Ignet

Gene Information

Gene symbol: PIK3R3

Gene name: phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

HGNC ID: 8981

Synonyms: p55

Related Genes

#	Gene Symbol	Number of hits
1	C2orf28	1 hits
2	CD1A	1 hits
3	CD4	1 hits
4	CD80	1 hits
5	CD83	1 hits
6	CD86	1 hits
7	DCTN5	1 hits
8	ENPEP	1 hits
9	IL2	1 hits
10	IL2RA	1 hits
11	NRSN1	1 hits
12	PSIP1	1 hits
13	PSMD9	1 hits
14	S100A1	1 hits
15	TNF	1 hits
16	WDR48	1 hits

Related Sentences

#	PMID	Sentence
1	1988163	Recombinant diphtheria toxin-related interleukin-2 fusion protein (DAB486IL-2) is specifically cytotoxic for cells bearing the high-affinity IL-2 receptor (p55/75).
2	1988163	The induction of the p55 (Tac) subunit of the IL-2R was demonstrable by two-color flow cytometry on a small percentage (5%) of B cells and on a higher percentage (10%) of non-B cells 3 days after exposure to TT-coupled Sepharose.
3	1988163	Recombinant diphtheria toxin-related interleukin-2 fusion protein (DAB486IL-2) is specifically cytotoxic for cells bearing the high-affinity IL-2 receptor (p55/75).
4	1988163	The induction of the p55 (Tac) subunit of the IL-2R was demonstrable by two-color flow cytometry on a small percentage (5%) of B cells and on a higher percentage (10%) of non-B cells 3 days after exposure to TT-coupled Sepharose.
5	3131768	Targeting the low-affinity IL-2-binding p55 subunit of the high-affinity IL-2R with the rat anti-mouse IgM monoclonal antibody M7/20 suppresses a variety of T-cell-mediated reactions, including transplant rejection, autoimmunity, and delayed-type hypersensitivity (DTH).
6	3131768	A hybrid IL-2-toxin gene was constructed from the diphtheria toxin gene by replacing the DNA encoding the diphtheria toxin receptor-binding domain with the DNA encoding the receptor-binding domain of IL-2, and the fusion protein encoded by the hybrid gene was expressed in Escherichia coli [Williams, D.P., Parker, K., Bacha, P., Bishai, W., Borowski, M., Genbauffe, F., Strom, T.B.
7	3131768	Treatment of mice with the IL-2-toxin blocks DTH and prevents expansion of IL-2R+ T cells.
8	3131768	Indeed, IL-2-toxin treatment targets IL-2R+ T cells in vivo and is shown to selectively eliminate their appearance in draining lymph nodes.
9	7580832	Immunization with gp160 in saline induced the formation of antibodies directed to the p18 protein, whereas the gp160 adsorbed onto calcium phosphate elicited antibodies recognizing the gp160, p55, p25 and p18 proteins.
10	7919109	Sera of rabbits immunized with the adjuvanted preparation contained high levels of anti-gp160 antibodies, as well as antibodies recognizing p55, p25 and p18.
11	8376800	The airway T cells persist at elevated levels at least up to 10 wk and will secrete IFN-gamma and IL-3 upon antigenic stimulation in vitro.
12	8376800	We report here that more CD4+ T cells from the airways responded rapidly to mitogen by up-regulating the p55 subunit of the IL-2R than did splenocytes from the same animal, suggesting that the bulk of the pulmonary Th infiltrate comprised previously activated cells.
13	8376800	Virtually all of the pulmonary CD4+ T cells expressed high levels of the memory marker CD44 (Pgp-1), in contrast with the situation in the draining LN and circulation where only a minority were in that category.
14	8743085	To evaluate the predictive power of EpiMer, the amino acid sequences of the HIV-1 proteins nef, gp160, gag p55, and tat were searched for regions of MHC-binding motif clustering.
15	8993754	These include the ability to augment and accelerate reactions of delayed hypersensitivity against antigens to which the test subject has been previously sensitized, and the ability to enhance the expression in vitro on CD4 lymphocytes of the p55 subunit of the receptor for Interleukin-2.
16	8993754	We also report our observation that in a patient with advanced HIV disease whose lymphocytes had lost there ability to properly express the IL-2 receptor, treatment with IMREGR-1 over a period of months restored the expression of the IL-2 receptor on the patient's CD4+ lymphocytes towards normal.
17	9310466	Proliferating human bone marrow and cord blood CD34+ cells were infected by retroviral vectors encoding the murine CD2 surface antigen.
18	9310466	Transduced or untransduced dendritic cell progeny expressed comparable levels of HLA-DR, CD83, CD1a, CD80, CD86, S100, and p55 antigens.
19	9421852	However, postoperative increase of soluble TNF-receptors p55 and p75 was also significant in patients transfused with allogenic blood (p = .022; p = .0014).
20	11595294	In this study, the proliferative responses to HIV p24, p55 and gp120 were evaluated in infected subjects.
21	16929598	The sera from HIVREPOL-vaccinated mice recognized the proteins gp41, p24, p55 of cultured HIV1 on "New-Lay-Blot1" strips.
22	17287317	The assay is based on two M. agalactiae surface proteins, namely, P80 and P55.
23	24588000	When tested in cattle, MbΔp27-p55 did not induce IL-2 expression and induced a very low production of IFNγ, suggesting that the lack of P27/P55 reduces the capacity of M. bovis of triggering an adequate Th1 response.