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Gene Information
Gene symbol: OAS1
Gene name: 2'-5'-oligoadenylate synthetase 1, 40/46kDa
HGNC ID: 8086
Synonyms: OIASI, IFI-4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DDX58 | 1 hits |
| 2 | EIF2AK2 | 1 hits |
| 3 | IFIH1 | 1 hits |
| 4 | IL2 | 1 hits |
| 5 | LGALS3 | 1 hits |
| 6 | MRC1 | 1 hits |
| 7 | OAS2 | 1 hits |
| 8 | OAS3 | 1 hits |
| 9 | PTX3 | 1 hits |
| 10 | TLR2 | 1 hits |
| 11 | TLR4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20079393 | We identified 23 significant associations (p < 0.05) between polymorphisms within the 2'-5'-oligoadenylate synthetase (OAS) gene cluster, and rubella virus-specific IL-2, IL-10, IL-6 secretion, and antibody levels. |
| 2 | 20079393 | The minor allele variants of three OAS1 SNPs (rs3741981/Ser162Gly, rs1051042/Thr361Arg, rs2660), located in a linkage disequilibrium block of functional importance, were significantly associated with an increase in rubella virus-specific IL-2/T(h)1 response (p <or = 0.024). |
| 3 | 20079393 | Seven OAS1 and OAS3 promoter/regulatory SNPs were similarly associated with IL-2 secretion. |
| 4 | 20079393 | We identified 23 significant associations (p < 0.05) between polymorphisms within the 2'-5'-oligoadenylate synthetase (OAS) gene cluster, and rubella virus-specific IL-2, IL-10, IL-6 secretion, and antibody levels. |
| 5 | 20079393 | The minor allele variants of three OAS1 SNPs (rs3741981/Ser162Gly, rs1051042/Thr361Arg, rs2660), located in a linkage disequilibrium block of functional importance, were significantly associated with an increase in rubella virus-specific IL-2/T(h)1 response (p <or = 0.024). |
| 6 | 20079393 | Seven OAS1 and OAS3 promoter/regulatory SNPs were similarly associated with IL-2 secretion. |
| 7 | 22426325 | At the injection site, 594 genes were differentially expressed, including up-regulation of the cytokines osteopontin (SPP1), IL-10 and IL-18 and the chemokines CCL2, CCL19 and CXCL16. |
| 8 | 22426325 | Of the 362 genes differentially expressed in the lymph node, IL-1β and CXCL11 were up-regulated whereas IL18, CCL15 and CXCL12 were down-regulated. |
| 9 | 22426325 | ISCOM-Matrix also modulated genes for pattern recognition receptors at the injection site (TLR2, TLR4, MRC1, PTX3, LGALS3) and in the lymph node (TLR4, RIG-I, MDA5, OAS1, EIF2AK2, LGALS3). |
| 10 | 25752600 | Analysis of positively selected sites in OAS1, OAS2, and MB21D1 revealed parallel evolution, with the corresponding residues being selected in different genes. |