric mucin, and viable counts were performed 6 h later on liver suspensions.
2	523808	Mice were inoculated intraperitoneally with P haemolytica incorporated in gastric mucin, killed at various time intervals thereafter and viable counts of bacteria were performed on liver suspensions.
3	925044	Comparative antigenicity testing of cholera vaccines by application of hog gastric mucin and ferric ammonium citrate.
4	993220	An investigation of alternatives to hog gastric mucin as virulence-enhancing agents in the cholera vaccine potency assay.
5	1262061	The cells were suspended in 5% hog gastric mucin.
6	1311488	This strain is attenuated in mice when given by the intraperitoneal route suspended in hog gastric mucin and is attenuated to a similar level to strains harbouring deletions in aroA or aroC alone indicating that both lesions are capable of attenuating independently.
7	1759503	Using intraperitoneal inoculation of mice with S. typhi strains suspended in hog gastric mucin as a virulence assay, it is shown that the single aro mutants and the double aro mutants of Ty2 and ISP1820 are attenuated in mice.
8	6175648	A comparative study of gastric mucin and commercial baker's yeast as virulence-enhancing agents in the typhoid mouse protection test.
9	9387291	The molecular structure of mucin core peptide (apomucin) was identified recently.
10	9387291	To further elucidate the role of apomucin in the modulation of cancers, this study was to investigate the immune responses induced by mucin core peptide in mice.
11	9387291	When mice immunized with this apomucin (10 micrograms/time x 6) plus DETOX, all mice developed delayed-type hypersensitivity (DTH) after challanged with apomucin or synthetic mucin core peptide MUC-2 or MUC-3, while the mice immunized with only apomucin did not develop DTH.
12	9387291	The cytotoxicity could be blocked by antibodies against MUC-2 and MUC-3.
13	9387291	The molecular structure of mucin core peptide (apomucin) was identified recently.
14	9387291	To further elucidate the role of apomucin in the modulation of cancers, this study was to investigate the immune responses induced by mucin core peptide in mice.
15	9387291	When mice immunized with this apomucin (10 micrograms/time x 6) plus DETOX, all mice developed delayed-type hypersensitivity (DTH) after challanged with apomucin or synthetic mucin core peptide MUC-2 or MUC-3, while the mice immunized with only apomucin did not develop DTH.
16	9387291	The cytotoxicity could be blocked by antibodies against MUC-2 and MUC-3.
17	9387291	The molecular structure of mucin core peptide (apomucin) was identified recently.
18	9387291	To further elucidate the role of apomucin in the modulation of cancers, this study was to investigate the immune responses induced by mucin core peptide in mice.
19	9387291	When mice immunized with this apomucin (10 micrograms/time x 6) plus DETOX, all mice developed delayed-type hypersensitivity (DTH) after challanged with apomucin or synthetic mucin core peptide MUC-2 or MUC-3, while the mice immunized with only apomucin did not develop DTH.
20	9387291	The cytotoxicity could be blocked by antibodies against MUC-2 and MUC-3.
21	9516914	In this study, the distribution of the tumor-associated antigens GM2, Tn, sTn, Thompson-Friedenreich antigen (TF), Globo H, Le(y), MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC7, carcinoembryonic antigen, beta chain of human chorionic gonadotropin (hCG beta), HER2/neu, PSMA, and KSA on primary and metastatic prostate cancer and 16 types of normal tissues was compared by immunohistochemistry, using a panel of well-characterized monoclonal antibodies.
22	9516914	Our results show that GM2, KSA, and MUC2 were strongly expressed on 8 or 9 of 9 metastatic prostate cancer biopsy specimens and, with PSMA, hCG beta, TF, Tn, and sTn, on 8 or more of 11 primary prostate cancer specimens.
23	9516914	Tn, MUC1, and PSMA were expressed on 4-6 of 9 metastatic specimens.
24	9516914	Tn, sTn, hCG beta, and MUC2 were detected on up to 3 of 10 types of normal epithelia.
25	9516914	GM2, TF, MUC1, and KSA were more broadly distributed on normal epithelia, all primarily at the secretory borders.
26	9516914	STn, KSA, and hCG beta were also detected in the testis, and GM2 was expressed on gray matter of brain.
27	9516914	From the 30 antigens that we have screened, this study provides the basis for selecting GM2, TF, Tn, sTn, hCG beta, MUC1, MUC2, KSA, and PSMA as target antigens for specific immunotherapy of prostate cancer.
28	10608618	Seventeen human ovarian carcinoma cell lines were evaluated for their expression of mucin core polypeptide mRNAs (MUC1, MUC2, MUC3, MUC5AC, MUC5B, and MUC6) by the reverse transcription-polymerase chain reaction.
29	10608618	Mucin-associated carbohydrate epitopes were not detected on three of four serous adenocarcinoma cell lines, although MUC1 and MUC2 mRNAs were detected in all of them.
30	11102566	Frequently in tumors of the pancreas there are changes in the structure of mucin carbohydrates and/or levels of apomucin types.
31	11447145	In mice inoculated intraperitoneally with serovar Typhi and hog gastric mucin (to estimate the relative degree of attenuation), the 50% lethal dose of CVD 915 (7.7 x 10(7) CFU) was significantly higher than that of wild-type Ty2 (1.4 x 10(2) CFU) and was only slightly lower than that of Ty21a (1.9 x 10(8) CFU).
32	12686724	Among those signaling pathways, activation of NF-kappaB leads to up-regulation of IL-1beta, IL-8 and TNF-alpha, mucin MUC2 and Toll-like receptor 2 (TLR2), whereas activation of p38 MAP kinase mediates not only up-regulation of inflammatory mediators and mucin MUC5AC but also down-regulation of TLR2.
33	12686724	Interestingly, NTHi-induced activation of the PI3K-Akt pathway, however, leads to inhibition of p38 mitogen-activated protein (MAP) kinase.
34	12686724	Moreover, the TGF-beta-Smad signaling pathway cooperates with NF-kappaB to mediate up-regulation of mucin MUC2.
35	12686724	Finally, glucocorticoids synergistically enhance NTHi-induced TLR2 expression via specific up-regulation of the MAP kinase phosphatase-1 that, in turn, leads to inactivation of p38 MAP kinase, the negative regulator for TLR2 expression.
36	15000151	There are two structurally and functionally distinct classes of mucins: secreted gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC17), although the products of some MUC genes do not fit well into either class (MUC7, MUC8, MUC9, MUC13, MUC15, MUC16).
37	15000151	Expression of MUC2 secreted gel-forming mucin is generally decreased in colorectal adenocarcinoma, but preserved in mucinous carcinomas, a distinct subtype of colon cancer associated with microsatellite instability.
38	15000151	Another secreted gel-forming mucin, MUC5AC, a product of normal gastric mucosa, is absent from normal colon, but frequently present in colorectal adenomas and colon cancers.
39	15000151	The endogenous galactoside-binding protein galectin-3, which is expressed at higher levels in colon cancers than normal colon, binds to colon cancer mucin as well as other glycoproteins.
40	15000151	Interference of the binding of selectins and galectin-3 to mucin may show therapeutic or preventative promise for colon cancer.
41	15000151	There are two structurally and functionally distinct classes of mucins: secreted gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC17), although the products of some MUC genes do not fit well into either class (MUC7, MUC8, MUC9, MUC13, MUC15, MUC16).
42	15000151	Expression of MUC2 secreted gel-forming mucin is generally decreased in colorectal adenocarcinoma, but preserved in mucinous carcinomas, a distinct subtype of colon cancer associated with microsatellite instability.
43	15000151	Another secreted gel-forming mucin, MUC5AC, a product of normal gastric mucosa, is absent from normal colon, but frequently present in colorectal adenomas and colon cancers.
44	15000151	The endogenous galactoside-binding protein galectin-3, which is expressed at higher levels in colon cancers than normal colon, binds to colon cancer mucin as well as other glycoproteins.
45	15000151	Interference of the binding of selectins and galectin-3 to mucin may show therapeutic or preventative promise for colon cancer.
46	17403868	In an in vitro assay, antisera to either the native or the recombinant CD inhibited the binding activity of CD to human tracheobronchial mucin in a serum concentration-dependent manner, and the extent of inhibition appeared to correlate with the corresponding anti-CD antibody titer and whole-cell enzyme-linked immunosorbent assay titer.
47	21241407	Strain-dependent proliferation in response to human gastric mucin and adhesion properties of Helicobacter pylori are not affected by co-isolated Lactobacillus sp.
48	21697763	Identification of HLA-A0201- and A2402-restricted epitopes of mucin 5AC expressed in advanced pancreatic cancer.
49	25210718	The present work probes the interactions between Lactococcus lactis and mucins using pig gastric mucin (PGM) as a model.
50	26267898	One VHH specific for GI.1 and three specific for GII.4 could block the binding of homologous VLPs to synthetic HBGA carbohydrates, saliva, and pig gastric mucin, and in addition, could inhibit the hemagglutination of red blood cells by homologous VLPs.