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Gene Information
Gene symbol: NLRP1
Gene name: NLR family, pyrin domain containing 1
HGNC ID: 14374
Synonyms: KIAA0926, DKFZp586O1822, CARD7, NAC, CLR17.1, DEFCAP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP1 | 1 hits |
| 2 | IL1B | 1 hits |
| 3 | NLRC4 | 1 hits |
| 4 | NLRP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25786687 | Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling. |
| 2 | 25786687 | CT, mmCT, and dmLT strongly enhanced IL-17A and to a lesser extent IL-13 responses, but had little effect on IFN-γ production or cell proliferation. |
| 3 | 25786687 | Intracellular cytokine staining revealed that the enhanced IL-17A production was largely confined to CD4(+) T cells and coculture experiments showed that the IL-17A promotion was effectively induced by adjuvant-treated monocytes. |
| 4 | 25786687 | Thus, inhibition of cAMP-dependent protein kinase A was abolished, and stimulation with a cAMP analog mimicked the adjuvant effect. |
| 5 | 25786687 | Furthermore, CT, mmCT, and dmLT induced IL-1β production and caspase-1 activation in monocytes, which was associated with increased expression of key proinflammatory and inflammasome-related genes, including NLRP1, NLRP3, and NLRC4. |
| 6 | 25786687 | Inflammasome inhibition with a specific caspase-1 inhibitor, or blocking of IL-1 signaling by IL-1 receptor antagonist, abrogated the Th17-promoting effect. |
| 7 | 25786687 | We conclude that CT, mmCT, and dmLT promote human Th17 responses via cAMP-dependent protein kinase A and caspase-1/inflammasome-dependent IL-1 signaling. |