Ignet

Gene Information

Gene symbol: PIAS1

Gene name: protein inhibitor of activated STAT, 1

HGNC ID: 2752

Synonyms: GBP, GU/RH-II, ZMIZ3

Related Genes

#	Gene Symbol	Number of hits
1	CD4	1 hits
2	GATA3	1 hits
3	IL13	1 hits
4	IL15	1 hits
5	IL4	1 hits
6	IL5	1 hits
7	STAT3	1 hits

Related Sentences

#	PMID	Sentence
1	18056374	Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.
2	18056374	Here, we reported a number of GATA-3 associated proteins in Th2 cells, and one of such proteins Pias1 functioned as a positive transcriptional coregulator for GATA-3.
3	18056374	When overexpressed in Th2 cells, Pias1 enhanced the expression of IL-13, and to lesser degrees, IL-4 and -5.
4	18056374	In Leishmania major infection, manipulating Pias1 expression in parasite-reactive CD4 T cells altered severity of disease caused by Th2 responses.
5	18056374	Mechanistically, Pias1 markedly potentiated GATA-3-mediated activation of the IL-13 promoter by facilitating the recruitment of GATA-3 to the promoter.
6	18056374	In contrast, IL-5 promoter was modestly enhanced by Pias1 and no effect was observed on IL-4 promoter.
7	18056374	Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.
8	18056374	Here, we reported a number of GATA-3 associated proteins in Th2 cells, and one of such proteins Pias1 functioned as a positive transcriptional coregulator for GATA-3.
9	18056374	When overexpressed in Th2 cells, Pias1 enhanced the expression of IL-13, and to lesser degrees, IL-4 and -5.
10	18056374	In Leishmania major infection, manipulating Pias1 expression in parasite-reactive CD4 T cells altered severity of disease caused by Th2 responses.
11	18056374	Mechanistically, Pias1 markedly potentiated GATA-3-mediated activation of the IL-13 promoter by facilitating the recruitment of GATA-3 to the promoter.
12	18056374	In contrast, IL-5 promoter was modestly enhanced by Pias1 and no effect was observed on IL-4 promoter.
13	18056374	Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.
14	18056374	Here, we reported a number of GATA-3 associated proteins in Th2 cells, and one of such proteins Pias1 functioned as a positive transcriptional coregulator for GATA-3.
15	18056374	When overexpressed in Th2 cells, Pias1 enhanced the expression of IL-13, and to lesser degrees, IL-4 and -5.
16	18056374	In Leishmania major infection, manipulating Pias1 expression in parasite-reactive CD4 T cells altered severity of disease caused by Th2 responses.
17	18056374	Mechanistically, Pias1 markedly potentiated GATA-3-mediated activation of the IL-13 promoter by facilitating the recruitment of GATA-3 to the promoter.
18	18056374	In contrast, IL-5 promoter was modestly enhanced by Pias1 and no effect was observed on IL-4 promoter.
19	18056374	Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.
20	18056374	Here, we reported a number of GATA-3 associated proteins in Th2 cells, and one of such proteins Pias1 functioned as a positive transcriptional coregulator for GATA-3.
21	18056374	When overexpressed in Th2 cells, Pias1 enhanced the expression of IL-13, and to lesser degrees, IL-4 and -5.
22	18056374	In Leishmania major infection, manipulating Pias1 expression in parasite-reactive CD4 T cells altered severity of disease caused by Th2 responses.
23	18056374	Mechanistically, Pias1 markedly potentiated GATA-3-mediated activation of the IL-13 promoter by facilitating the recruitment of GATA-3 to the promoter.
24	18056374	In contrast, IL-5 promoter was modestly enhanced by Pias1 and no effect was observed on IL-4 promoter.
25	18056374	Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.
26	18056374	Here, we reported a number of GATA-3 associated proteins in Th2 cells, and one of such proteins Pias1 functioned as a positive transcriptional coregulator for GATA-3.
27	18056374	When overexpressed in Th2 cells, Pias1 enhanced the expression of IL-13, and to lesser degrees, IL-4 and -5.
28	18056374	In Leishmania major infection, manipulating Pias1 expression in parasite-reactive CD4 T cells altered severity of disease caused by Th2 responses.
29	18056374	Mechanistically, Pias1 markedly potentiated GATA-3-mediated activation of the IL-13 promoter by facilitating the recruitment of GATA-3 to the promoter.
30	18056374	In contrast, IL-5 promoter was modestly enhanced by Pias1 and no effect was observed on IL-4 promoter.
31	18056374	Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.
32	18056374	Here, we reported a number of GATA-3 associated proteins in Th2 cells, and one of such proteins Pias1 functioned as a positive transcriptional coregulator for GATA-3.
33	18056374	When overexpressed in Th2 cells, Pias1 enhanced the expression of IL-13, and to lesser degrees, IL-4 and -5.
34	18056374	In Leishmania major infection, manipulating Pias1 expression in parasite-reactive CD4 T cells altered severity of disease caused by Th2 responses.
35	18056374	Mechanistically, Pias1 markedly potentiated GATA-3-mediated activation of the IL-13 promoter by facilitating the recruitment of GATA-3 to the promoter.
36	18056374	In contrast, IL-5 promoter was modestly enhanced by Pias1 and no effect was observed on IL-4 promoter.
37	24777831	PIAS1 and STAT-3 impair the tumoricidal potential of IFN-γ-stimulated mouse dendritic cells generated with IL-15.
38	24777831	We report here that the tumoricidal potential of mouse DCs generated from myeloid precursors with GM-CSF and IL-15 (IL-15 DCs) can be triggered with the Toll-like receptor (TLR) 4 ligand lipopolysaccharide to a similar extent compared with that of their counterparts, conventionally generated with IL-4 (IL-4 DCs).
39	24777831	In contrast, interferon (IFN)-γ induces the cytotoxic activity of IL-4 but not IL-15 DCs.
40	24777831	Although the IFN-γ-STAT-1 signaling pathway is overall functional in IL-15 DCs, IFN-γ fails to induce iNOS expression in these cells. iNOS expression is negatively controlled in IFN-γ-stimulated IL-15 DCs by the cooperation between the E3 SUMO ligase PIAS1 and STAT-3, and can be partially restored with PIAS1 siRNA and STAT-3 inhibitors.
41	24777831	PIAS1 and STAT-3 impair the tumoricidal potential of IFN-γ-stimulated mouse dendritic cells generated with IL-15.
42	24777831	We report here that the tumoricidal potential of mouse DCs generated from myeloid precursors with GM-CSF and IL-15 (IL-15 DCs) can be triggered with the Toll-like receptor (TLR) 4 ligand lipopolysaccharide to a similar extent compared with that of their counterparts, conventionally generated with IL-4 (IL-4 DCs).
43	24777831	In contrast, interferon (IFN)-γ induces the cytotoxic activity of IL-4 but not IL-15 DCs.
44	24777831	Although the IFN-γ-STAT-1 signaling pathway is overall functional in IL-15 DCs, IFN-γ fails to induce iNOS expression in these cells. iNOS expression is negatively controlled in IFN-γ-stimulated IL-15 DCs by the cooperation between the E3 SUMO ligase PIAS1 and STAT-3, and can be partially restored with PIAS1 siRNA and STAT-3 inhibitors.