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Gene Information
Gene symbol: PARK2
Gene name: parkinson protein 2, E3 ubiquitin protein ligase (parkin)
HGNC ID: 8607
Synonyms: PDJ, AR-JP, parkin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APOBEC3G | 1 hits |
| 2 | BST2 | 1 hits |
| 3 | CD8A | 1 hits |
| 4 | CUL1 | 1 hits |
| 5 | CUL5 | 1 hits |
| 6 | FBXW10 | 1 hits |
| 7 | IFNGR1 | 1 hits |
| 8 | KITLG | 1 hits |
| 9 | RB1 | 1 hits |
| 10 | TP53 | 1 hits |
| 11 | TRIB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19177752 | The E6 and E7 genes of HPVs are thought to play causative roles, since E6 promotes the degradation of p53 through its interaction with E6AP, an E3 ubiquitin ligase, whereas E7 binds to the retinoblastoma protein pRb and disrupts its complex formation with E2F transcription factors. |
| 2 | 21383769 | Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine. |
| 3 | 21383769 | The E3 ubiquitin ligase Cbl-b is a key regulator of T cell activation and is established to regulate TGF-β sensitivity. cblb-deficient animals reject tumors via CD8(+) T cells, which make Cbl-b an ideal target for improvement of adoptive T-cell transfer (ATC) therapy. |
| 4 | 21383769 | In this study, we show that cblb-deficient CD8(+) T cells are hyper-responsive to T-cell receptor (TCR)/CD28-stimulation and are in part protected against the negative cues induced by TGF-β in vitro. |
| 5 | 21383769 | Thus, cblb-deficient ATC requires proper in vivo re-activation by a dendritic cell (DC) vaccine. |
| 6 | 22379088 | Vif recruits cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein APOBEC3G (A3G) for proteasomal degradation. |
| 7 | 22383521 | The HIV-1 accessory protein Vpu binds to both BST-2 and βTrCP, a substrate-recognition subunit for the SCF (Skip1-Cullin1-F-box protein) E3 ubiquitin ligase complex. |