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Gene Information
Gene symbol: PICALM
Gene name: phosphatidylinositol binding clathrin assembly protein
HGNC ID: 15514
Synonyms: CALM, CLTH
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
25748120
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Thus missense, splice site or duplication mutants in the presenilin 1 (PS1), presenilin 2 (PS2) or the amyloid precursor protein (APP) genes, which alter the levels or shift the balance of Aβ produced, are associated with rare, highly penetrant autosomal dominant forms of Familial Alzheimer's Disease (FAD).
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2 |
25748120
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Similarly, the more prevalent late-onset forms of AD are associated with both coding and non-coding variants in genes such as SORL1, PICALM and ABCA7 that affect the production and clearance of Aβ.
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