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Gene Information
Gene symbol: PDIA6
Gene name: protein disulfide isomerase family A, member 6
HGNC ID: 30168
Synonyms: P5, ERp5
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CSF2 | 1 hits |
| 2 | CTLA4 | 1 hits |
| 3 | HLA-A | 1 hits |
| 4 | KLRK1 | 1 hits |
| 5 | MICA | 1 hits |
| 6 | P4HB | 1 hits |
| 7 | TXNDC15 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18202175 | Here, we demonstrate that NKG2D, an activating receptor on natural killer (NK) cells, CD8(+) T lymphocytes, and MHC class I chain-related protein A (MICA), an NKG2D ligand induced in malignant plasma cells through DNA damage, contribute to the pathogenesis of MGUS and MM. |
| 2 | 18202175 | MICA expression is increased on plasma cells from MGUS patients compared with normal donors, whereas MM patients display intermediate MICA levels and a high expression of ERp5, a protein disulfide isomerase linked to MICA shedding (sMICA). |
| 3 | 19008459 | Toward this end, we screened a murine renal cell carcinoma cDNA expression library with sera from mice vaccinated with irradiated tumor cells engineered to secrete granulocyte macrophage colony-stimulating factor (GM-CSF). |
| 4 | 19008459 | High titer antibodies to human PDI were similarly induced in an acute myeloid leukemia patient who achieved a complete response after vaccination with irradiated, autologous GM-CSF-secreting tumor cells in the setting of nonmyeloablative allogeneic bone marrow transplantation. |
| 5 | 19008459 | Moreover, ERp5, a closely related disulfide isomerase involved in major histocompatibility complex (MHC) class I chain-related protein A (MICA) shedding, also evoked potent humoral reactions in diverse solid and hematologic malignancy patients who responded to GM-CSF-secreting tumor cell vaccines or antibody blockade of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). |
| 6 | 19769739 | Through this approach, we uncovered the immunogenicity of major histocompatibility chain-related protein A (MICA), which is a ligand for NKG2D, and ERp5, a protein disulfide isomerase involved in MICA shedding. |