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Gene Information
Gene symbol: PLA2G4A
Gene name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
HGNC ID: 9035
Synonyms: cPLA2-alpha
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | JAK3 | 1 hits |
| 2 | PLA2G1B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24343645 | Janus kinase 3 activity is necessary for phosphorylation of cytosolic phospholipase A2 and prostaglandin E2 synthesis by macrophages infected with Francisella tularensis live vaccine strain. |
| 2 | 24343645 | The synthesis of PGE2 begins with the liberation of arachidonic acid (AA) from membrane phospholipids by cytosolic phospholipase A2 (cPLA2). |
| 3 | 24343645 | In this study, we show that cPLA2, p38 mitogen-activated protein kinase (MAPK), and Janus kinase 3 (JAK3) signaling are necessary for F. tularensis-induced PGE2 production. |
| 4 | 24343645 | Inhibition of JAK3 activity reduced the phosphorylation of cPLA2 and COX-2 protein levels. |
| 5 | 24343645 | In addition, JAK3 regulates cPLA2 phosphorylation independent of transcription. |
| 6 | 24343645 | Moreover, p38 MAPK activity is required for F. tularensis-induced COX-2 protein synthesis, but not for the phosphorylation of cPLA2. |
| 7 | 24343645 | This research highlights a unique signaling axis in which JAK3 and p38 MAPK regulate the activity of multiple enzymes of the PGE2-biosynthetic pathway in macrophages infected with F. tularensis. |
| 8 | 24343645 | Janus kinase 3 activity is necessary for phosphorylation of cytosolic phospholipase A2 and prostaglandin E2 synthesis by macrophages infected with Francisella tularensis live vaccine strain. |
| 9 | 24343645 | The synthesis of PGE2 begins with the liberation of arachidonic acid (AA) from membrane phospholipids by cytosolic phospholipase A2 (cPLA2). |
| 10 | 24343645 | In this study, we show that cPLA2, p38 mitogen-activated protein kinase (MAPK), and Janus kinase 3 (JAK3) signaling are necessary for F. tularensis-induced PGE2 production. |
| 11 | 24343645 | Inhibition of JAK3 activity reduced the phosphorylation of cPLA2 and COX-2 protein levels. |
| 12 | 24343645 | In addition, JAK3 regulates cPLA2 phosphorylation independent of transcription. |
| 13 | 24343645 | Moreover, p38 MAPK activity is required for F. tularensis-induced COX-2 protein synthesis, but not for the phosphorylation of cPLA2. |
| 14 | 24343645 | This research highlights a unique signaling axis in which JAK3 and p38 MAPK regulate the activity of multiple enzymes of the PGE2-biosynthetic pathway in macrophages infected with F. tularensis. |