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Gene Information
Gene symbol: PACS2
Gene name: phosphofurin acidic cluster sorting protein 2
HGNC ID: 23794
Synonyms: KIAA0602
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PECAM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16601245 | In endothelial cells (ECs), K5 additionally reduced expression of CD31/platelet-endothelial cell adhesion molecule (PECAM), an adhesion molecule regulating cell-cell interactions of ECs, platelets, monocytes, and T cells. |
| 2 | 16601245 | In the endoplasmic reticulum, newly synthesized CD31 was degraded by proteasomes, which required binding of phosphofurin acidic cluster sorting protein-2 (PACS-2) to acidic residues in the carboxyterminal tail of K5. |
| 3 | 16601245 | Thus, CD31, a novel target of K5, is efficiently removed from ECs by a dual degradation mechanism that is regulated by the subcellular sorting of the ubiquitin ligase. |