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Gene Information
Gene symbol: NCF2
Gene name: neutrophil cytosolic factor 2
HGNC ID: 7661
Synonyms: p67phox, NOXA2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CIDX | 1 hits |
| 3 | CYBA | 1 hits |
| 4 | CYBB | 1 hits |
| 5 | IFNG | 1 hits |
| 6 | MTA2 | 1 hits |
| 7 | NCF1 | 1 hits |
| 8 | NOX5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8807512 | Their diagnoses were: chemotaxis defect, cellular immunodeficiency, combined immunodeficiency and chronic granulomatous disease (CGD). |
| 2 | 10790422 | We also show that HP-NAP is chemotactic for human leukocytes and that it activates their NADPH oxidase to produce reactive oxygen intermediates, as demonstrated by the translocation of its cytosolic subunits to the plasma membrane, and by the lack of activity on chronic granulomatous disease leukocytes. |
| 3 | 10790422 | This stimulating effect is strongly potentiated by tumor necrosis factor alpha and interferon gamma and is mediated by a rapid increase of the cytosolic calcium concentration. |
| 4 | 16908516 | Confocal microscopy demonstrated that NADPH oxidase assembly was disrupted, and LVS phagosomes did not acquire gp91/p22(phox) or p47/p67(phox). |
| 5 | 18078106 | Among these 39 cases, 13 had been diagnosed to have some types of primary immunodeficiency (5 cases: chronic granulomatous disease (CGD); 4 cases: severe combined immunodeficiency (SCID); 4 cases: IFN-gamma receptor 1 deficiency). |
| 6 | 18762975 | Disseminated Bacillus Calmette-Guérin lymphadenitis in a patient with gp91phox- chronic granulomatous disease 25 years after vaccination. |
| 7 | 22523066 | CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease. |
| 8 | 22523066 | Both CD4(+) and CD8(+) T cells mediate vaccine-induced protection from experimental aspergillosis, but the molecular mechanisms leading to the generation of protective immunity and whether these mechanisms are dysregulated in individuals with CGD have not been determined. |
| 9 | 22523066 | Aspergillus conidia activated CD8(+) T cells upon sorting to the Rab14(+) endosomal compartment required for alternative MHC class I presentation. |
| 10 | 22523066 | Our study thus indicates that distinct intracellular pathways are exploited for the priming of CD4(+) and CD8(+) T cells to A. fumigatus and suggests that CD4(+) T cell vaccination may be able to overcome defective antifungal CD8(+) T cell memory in individuals with CGD. |
| 11 | 24722620 | Thirty-two patients (43.2%) had definitive primary immunodeficiency diseases (PID) and chronic granulomatous disease (CGD) is the most common PID (n = 23, accounted for 71.9% of all PID patients). |
| 12 | 24916152 | Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections. |
| 13 | 24916152 | Genetic deficiency in the reactive oxygen species (ROS)-producing phagocyte NADPH oxidase NOX2 is called chronic granulomatous disease (CGD). |
| 14 | 24916152 | Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections. |
| 15 | 24916152 | Genetic deficiency in the reactive oxygen species (ROS)-producing phagocyte NADPH oxidase NOX2 is called chronic granulomatous disease (CGD). |