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Gene Information
Gene symbol: PDIK1L
Gene name: PDLIM1 interacting kinase 1 like
HGNC ID: 18981
Synonyms: CLIK1L
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CSNK2A1 | 1 hits |
| 2 | CSNK2B | 1 hits |
| 3 | IRF3 | 1 hits |
| 4 | TBK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15280222 | Many of the amino acid replacements were associated with the emergence of novel (or alternative) myristylation and casein kinase II (CKII) phosphorylation sites. |
| 2 | 15377422 | Cloning and expression in Escherichia coli of a new gene of Schistosoma japonicum encoding casein kinase II beta subunit. |
| 3 | 25810395 | Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection. |
| 4 | 25810395 | In this study, we report that protein kinase CK2 serves as a key component controlling TBK1 and IRF3 activation in IFN-inducing TLR, RIG-I-like receptors, and cGAS/STING signaling pathways. |
| 5 | 25810395 | Moreover, PP2A was identified as one of the intermediate phosphatases responsible for CK2-regulated IFN response, suggesting that CK2 may regulate TBK1 and IRF3 activation indirectly. |
| 6 | 25810395 | Taken together, our results identify CK2 as a novel regulator of TBK1 and IRF3 and suggest that targeting CK2 by small molecular inhibitor may be a viable approach to prevent and treat viral infections. |